Search Results - "Nimjee, S M"

Antidote control of aptamer therapeutics: the road to a safer class of drug agents by Bompiani, K M, Woodruff, R S, Becker, R C, Nimjee, S M, Sullenger, B A

“…Aptamers, or nucleic acid ligands, have gained clinical interest over the past 20 years due to their unique characteristics, which are a combination of the…”
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Thrombectomy with Conscious Sedation Compared with General Anesthesia: A DEFUSE 3 Analysis by Powers, C J, Dornbos, 3rd, D, Mlynash, M, Gulati, D, Torbey, M, Nimjee, S M, Lansberg, M G, Albers, G W, Marks, M P

“…The optimal patient sedation during mechanical thrombectomy for ischemic stroke in the extended time window is unknown. The purpose of this study was to assess…”
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Targeted inhibition of alpha v beta 3 integrin with an RNA aptamer impairs endothelial cell growth and survival by Mi, J, Zhang, X, Giangrande, PH, McNamara, JO, Nimjee, S M, Sarraf-Yazdi, S, Sullenger, BA, Clary, B M

“…alpha v beta 3 integrin is a crucial factor involved in a variety of physiological processes, such as cell growth and migration, tumor invasion and metastasis,…”
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Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers by Oney, S, Nimjee, S M, Layzer, J, Que-Gewirth, N, Ginsburg, D, Becker, R C, Arepally, G, Sullenger, B A

“…Thrombus formation is initiated by platelets and leads to cardiovascular, cerebrovascular, and peripheral vascular disease, the leading causes of morbidity and…”
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Abstract 011: Early multi‐center experience with the NEVA VS in the treatment of subarachnoid hemorrhage‐related cerebral vasospasm by Schirmer, C M, Nimjee, S M, Savageau, E, Chen, M, Matouk, C, Koo, A, Hassan, A

“…IntroductionCerebral vasospasm represents a formidable challenge in the aftermath of subarachnoid hemorrhage (SAH), significantly contributing to morbidity and…”
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Indications for admission to the surgical intensive care unit after radical cystectomy and urinary diversion by Dahm, P, Tuttle-Newhall, J E, Nimjee, S M, Byrne, R R, Yowell, C W, Price, D T

“…We analyzed the practice of mandatory surgical intensive care unit admission after radical cystectomy, and defined objective criteria to predict active…”
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Abstract 001: Aspiration with super‐large bore 0.088 ID catheters in patients with acute ischemic stroke: The final results of an FDA‐approved trial by Mokin, M, Grossberg, J A, Tomalty, D, Majidi, S, Vargas, J, Cucchiara, B L, Snyder, K V, Mascitelli, J R, Parada, V, Shakir, H J, Rosenbaum-Halevi, D, Aghaebrahim, N, Hoit, D, Yim, B, Tenser, M S, Al-Bayati, A R, Milburn, J M, Singer, J A, Nimjee, S M, Haranhalli, N, Sheth, S A, Shaff, D I, Layton, K F, Beaty, N B, Starke, R M, Hawk, H, Haussen, D C, Pabaney, A, Kellner, C P, De Leacy, R A, Nogueira, R G, Mack, W J

“…IntroductionAspiration thrombectomy is a well‐established treatment for patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However,…”
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Aptamers: an emerging class of therapeutics by Nimjee, Shahid M, Rusconi, Christopher P, Sullenger, Bruce A

“…Numerous nucleic acid ligands, also termed decoys or aptamers, have been developed during the past 15 years that can inhibit the activity of many pathogenic…”
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RNA aptamer therapy for vaso-occlusion in sickle cell disease by Burnette, Angela D, Nimjee, Shahid M, Batchvarova, Milena, Zennadi, Rahima, Telen, Marilyn J, Nishimura, Jun-Ichi, Sullenger, Bruce A

“…Patients with sickle cell disease (SCD) often suffer painful vaso-occlusive episodes caused in part by the adhesion of sickle erythrocytes (SS-RBC) to the…”
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Antidote-mediated control of an anticoagulant aptamer in vivo by Rusconi, Christopher P, Sullenger, Bruce A, Roberts, Joseph D, Pitoc, George A, Nimjee, Shahid M, White, Rebekah R, Quick, George, Scardino, Elizabeth, Fay, William P

“…Patient safety and treatment outcome could be improved if physicians could rapidly control the activity of therapeutic agents in their patients. Antidote…”
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Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage by McGirt, Matthew J, Blessing, Robert, Nimjee, Shahid M, Friedman, Allan H, Alexander, Michael J, Laskowitz, Daniel T, Lynch, John R

“…Serum brain natriuretic peptide (BNP) is elevated after subarachnoid hemorrhage (SAH), causes diuresis and natriuresis (cerebral salt wasting), and may…”
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Correlation of cerebrospinal fluid flow dynamics and headache in Chiari I malformation by MCGIRT, Matthew J, NIMJEE, Shahid M, FLOYD, James, BULSARA, Ketan R, GEORGE, Timothy M, MENEZES, Arnold H, MCCOMB, J. Gordon, CHAPMAN, Paul H, MILHORAT, Thomas H

“…The management of patients with a Chiari I malformation who present with headaches alone remains unclear. We studied the cerebrospinal fluid (CSF) flow…”
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History of bipolar coagulation by Bulsara, Ketan R, Sukhla, Sunny, Nimjee, Shahid M

“…Bipolar coagulation heralded an age of improved hemostasis for microneurosurgery. This, coupled with an improved understanding of microsurgical anatomy, has…”
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Long-term follow-up in children with functional hemispherectomy for Rasmussen's encephalitis by Tubbs, R Shane, Nimjee, Shahid M, Oakes, W Jerry

“…Cerebral hemispherectomy has been performed for over 60 years. Multiple variations of functional hemispherectomy have been performed since its inception by…”
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Aptamers in the clinic by Nimjee, S.M., Sullenger, B.A.

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The Sabiston Vision of Basic Science in a Department of Surgery by Nimjee, Shahid M, Sullenger, Bruce A

“…“There are in fact two things, science and opinion; the former begets knowledge, the latter ignorance.”—Hippocrates (460 BC-377 BC)…”
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Comparison of total versus partial revision of initial ventriculoperitoneal shunt failures by McGirt, Matthew J, Wellons, 3rd, John C, Nimjee, Shahid M, Bulsara, Ketan R, Fuchs, Herbert E, George, Timothy M

“…Optimal surgical management of patients presenting with shunt failure in the age of neuroendoscopy remains complex. The value of replacing the entire shunt…”
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