Search Results - "Nimjee, Shahid M."

Aptamers as Therapeutics by Nimjee, Shahid M, White, Rebekah R, Becker, Richard C, Sullenger, Bruce A

“…Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by…”
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Ischemic stroke in COVID-19-positive patients: an overview of SARS-CoV-2 and thrombotic mechanisms for the neurointerventionalist by Zakeri, Amanda, Jadhav, Ashutosh P, Sullenger, Bruce A, Nimjee, Shahid M

“…Coronavirus disease 2019 (COVID-19) results from infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first reported in Wuhan,…”
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Sex differences in thrombosis as it affects acute ischemic stroke by Nimjee, Shahid M., Akhter, Asad S., Zakeri, Amanda, Herson, Paco S.

“…Ischemic stroke is a devastating health problem, affecting approximately 800,000 patients in the US every year, making it the leading cause of combined death…”
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Beyond the Brain: The Systemic Pathophysiological Response to Acute Ischemic Stroke by Balch, Maria H.H., Nimjee, Shahid M., Rink, Cameron, Hannawi, Yousef

“…Stroke research has traditionally focused on the cerebral processes following ischemic brain injury, where oxygen and glucose deprivation incite prolonged…”
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Aptamers: an emerging class of therapeutics by Nimjee, Shahid M, Rusconi, Christopher P, Sullenger, Bruce A

“…Numerous nucleic acid ligands, also termed decoys or aptamers, have been developed during the past 15 years that can inhibit the activity of many pathogenic…”
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Harnessing cortical plasticity via gabapentinoid administration promotes recovery after stroke by Tedeschi, Andrea, Larson, Molly J E, Zouridakis, Antonia, Mo, Lujia, Bordbar, Arman, Myers, Julia M, Qin, Hannah Y, Rodocker, Haven I, Fan, Fan, Lannutti, John J, McElroy, Craig A, Nimjee, Shahid M, Peng, Juan, Arnold, W David, Moon, Lawrence D F, Sun, Wenjing

“…Stroke causes devastating sensory-motor deficits and long-term disability due to disruption of descending motor pathways. Restoration of these functions…”
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Pipeline embolization device for recurrence of previously treated aneurysms by Dornbos, 3rd, David, Karras, Constantine L, Wenger, Nicole, Priddy, Blake, Youssef, Patrick, Nimjee, Shahid M, Powers, Ciarán J

“…OBJECTIVE The utilization of the Pipeline embolization device (PED) has increased significantly since its inception and original approval for use in large,…”
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Von Willebrand factor targeted thrombolysis in canine basilar artery occlusion by Carfora, Arianna, Holthaus, Blake, Yacoub, Simon, Franceschelli, Dominic, Joseph, Matthew, Milks, Michael W, Mandybur, Ian, Anderson, Cole, Lee, Catherine, Huttinger, Allyson, Shujaat, Mohammad, Wheeler, Debra G, Sullenger, Bruce, Nimjee, Shahid M

“…Posterior circulation strokes, accounting for 20% of acute ischemic strokes, significantly contribute to morbidity and mortality. Fibrinolysis by rtPA improves…”
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Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion by Shea, Susan M, Thomas, Kimberly A, Rassam, Rassam M G, Mihalko, Emily P, Daniel, Christina, Sullenger, Bruce A, Spinella, Philip C, Nimjee, Shahid M

“…Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted…”
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Reversal of Systemic Anticoagulants and Antiplatelet Therapeutics by Dornbos, David, MD, Nimjee, Shahid M., MD, PhD

“…Although antiplatelet medications and anticoagulants are necessary for numerous cardiac comorbidities, prevention of stroke, and treatment and prevention of…”
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A Novel Case of Transverse Sinus Stenting and Ticagrelor Use During Pregnancy for Idiopathic Intracranial Hypertension by Patel, Mayur S., Akhter, Asad S., Rocco, Matthew T., Akhter, Abdussamad, Nimjee, Shahid M.

“…Background Idiopathic intracranial hypertension (IIH) is prevalent among the US population, with exacerbation of symptoms during pregnancy. Transverse sinus…”
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Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes by Gray, Bethany Powell, Kelly, Linsley, Steen-Burrell, Kady-Ann, Layzer, Juliana M., Rempel, Rachel E., Nimjee, Shahid M., Cooley, Brian C., Tarantal, Alice F., Sullenger, Bruce A.

“…Pathological blood clotting, or thrombosis, limits vital blood flow to organs; such deprivation can lead to catastrophic events including myocardial…”
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Review: Preclinical Models of Large‐Vessel Occlusion Stroke by Keister, Alexander, Carfora, Arianna, Patel, Mayur S., Zakeri, Amanda S., Mannix, Lillian, Wheeler, Debra G., Herson, Paco S., Nimjee, Shahid M.

“…Preclinical models of large‐vessel occlusion (LVO) stroke play an important role in testing novel thrombolytic and neuroprotective agents, as well as assessing…”
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Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli by Brinjikji, Waleed, Madalina Mereuta, Oana, Dai, Daying, Kallmes, David F, Savastano, Luis, Liu, Yang, Nimjee, Shahid M, Nogueira, Raul G, Abbasi, Mehdi, Kadirvel, Ramanathan

“…There has been growing interest and insight into the histological composition of retrieved stroke emboli. One of the main focuses of the stroke clot analysis…”
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Long-term Economic Impact of Coiling vs Clipping for Unruptured Intracranial Aneurysms by Lad, Shivanand P., Babu, Ranjith, Rhee, Michael S., Franklin, Robbi L., Ugiliweneza, Beatrice, Hodes, Jonathan, Nimjee, Shahid M., Zomorodi, Ali R., Smith, Tony P., Friedman, Allan H., Patil, Chirag G., Boakye, Maxwell

“…Abstract BACKGROUND: Treatment of unruptured intracranial aneurysms (UIAs) involves endovascular coiling or aneurysm clipping. While many studies have compared…”
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Coagulation and Hematology in Neurologic Surgery by Nimjee, Shahid M., MD, PhD, Lonser, Russell R., MD

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Use of Antiplatelet Agents in the Neurosurgical Patient by Zakeri, Amanda S., MD, Nimjee, Shahid M., MD, PhD

“…Antiplatelet agents used to treat neurovascular disease include aspirin; P2Y12 receptor antagonists clopidogrel, prasugrel, and ticagrelor; ADP antagonist…”
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Fibrinolysis without intracranial hemorrhage by Nimjee, Shahid M

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Antidote-mediated control of an anticoagulant aptamer in vivo by Rusconi, Christopher P, Sullenger, Bruce A, Roberts, Joseph D, Pitoc, George A, Nimjee, Shahid M, White, Rebekah R, Quick, George, Scardino, Elizabeth, Fay, William P

“…Patient safety and treatment outcome could be improved if physicians could rapidly control the activity of therapeutic agents in their patients. Antidote…”
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Intravenous Drug Use‐Associated Endocarditis Leads to Increased Intracranial Hemorrhage and Neurological Comorbidities by Hoang, Alex N., Shah, Varun, Granger, Jessica, III, David Dornbos, Youssef, Patrick P., Powers, Ciaran J., Tanweer, Omar, McCullough, Louise D., Nimjee, Shahid M.

“…Background The United States is experiencing a rapidly increasing rate of opioid drug abuse. Intravenous drug use (IVDU)‐related endocarditis can lead to…”
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