Search Results - "Nimmrich, V."

Calcium channel blockers and dementia by Nimmrich, V, Eckert, A

“…Degenerative dementia is mainly caused by Alzheimer's disease and/or cerebrovascular abnormalities. Disturbance of the intracellular calcium homeostasis is…”
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P/Q‐type calcium channel modulators by Nimmrich, V, Gross, G

“…P/Q‐type calcium channels are high‐voltage‐gated calcium channels contributing to vesicle release at synaptic terminals. A number of neurological diseases have…”
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A monoclonal antibody against the receptor for advanced glycation end products attenuates inflammatory and neuropathic pain in the mouse by Brederson, J.-D., Strakhova, M., Mills, C., Barlow, E., Meyer, A., Nimmrich, V., Leddy, M., Simler, G., Schmidt, M., Jarvis, M., Lacy, S.

“…Background The receptor for advanced glycation end products (RAGE) is a multi‐ligand receptor in the immunoglobulin superfamily. RAGE is localized throughout…”
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A β‐amyloid oligomer directly modulates P/Q‐type calcium currents in Xenopus oocytes by Mezler, M, Barghorn, S, Schoemaker, H, Gross, G, Nimmrich, V

“…BACKGROUND AND PURPOSE β‐amyloid (Aβ) oligomers have been implicated in the early pathophysiology of Alzheimer's disease (AD). While the precise nature of the…”
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Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein–overexpressing mice without altering behaviorally-correlated sharp wave–ripple complexes by Hermann, D, Both, M, Ebert, U, Gross, G, Schoemaker, H, Draguhn, A, Wicke, K, Nimmrich, V

“…Abstract One of the hallmarks of Alzheimer's disease is the accumulation of amyloid plaques in brains of affected patients. Several recent studies provided…”
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Inhibition of calpain prevents NMDA‐induced cell death and β‐amyloid‐induced synaptic dysfunction in hippocampal slice cultures by Nimmrich, V, Reymann, KG, Strassburger, M, Schöder, UH, Gross, G, Hahn, A, Schoemaker, H, Wicke, K, Möller, A

“…Background and purpose:  Alzheimer's disease (AD) is a multifactorial, neurodegenerative disease, which is in part caused by an impairment of synaptic…”
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Non-invasive characterization of β-amyloid1-40 vasoactivity by functional magnetic resonance imaging in mice by Luo, F, Seifert, T.R, Edalji, R, Loebbert, R.W, Hradil, V.P, Harlan, J, Schmidt, M, Nimmrich, V, Cox, B.F, Fox, G.B

“…Abstract Neurovascular regulation, which is critical to the efficient functioning of the brain, is impaired in Alzheimer's disease and in transgenic mice…”
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Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis by Hofmann, I, Mertens, C, Brettel, M, Nimmrich, V, Schnölzer, M, Herrmann, H

“…Plakophilin 1 and 2 (PKP1, PKP2) are members of the arm-repeat protein family. They are both constitutively expressed in most vertebrate cells, in two splice…”
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Long-term maintenance of mature hippocampal slices in vitro by Xiang, Zhongmin, Hrabetova, Sabina, Moskowitz, Shaye I., Casaccia-Bonnefil, Patrizia, Young, Steven R., Nimmrich, Volker C., Tiedge, Henri, Einheber, Stephen, Karnup, Sergei, Bianchi, Riccardo, Bergold, Peter J.

“…Cultures of primary neurons or thin brain slices are typically prepared from immature animals. We introduce a method to prepare hippocampal slice cultures from…”
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Truncation mutagenesis of the non-alpha-helical carboxyterminal tail domain of vimentin reveals contributions to cellular localization but not to filament assembly by Rogers, K R, Eckelt, A, Nimmrich, V, Janssen, K P, Schliwa, M, Herrmann, H, Franke, W W

“…We have investigated the effect of stepwise truncating the carboxyterminal domain ("tail") of the intermediate filament (IF) protein vimentin of the clawed…”
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A [beta]-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes by Mezler, M, Barghorn, S, Schoemaker, H, Gross, G, Nimmrich, V

“…BACKGROUND AND PURPOSE [beta]-amyloid (A[beta]) oligomers have been implicated in the early pathophysiology of Alzheimer's disease (AD). While the precise…”
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Inhibition of calpain prevents NMDA-induced cell death and b-amyloid-induced synaptic dysfunction in hippocampal slice cultures by Nimmrich, V, Strassburger, M, Gross, G, Hahn, A, Schoemaker, H, Wicke, K, Moller, A

“…Background and purpose: Alzheimer's disease (AD) is a multifactorial, neurodegenerative disease, which is in part caused by an impairment of synaptic function,…”
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Inhibition of calpain prevents NMDA-induced cell death and [beta]-amyloid-induced synaptic dysfunction in hippocampal slice cultures by Nimmrich, V, Reymann, KG, Strassburger, M, Schoder, UH, Gross, G, Hahn, A, Schoemaker, H, Wicke, K, Moller, A

“…Background and purpose: Alzheimer's disease (AD) is a multifactorial, neurodegenerative disease, which is in part caused by an impairment of synaptic function,…”
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Non-invasive characterization of beta-amyloid(1-40) vasoactivity by functional magnetic resonance imaging in mice by Luo, F, Seifert, T R, Edalji, R, Loebbert, R W, Hradil, V P, Harlan, J, Schmidt, M, Nimmrich, V, Cox, B F, Fox, G B

“…Neurovascular regulation, which is critical to the efficient functioning of the brain, is impaired in Alzheimer's disease and in transgenic mice overexpressing…”
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Establishment of a secondary screening assay for P/Q-type calcium channel blockers by Hermann, David, Mezler, Mario, Swensen, Andrew M, Bruehl, Claus, Obergrußerger, Ali, Wicke, Karsten, Schoemaker, Hans, Gross, Gerhard, Draguhn, Andreas, Nimmrich, Volker

“…Development of calcium channel blockers is attractive, but has in the past been hampered by lack of high throughput electrophysiological technology. This…”
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Non-invasive characterization of β-amyloid 1-40 vasoactivity by functional magnetic resonance imaging in mice by Luo, F., Seifert, T.R., Edalji, R., Loebbert, R.W., Hradil, V.P., Harlan, J., Schmidt, M., Nimmrich, V., Cox, B.F., Fox, G.B.

“…Neurovascular regulation, which is critical to the efficient functioning of the brain, is impaired in Alzheimer's disease and in transgenic mice overexpressing…”
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Development and validation of a fluorescence-based HTS assay for the identification of P/Q-type calcium channel blockers by Mezler, Mario, Hermann, David, Swensen, Andrew M, Draguhn, Andreas, Terstappen, Georg C, Gross, Gerhard, Schoemaker, Hans, Freiberg, Gail, Pratt, Steve, Gopalakrishnan, Sujatha M, Nimmrich, Volker

“…Dysfunction of P/Q-type calcium channels is thought to underlie a variety of neurological diseases. There is evidence that migraine, Alzheimer's disease, and…”
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Non-invasive characterization of beta -amyloid sub(1) sub(-) sub(4) sub(0) vasoactivity by functional magnetic resonance imaging in mice by Luo, F, Seifert, T R, Edalji, R, Loebbert, R W, Hradil, V P, Harlan, J, Schmidt, M, Nimmrich, V, Cox, B F, Fox, G B

“…Neurovascular regulation, which is critical to the efficient functioning of the brain, is impaired in Alzheimer's disease and in transgenic mice overexpressing…”
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Dendritic BC1 RNA: modulation by kindling-induced afterdischarges by Nimmrich, Volker, Hargreaves, Eric L., Muslimov, Ilham A., Bianchi, Riccardo, Tiedge, Henri

“…Local protein synthesis in dendrites is thought to provide a mechanism for long-lasting modifications of synapses in response to physiological activity and…”
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