Search Results - "Nimer, Stephen D."

Myelodysplastic syndromes by Nimer, Stephen D.

“…There has been a remarkable explosion of knowledge into the molecular defects that underlie the acute and chronic leukemias, leading to the introduction of…”
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Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation by Moran-Crusio, Kelly, Reavie, Linsey, Shih, Alan, Abdel-Wahab, Omar, Ndiaye-Lobry, Delphine, Lobry, Camille, Figueroa, Maria E., Vasanthakumar, Aparna, Patel, Jay, Zhao, Xinyang, Perna, Fabiana, Pandey, Suveg, Madzo, Jozef, Song, Chunxiao, Dai, Qing, He, Chuan, Ibrahim, Sherif, Beran, Miloslav, Zavadil, Jiri, Nimer, Stephen D., Melnick, Ari, Godley, Lucy A., Aifantis, Iannis, Levine, Ross L.

“…Somatic loss-of-function mutations in the ten-eleven translocation 2 ( TET2) gene occur in a significant proportion of patients with myeloid malignancies…”
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ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression by Abdel-Wahab, Omar, Adli, Mazhar, LaFave, Lindsay M., Gao, Jie, Hricik, Todd, Shih, Alan H., Pandey, Suveg, Patel, Jay P., Chung, Young Rock, Koche, Richard, Perna, Fabiana, Zhao, Xinyang, Taylor, Jordan E., Park, Christopher Y., Carroll, Martin, Melnick, Ari, Nimer, Stephen D., Jaffe, Jacob D., Aifantis, Iannis, Bernstein, Bradley E., Levine, Ross L.

“…Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated…”
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Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia by Shih, Alan H., Jiang, Yanwen, Meydan, Cem, Shank, Kaitlyn, Pandey, Suveg, Barreyro, Laura, Antony-Debre, Ileana, Viale, Agnes, Socci, Nicholas, Sun, Yongming, Robertson, Alexander, Cavatore, Magali, de Stanchina, Elisa, Hricik, Todd, Rapaport, Franck, Woods, Brittany, Wei, Chen, Hatlen, Megan, Baljevic, Muhamed, Nimer, Stephen D., Tallman, Martin, Paietta, Elisabeth, Cimmino, Luisa, Aifantis, Iannis, Steidl, Ulrich, Mason, Chris, Melnick, Ari, Levine, Ross L.

“…Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and TET2 mutations, confer distinct biologic features and adverse…”
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Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies by Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

“…Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of myeloid malignancies associated with poor prognosis. We generated a Vav1…”
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DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling by Guryanova, Olga A, Shank, Kaitlyn, Spitzer, Barbara, Luciani, Luisa, Koche, Richard P, Garrett-Bakelman, Francine E, Ganzel, Chezi, Durham, Benjamin H, Mohanty, Abhinita, Hoermann, Gregor, Rivera, Sharon A, Chramiec, Alan G, Pronier, Elodie, Bastian, Lennart, Keller, Matthew D, Tovbin, Daniel, Loizou, Evangelia, Weinstein, Abby R, Gonzalez, Adriana Rodriguez, Lieu, Yen K, Rowe, Jacob M, Pastore, Friederike, McKenney, Anna Sophia, Krivtsov, Andrei V, Sperr, Wolfgang R, Cross, Justin R, Mason, Christopher E, Tallman, Martin S, Arcila, Maria E, Abdel-Wahab, Omar, Armstrong, Scott A, Kubicek, Stefan, Staber, Philipp B, Gönen, Mithat, Paietta, Elisabeth M, Melnick, Ari M, Nimer, Stephen D, Mukherjee, Siddhartha, Levine, Ross L

“…AML cells carrying R882 mutations in DNMT3A fail to sense and repair DNA damage induced by standard-dose chemotherapy as a result of impaired chromatin…”
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PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes by Hamard, Pierre-Jacques, Santiago, Gabriel E., Liu, Fan, Karl, Daniel L., Martinez, Concepcion, Man, Na, Mookhtiar, Adnan K., Duffort, Stephanie, Greenblatt, Sarah, Verdun, Ramiro E., Nimer, Stephen D.

“…Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including…”
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Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis by Liu, Fan, Cheng, Guoyan, Hamard, Pierre-Jacques, Greenblatt, Sarah, Wang, Lan, Man, Na, Perna, Fabiana, Xu, Haiming, Tadi, Madhavi, Luciani, Luisa, Nimer, Stephen D

“…Epigenetic regulators play critical roles in normal hematopoiesis, and the activity of these enzymes is frequently altered in hematopoietic cancers. The major…”
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Heterodimeric JAK–STAT activation as a mechanism of persistence to JAK2 inhibitor therapy by Koppikar, Priya, Bhagwat, Neha, Kilpivaara, Outi, Manshouri, Taghi, Adli, Mazhar, Hricik, Todd, Liu, Fan, Saunders, Lindsay M., Mullally, Ann, Abdel-Wahab, Omar, Leung, Laura, Weinstein, Abby, Marubayashi, Sachie, Goel, Aviva, Gönen, Mithat, Estrov, Zeev, Ebert, Benjamin L., Chiosis, Gabriela, Nimer, Stephen D., Bernstein, Bradley E., Verstovsek, Srdan, Levine, Ross L.

“…Chronic exposure to JAK2 inhibitors leads to reactivation of downstream signalling through the formation of heterodimers between JAK2 and other JAK kinases in…”
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Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3 by FISCHER, Thomas, STONE, Richard M, KLIMEK, Virginia M, NIMER, Stephen D, GILLILAND, D. Gary, DUTREIX, Catherine, HUNTSMAN-LABED, Alice, VIRKUS, Jodi, GILES, Francis J, DEANGELO, Daniel J, GALINSKY, Ilene, ESTEY, Elihu, LANZA, Carlo, FOX, Edward, EHNINGER, Gerhard, FELDMAN, Eric J, SCHILLER, Gary J

“…Mutations leading to constitutive activation of the FMS-like tyrosine kinase 3 receptor (FLT3) occur in blasts of 30% of patients with acute myeloid leukemia…”
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Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer by Chen, Chuan, Man, Na, Liu, Fan, Martin, Gloria Mas, Itonaga, Hidehiro, Sun, Jun, Nimer, Stephen D

“…Innate immune cells participate in the detection of tumor cells via complex signaling pathways mediated by pattern-recognition receptors, such as Toll-like…”
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Arginine methyltransferases in normal and malignant hematopoiesis by Greenblatt, Sarah M, Liu, Fan, Nimer, Stephen D

“…Arginine methylation is an abundant covalent modification that regulates diverse cellular processes, including transcription, translation, DNA repair, and RNA…”
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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice by Zhao, Zhigang, Chen, Li, Dawlaty, Meelad M., Pan, Feng, Weeks, Ophelia, Zhou, Yuan, Cao, Zeng, Shi, Hui, Wang, Jiapeng, Lin, Li, Chen, Shi, Yuan, Weiping, Qin, Zhaohui, Ni, Hongyu, Nimer, Stephen D., Yang, Feng-Chun, Jaenisch, Rudolf, Jin, Peng, Xu, Mingjiang

“…TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in…”
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JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation by Liu, Fan, Zhao, Xinyang, Perna, Fabiana, Wang, Lan, Koppikar, Priya, Abdel-Wahab, Omar, Harr, Michael W., Levine, Ross L., Xu, Hao, Tefferi, Ayalew, Deblasio, Anthony, Hatlen, Megan, Menendez, Silvia, Nimer, Stephen D.

“…The JAK2V617F constitutively activated tyrosine kinase is found in most patients with myeloproliferative neoplasms. While examining the interaction between…”
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HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia by Zhu, Ganqian, Luo, Huacheng, Feng, Yang, Guryanova, Olga A., Xu, Jianfeng, Chen, Shi, Lai, Qian, Sharma, Arati, Xu, Bing, Zhao, Zhigang, Feng, Ru, Ni, Hongyu, Claxton, David, Guo, Ying, Mesa, Ruben A., Qiu, Yi, Yang, Feng-Chun, Li, Wei, Nimer, Stephen D., Huang, Suming, Xu, Mingjiang

“…Nucleophosmin ( NPM1 ) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting in aberrant cytoplasmic translocation of the encoded…”
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The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis by Sun, Xiao-Jian, Man, Na, Tan, Yurong, Nimer, Stephen D, Wang, Lan

“…Histone, and non-histone, protein acetylation plays an important role in a variety of cellular events, including the normal and abnormal development of blood…”
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The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation by Wang, Lan, Gural, Alexander, Sun, Xiao-Jian, Zhao, Xinyang, Perna, Fabiana, Huang, Gang, Hatlen, Megan A., Vu, Ly, Liu, Fan, Xu, Haiming, Asai, Takashi, Xu, Hao, Deblasio, Tony, Menendez, Silvia, Voza, Francesca, Jiang, Yanwen, Cole, Philip A., Zhang, Jinsong, Melnick, Ari, Roeder, Robert G., Nimer, Stephen D.

“…The chromosomal translocations found in acute myelogenous leukemia (AML) generate oncogenic fusion transcription factors with aberrant transcriptional…”
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A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis by Sun, Xiao-Jian, Wang, Zhanxin, Wang, Lan, Jiang, Yanwen, Kost, Nils, Soong, T. David, Chen, Wei-Yi, Tang, Zhanyun, Nakadai, Tomoyoshi, Elemento, Olivier, Fischle, Wolfgang, Melnick, Ari, Patel, Dinshaw J., Nimer, Stephen D., Roeder, Robert G.

“…A multiprotein complex containing AML1–ETO, the most common fusion protein found in acute myeloid leukaemia, is revealed and analysed in leukaemic cells, and a…”
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An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia by Gruber, Tanja A., Larson Gedman, Amanda, Zhang, Jinghui, Koss, Cary S., Marada, Suresh, Ta, Huy Q., Chen, Shann-Ching, Su, Xiaoping, Ogden, Stacey K., Dang, Jinjun, Wu, Gang, Gupta, Vedant, Andersson, Anna K., Pounds, Stanley, Shi, Lei, Easton, John, Barbato, Michael I., Mulder, Heather L., Manne, Jayanthi, Wang, Jianmin, Rusch, Michael, Ranade, Swati, Ganti, Ramapriya, Parker, Matthew, Ma, Jing, Radtke, Ina, Ding, Li, Cazzaniga, Giovanni, Biondi, Andrea, Kornblau, Steven M., Ravandi, Farhad, Kantarjian, Hagop, Nimer, Stephen D., Döhner, Konstanze, Döhner, Hartmut, Ley, Timothy J., Ballerini, Paola, Shurtleff, Sheila, Tomizawa, Daisuke, Adachi, Souichi, Hayashi, Yasuhide, Tawa, Akio, Shih, Lee-Yung, Liang, Der-Cherng, Rubnitz, Jeffrey E., Pui, Ching-Hon, Mardis, Elaine R., Wilson, Richard K., Downing, James R.

“…To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts…”
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The p53 tumor suppressor protein regulates hematopoietic stem cell fate by Asai, Takashi, Liu, Yan, Bae, Narae, Nimer, Stephen D.

“…The p53 tumor suppressor protein is a key transcription factor that regulates several signaling pathways involved in the cell's response to stress. Through…”
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