Search Results - "Nimer, SD"

Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412 by Stone, Richard M., DeAngelo, Daniel J., Klimek, Virginia, Galinsky, Ilene, Estey, Eli, Nimer, Stephen D., Grandin, Wilson, Lebwohl, David, Wang, Yanfeng, Cohen, Pamela, Fox, Edward A., Neuberg, Donna, Clark, Jennifer, Gilliland, D. Gary, Griffin, James D.

“…Leukemic cells from 30% of patients with acute myeloid leukemia (AML) have an activating mutation in the FLT3 (fms-like tyrosine kinase) gene, which represents…”
Get full text

Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma by Kewalramani, Tarun, Zelenetz, Andrew D., Nimer, Stephen D., Portlock, Carol, Straus, David, Noy, Ariela, O'Connor, Owen, Filippa, Daniel A., Teruya-Feldstein, Julie, Gencarelli, Alison, Qin, Jing, Waxman, Alyson, Yahalom, Joachim, Moskowitz, Craig H.

“…Patients with relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL) who achieve complete response (CR) before autologous stem cell…”
Get full text

Transforming Growth Factor β-Induced Cell Cycle Arrest of Human Hematopoietic Cells Requires p57KIP2 Up-Regulation by Scandura, Joseph M., Boccuni, Piernicola, Massagué, Joan, Nimer, Stephen D.

“…Transforming growth factor β (TGFβ) is one of few known negative regulators of hematopoiesis, yet the mechanisms by which it affects cell cycle arrest and stem…”
Get full text

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1 by Kalakonda, N, Fischle, W, Boccuni, P, Gurvich, N, Hoya-Arias, R, Zhao, X, Miyata, Y, MacGrogan, D, Zhang, J, Sims, J K, Rice, J C, Nimer, S D

“…Lethal 3 malignant brain tumor 1 (L3MBTL1), a homolog of the Drosophila polycomb tumor suppressor l(3) mbt, contains three tandem MBT repeats (3xMBT) that are…”
Get full text

The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells by Lacorazza, H. Daniel, Yamada, Takeshi, Liu, Yan, Miyata, Yasuhiko, Sivina, Mariela, Nunes, Juliana, Nimer, Stephen D.

“…The transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is largely unknown. We report that the transcription factor known as…”
Get full text

Intensive Methotrexate and Cytarabine Followed by High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Patients With Newly Diagnosed Primary CNS Lymphoma: An Intent-to-Treat Analysis by ABREY, Lauren E, MOSKOWITZ, Craig H, ZELENETZ, Andrew, NIMER, Stephen D, DEANGELIS, Lisa M, MASON, Warren P, CRUMP, Michael, STEWART, Douglas, FORSYTH, Peter, PALEOLOGOS, Nina, CORREA, Denise D, ANDERSON, Nicole D, CARON, Dawn

“…To assess the safety and efficacy of intensive methotrexate-based chemotherapy followed by high-dose chemotherapy (HDT) with autologous stem-cell rescue in…”
Get full text

Transcription Factors, Translocations, and Leukemia by Nichols, Joni, Nimer, Stephen D.

“…The frequent occurrence of TF gene involvement in translocations associated with leukemia is remarkable, although not yet explained. The wide variety of TFs…”
Get full text

Age-adjusted International Prognostic Index predicts autologous stem cell transplantation outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma by Hamlin, Paul A., Zelenetz, Andrew D., Kewalramani, Tarun, Qin, Jing, Satagopan, Jaya M., Verbel, David, Noy, Ariela, Portlock, Carol S., Straus, David J., Yahalom, Joachim, Nimer, Stephen D., Moskowitz, Craig H.

“…Second-line chemotherapy followed by high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) cures less than half of the patients with…”
Get full text

Effectiveness of high dose chemoradiotherapy and autologous stem cell transplantation for patients with biopsy‐proven primary refractory Hodgkin's disease by Moskowitz, Craig H., Kewalramani, Tarun, Nimer, Stephen D., Gonzalez, Maria, Zelenetz, Andrew D., Yahalom, Joachim

“…Summary Prospective randomized studies have determined that high dose therapy and autologous stem cell transplantation (ASCT) is the standard treatment for…”
Get full text

Report of an international working group to standardize response criteria for myelodysplastic syndromes by Cheson, Bruce D., Bennett, John M., Kantarjian, Hagop, Pinto, Antonio, Schiffer, Charles A., Nimer, Stephen D., Löwenberg, Bob, Beran, Miroslav, de Witte, Theo M., Stone, Richard M., Mittelman, Moshe, Sanz, Guillermo F., Wijermans, Pierre W., Gore, Steven, Greenberg, Peter L.

“…Standardized criteria for assessing response are essential to ensure comparability among clinical trials for patients with myelodysplastic syndromes (MDS). An…”
Get full text

A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease: analysis by intent to treat and development of a prognostic model by Moskowitz, Craig H., Nimer, Stephen D., Zelenetz, Andrew D., Trippett, Tania, Hedrick, Eric E., Filippa, Daniel A., Louie, Diane, Gonzales, Maria, Walits, Janine, Coady-Lyons, Nancy, Qin, Jing, Frank, Richard, Bertino, Joseph R., Goy, Andre, Noy, Ariela, O'Brien, James P., Straus, David, Portlock, Carol S., Yahalom, Joachim

“…Salvage of patients with relapsed and refractory Hodgkin disease (HD) with high-dose chemoradiotherapy (HDT) and autologous stem cell transplantation (ASCT)…”
Get full text

The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer and NK-T Cells by Lacorazza, H.Daniel, Miyazaki, Yasushi, Di Cristofano, Antonio, Deblasio, Anthony, Hedvat, Cyrus, Zhang, Jin, Cordon-Cardo, Carlos, Mao, Shifeng, Pandolfi, Pier Paolo, Nimer, Stephen D.

“…We utilized gene targeting by homologous recombination to define the role that MEF, a transcriptional activating member of the ETS family of transcription…”
Get full text

An increased HLA DR2 frequency is seen in aplastic anemia patients by NIMER, S. D, IRELAND, P, AZIN MESHKINPOUR, FRANE, M

“…The underlying etiology of aplastic anemia is unknown in the majority of patients, although medications, chemical exposure, or viral infections can be…”
Get full text

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells by Mulloy, James C., Cammenga, Jörg, MacKenzie, Karen L., Berguido, Francisco J., Moore, Malcolm A.S., Nimer, Stephen D.

“…The acute myelogenous leukemia–1 (AML1)–ETO fusion protein is generated by the t(8;21), which is found in 40% of AMLs of the French-American-British M2…”
Get full text

Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML) by Kindler, Thomas, Breitenbuecher, Frank, Kasper, Stefan, Estey, Eli, Giles, Francis, Feldman, Eric, Ehninger, Gerhard, Schiller, Gary, Klimek, Virginia, Nimer, Stephen D., Gratwohl, Alois, Choudhary, Chuna Ram, Mueller-Tidow, Constan, Serve, Hubert, Gschaidmeier, Harald, Cohen, Pamela S., Huber, Christoph, Fischer, Thomas

“…Fms-like tyrosine kinase 3 (FLT3) receptor mutations as internal tandem duplication (ITD) or within the kinase domain are detected in up to 35% of patients…”
Get full text

Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q) by Fenaux, Pierre, Giagounidis, Aristoteles, Selleslag, Dominik, Beyne-Rauzy, Odile, Mittelman, Moshe, Muus, Petra, Nimer, Stephen D, Hellström-Lindberg, Eva, Powell, Bayard L, Guerci-Bresler, Agnes, Sekeres, Mikkael A, Deeg, H Joachim, Del Cañizo, Consuelo, Greenberg, Peter L, Shammo, Jamile M, Skikne, Barry, Yu, Xujie, List, Alan F

“…Particularly since the advent of lenalidomide, lower-risk myelodysplastic syndromes (MDS) patients with del(5q) have been the focus of many studies; however,…”
Get full text

Maintaining the self-renewal and differentiation potential of human CD34+hematopoietic cells using a single genetic element by Mulloy, James C., Cammenga, Jorg, Berguido, Francisco J., Wu, Kaida, Zhou, Ping, Comenzo, Raymond L., Jhanwar, Suresh, Moore, Malcolm A.S., Nimer, Stephen D.

“…Hematopoiesis is a complex process involving hematopoietic stem cell (HSC) self-renewal and lineage commitment decisions that must continue throughout life…”
Get full text

Severe and selective deficiency of interferon‐γ‐producing invariant natural killer T cells in patients with myelodysplastic syndromes by Fujii, Shin‐ichiro, Shimizu, Kanako, Klimek, Virginia, Geller, Matthew D., Nimer, Stephen D., V. Dhodapkar, Madhav

“…Here we show that patients with myelodysplastic syndromes (MDS) have a severe deficiency of glycolipid reactive Vα24+/Vβ11+ natural killer T (NKT) cells, but…”
Get full text

The Human L(3)MBT Polycomb Group Protein Is a Transcriptional Repressor and Interacts Physically and Functionally with TEL (ETV6) by Boccuni, Piernicola, MacGrogan, Donal, Scandura, Joseph M., Nimer, Stephen D.

“…H-L(3)MBT, the human homolog of theDrosophila lethal(3)malignant brain tumor protein, is a member of the polycomb group (PcG) of proteins, which function as…”
Get full text

Progressive disease following autologous transplantation in patients with chemosensitive relapsed or primary refractory Hodgkin's disease or aggressive non-Hodgkin's lymphoma by KEWALRAMANI, T, NIMER, S. D, ZELENETZ, A. D, MALHOTRA, S, QIN, J, YAHALOM, J, MOSKOWITZ, C. H

“…To determine the outcome of patients with chemosensitive relapsed or primary refractory Hodgkin's disease (HD) or aggressive non-Hodgkin's lymphoma (NHL) whose…”
Get full text