Search Results - "Nimmo, E."

MicroRNAs: new players in IBD by Kalla, R, Ventham, N T, Kennedy, N A, Quintana, J F, Nimmo, E R, Buck, A H, Satsangi, J

“…MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly…”
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ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach by Ho, G.-T., Soranzo, N., Nimmo, E.R., Tenesa, A., Goldstein, D.B., Satsangi, J.

“…Several lines of evidence suggest a role for the multidrug resistance gene (ABCB1/MDR1) and its product, P-glycoprotein 170, in the pathogenesis of…”
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A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis by Rivas, Manuel A., Graham, Daniel, Sulem, Patrick, Stevens, Christine, Desch, A. Nicole, Goyette, Philippe, Gudbjartsson, Daniel, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Degenhardt, Frauke, Mucha, Sören, Kurki, Mitja I., Li, Dalin, D’Amato, Mauro, Annese, Vito, Vermeire, Severine, Weersma, Rinse K., Halfvarson, Jonas, Paavola-Sakki, Paulina, Lappalainen, Maarit, Lek, Monkol, Cummings, Beryl, Tukiainen, Taru, Haritunians, Talin, Halme, Leena, Koskinen, Lotta L. E., Ananthakrishnan, Ashwin N., Luo, Yang, Heap, Graham A., Visschedijk, Marijn C., MacArthur, Daniel G., Neale, Benjamin M., Ahmad, Tariq, Anderson, Carl A., Brant, Steven R., Duerr, Richard H., Silverberg, Mark S., Cho, Judy H, Palotie, Aarno, Saavalainen, Päivi, Kontula, Kimmo, Färkkilä, Martti, McGovern, Dermot P. B., Franke, Andre, Stefansson, Kari, Rioux, John D., Xavier, Ramnik J., Daly, Mark J.

“…Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a…”
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NOD2 CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? by Arnott, I D R, Nimmo, E R, Drummond, H E, Fennell, J, Smith, B R K, MacKinlay, E, Morecroft, J, Anderson, N, Kelleher, D, O'Sullivan, M, McManus, R, Satsangi, J

“…NOD2/caspase recruitment domain (CARD)15 variants are identified in up to 50% of Crohn's disease (CD) patients. Functional variants of toll-like receptor-4…”
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DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population by Noble, C L, Nimmo, E R, Drummond, H, Smith, L, Arnott, I D R, Satsangi, J

“…Introduction: Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to…”
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Anti‐Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations by WALKER, L. J., ALDHOUS, M. C., DRUMMOND, H. E., SMITH, B. R. K., NIMMO, E. R., ARNOTT, I. D. R., SATSANGI, J.

“…SUMMARY Anti‐Saccharomyces cerevisiae antibodies (ASCAs) have been proposed as serological markers, which may differentiate Crohn's disease (CD) from…”
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Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease by Russell, R K, Drummond, H E, Nimmo, E R, Anderson, N H, Noble, C L, Wilson, D C, Gillett, P M, McGrogan, P, Hassan, K, Weaver, L T, Bisset, W M, Mahdi, G, Satsangi, J

“…Background and aims: The OCTN1 (SLC22A4 1672C→T) and OCTN2 (SLC22A5 −207G→C) variants within the IBD5 locus have been associated with susceptibility to adult…”
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Autophagy: from basic science to clinical application by Van Limbergen, J, Stevens, C, Nimmo, ER, Wilson, DC, Satsangi, J

“…Autophagy is a cellular pathway involved in protein and organelle degradation, which is likely to represent an innate adaptation to starvation. In times of…”
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Scientific Business Abstracts of the 112th Annual Meeting of the Association of Physicians of Great Britain and Ireland by Chauhan, A, Lalor, T, Watson, S, Adams, D, Farrah, T E, Anand, A, Kimmitt, R, Mills, N L, Webb, D J, Dhaun, N, Kalla, R, Adams, A, Vatn, S, Bonfliglio, F, Nimmo, E, Kennedy, N, Ventham, N, Vatn, M, Ricanek, P, Halfvarson, J, Soderhollm, J, Pierik, M, Torkvist, L, Gomollon, F, Gut, I, Jahnsen, J, Satsangi, J, Body, R, Almashali, M, McDowell, G, Taylor, P, Lacey, A, Rees, A, Ludgate, Dayan, C, Lazarus, J, Nelson, S, Okosieme, O, Corcoran, D, Young, R, Ciadella, P, McCartney, P, Bajrangee, A, Hennigan, B, Collison, D, Carrick, D, Shaukat, A, Good, R, Watkins, S, McEntegart, M, Watt, J, Welsh, P, Sattar, N, McConnachie, A, Oldroyd, K, Berry, C, Parks, T, Auckland, K, Mentzer, A J, Kado, J, Mirabel, M M, Kauwe, J K, Robson, K J, Mittal, B, Steer, A C, Hill, A V S, Akbar, M, Forrester, M, Virlan, A T, Gilmour, A, Wallace, C, Paterson, C, Reid, D, Siebert, S, Porter, D, Liversidge, J, McInnes, I, Goodyear, C, Athwal, V, Pritchett, J, Zaitoun, A, Irving, W, Guha, I N, Hanley, N A, Hanley, K P, Briggs, T, Reynolds, J, Rice, G, Bondet, V, Bruce, E, Crow, Y, Duffy, D, Parker, B, Bruce, I, Martin, K, Pritchett, J, Aoibheann Mullan, M, Llewellyn, J, Athwal, V, Zeef, L

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IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland by Van Limbergen, J, Russell, %R K, Nimmo, E R, Drummond, H E, Smith, L, Davies, G, Anderson, N H, Gillett, P M, McGrogan, P, Hassan, K, Weaver, L, Bisset, W M, Mahdi, G, Wilson, D C, Satsangi, J

“…The discovery of NOD2/CARD15 as the first susceptibility gene in Crohn's disease has contributed significantly to a fundamental change in the direction of…”
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Exploring the hidden heritability of inflammatory bowel disease by Satsangi, J, Kennedy, N A, Henderson, P, Wilson, D C, Nimmo, E R

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Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation by Allshire, R C, Nimmo, E R, Ekwall, K, Javerzat, J P, Cranston, G

“…The ura4+ gene displays phenotypes consistent with variegated expression when inserted at 11 sites throughout fission yeast centromere 1. An abrupt transition…”
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Regulation of telomere length and function by a Myb-domain protein in fission yeast by Cooper, J.P, Nimmo, E.R, Allshire, R.C, Cech, T.R

“…Telomeres, the specialized nucleoprotein structures that comprise the ends of eukaryotic chromosomes, are essential for complete replication, and regulation of…”
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Haplotype-tagging analysis of common variants of the IL23R gene demonstrates gene-wide extent of association with IBD by Van Limbergen, Johan, Russell, Richard K, Nimmo, E R, Kabakchiev, Boyko, Drummond, H E, Satsangi, Jack, Wilson, David C

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Epigenetic alterations at diagnosis predict susceptibility, prognosis and treatment escalation in inflammatory bowel disease - IBD Character by Adams, A., Kalla, R., Vatn, S., Bonfiglio, F., Nimmo, E., Kennedy, N., Ventham, N., Vatn, M., Ricanek, P., Bergemalm, Daniel, Halfvarson, Jonas, Söderholm, J., Pierik, M., Törkvist, L., Gomollon, F., Gut, I., Jahnsen, J., Satsangi, J.

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Low body mass not vitamin D receptor polymorphisms predict osteoporosis in patients with inflammatory bowel disease by NOBLE, C. L., MCCULLOUGH, J., HO, W., LEES, C. W., NIMMO, E., DRUMMOND, H., BEAR, S., HANNAN, J., MILLAR, C., RALSTON, S. H., SATSANGI, J.

“…Summary Background  Osteoporosis is a recognized complication of inflammatory bowel disease (IBD). Aim  To investigate the role of environmental factors and…”
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Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function by Ekwall, K, Nimmo, E R, Javerzat, J P, Borgstrøm, B, Egel, R, Cranston, G, Allshire, R

“…Transcriptional silencing is known to occur at centromeres, telomeres and the mating type region in the nucleus of fission yeast, Schizosaccharomyces pombe…”
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Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood‐onset in Crohn's disease in Northern Europe by Van Limbergen, J., Russell, R.K., Nimmo, E.R., Drummond, H.E., Smith, L., Anderson, N.H., Davies, G., Gillett, P.M., McGrogan, P., Weaver, L.T., Bisset, W.M., Mahdi, G., Arnott, I.D., Wilson, D.C., Satsangi, J.

“…Background: The rs2241880A/G variant of the ATG16L1 gene has been associated with susceptibility to ileal Crohn's disease (CD) in adults. Our aim was to assess…”
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Contribution of the NOD1/CARD4 insertion/deletion polymorphism +32656 to inflammatory bowel disease in Northern Europe by Van Limbergen, J., Russell, R.K., Nimmo, E.R., Törkvist, L., Lees, C.W., Drummond, H.E., Smith, L., Anderson, N.H., Gillett, P.M., McGrogan, P., Hassan, K., Weaver, L.T., Bisset, W.M., Mahdi, G., Arnott, I.D., Sjöqvist, U., Lördal, M., Farrington, S.M., Dunlop, M.G., Wilson, D.C., Satsangi, J.

“…Background: NOD1/CARD4 and NOD2/CARD15 are both intracellular pattern‐recognition receptors. The NOD1/CARD4 gene lies within a previously described…”
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Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts by Browning, B L, Annese, V, Barclay, M L, Bingham, S A, Brand, S, Büning, C, Castro, M, Cucchiara, S, Dallapiccola, B, Drummond, H, Ferguson, L R, Ferraris, A, Fisher, S A, Gearry, R B, Glas, J, Henckaerts, L, Huebner, C, Knafelz, D, Lakatos, L, Lakatos, P L, Latiano, A, Liu, X, Mathew, C, Müller-Myhsok, B, Newman, W G, Nimmo, E R, Noble, C L, Palmieri, O, Parkes, M, Petermann, I, Rutgeerts, P, Satsangi, J, Shelling, A N, Siminovitch, K A, Török, H-P, Tremelling, M, Vermeire, S, Valvano, M R, Witt, H

“…DLG5 p.R30Q has been reported to be associated with Crohn disease (CD), but this association has not been replicated in most studies. A recent analysis of…”
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