Search Results - "Nilsson, Ulf J."

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease by Boza-Serrano, Antonio, Ruiz, Rocío, Sanchez-Varo, Raquel, García-Revilla, Juan, Yang, Yiyi, Jimenez-Ferrer, Itzia, Paulus, Agnes, Wennström, Malin, Vilalta, Anna, Allendorf, David, Davila, Jose Carlos, Stegmayr, John, Jiménez, Sebastian, Roca-Ceballos, Maria A., Navarro-Garrido, Victoria, Swanberg, Maria, Hsieh, Christine L., Real, Luis M., Englund, Elisabet, Linse, Sara, Leffler, Hakon, Nilsson, Ulf J., Brown, Guy C., Gutierrez, Antonia, Vitorica, Javier, Venero, Jose Luis, Deierborg, Tomas

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary…”
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Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding by Verteramo, Maria Luisa, Stenström, Olof, Ignjatović, Majda Misini, Caldararu, Octav, Olsson, Martin A, Manzoni, Francesco, Leffler, Hakon, Oksanen, Esko, Logan, Derek T, Nilsson, Ulf J, Ryde, Ulf, Akke, Mikael

“…Understanding the driving forces underlying molecular recognition is of fundamental importance in chemistry and biology. The challenge is to unravel the…”
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Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3 by MACKINNON, Alison C, GIBBONS, Michael A, SETHI, Tariq, FARNWORTH, Sarah L, LEFFLER, Hakon, NILSSON, Uif J, DELAINE, Tamara, JOHN SIMPSON, A, FORBES, Stuart J, HIRANI, Nik, GAULDIE, Jack

“…Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar epithelial injury with differentiation of epithelial cells and fibroblasts…”
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Ligand Induced Galectin-3 Protein Self-association by Lepur, Adriana, Salomonsson, Emma, Nilsson, Ulf J., Leffler, Hakon

“…Many functions of galectin-3 entail binding of its carbohydrate recognition site to glycans of a glycoprotein, resulting in cross-linking thought to be…”
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Novel Selective Galectin‑3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia by Bum-Erdene, Khuchtumur, Collins, Patrick M, Hugo, Matthew W, Tarighat, Somayeh S, Fei, Fei, Kishor, Chandan, Leffler, Hakon, Nilsson, Ulf. J, Groffen, John, Grice, I. Darren, Heisterkamp, Nora, Blanchard, Helen

“…Galectin-3 is a β-galactoside-specific, carbohydrate-recognizing protein (lectin) that is strongly implicated in cancer development, metastasis, and drug…”
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Extracellular and intracellular small-molecule galectin-3 inhibitors by Stegmayr, John, Zetterberg, Fredrik, Carlsson, Michael C., Huang, Xiaoli, Sharma, Gunjan, Kahl-Knutson, Barbro, Schambye, Hans, Nilsson, Ulf J., Oredsson, Stina, Leffler, Hakon

“…Galectin-3 is a carbohydrate binding protein which has important roles in cancer and immunity. Potent galectin-3 inhibitors have been synthesized, for…”
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Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3 by Chen, Wei-Sheng, Cao, Zhiyi, Sugaya, Satoshi, Lopez, Maria J., Sendra, Victor G., Laver, Nora, Leffler, Hakon, Nilsson, Ulf J., Fu, Jianxin, Song, Jianhua, Xia, Lijun, Hamrah, Pedram, Panjwani, Noorjahan

“…Lymphangiogenesis plays a pivotal role in diverse pathological conditions. Here, we demonstrate that a carbohydrate-binding protein, galectin-8, promotes…”
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A Selective Galactose–Coumarin-Derived Galectin‑3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model by Rajput, Vishal K, MacKinnon, Alison, Mandal, Santanu, Collins, Patrick, Blanchard, Helen, Leffler, Hakon, Sethi, Tariq, Schambye, Hans, Mukhopadhyay, Balaram, Nilsson, Ulf J

“…Synthesis of doubly 3-O-coumarylmethyl-substituted thiodigalactosides from bis-3-O-propargyl-thiodigalactoside resulted in highly selective and high affinity…”
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Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3 by Diehl, Carl, Engström, Olof, Delaine, Tamara, Håkansson, Maria, Genheden, Samuel, Modig, Kristofer, Leffler, Hakon, Ryde, Ulf, Nilsson, Ulf J, Akke, Mikael

“…Rational drug design is predicated on knowledge of the three-dimensional structure of the protein−ligand complex and the thermodynamics of ligand binding…”
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Structural characterization of human galectin‐4 C‐terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens by Bum‐Erdene, Khuchtumur, Leffler, Hakon, Nilsson, Ulf J, Blanchard, Helen

“…Human galectin‐4 is a lectin that is expressed mainly in the gastrointestinal tract and exhibits metastasis‐promoting roles in some cancers. Its tandem‐repeat…”
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Regulation of Alternative Macrophage Activation by Galectin-3 by MacKinnon, Alison C, Farnworth, Sarah L, Hodkinson, Philip S, Henderson, Neil C, Atkinson, Kirsten M, Leffler, Hakon, Nilsson, Ulf J, Haslett, Christopher, Forbes, Stuart J, Sethi, Tariq

“…Alternative macrophage activation is implicated in diverse disease pathologies such as asthma, organ fibrosis, and granulomatous diseases, but the mechanisms…”
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The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics by Saraboji, Kadhirvel, Håkansson, Maria, Genheden, Samuel, Diehl, Carl, Qvist, Johan, Weininger, Ulrich, Nilsson, Ulf J, Leffler, Hakon, Ryde, Ulf, Akke, Mikael, Logan, Derek T

“…The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of…”
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Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C by Wallerstein, Johan, Ekberg, Vilhelm, Ignjatović, Majda Misini, Kumar, Rohit, Caldararu, Octav, Peterson, Kristoffer, Wernersson, Sven, Brath, Ulrika, Leffler, Hakon, Oksanen, Esko, Logan, Derek T., Nilsson, Ulf J., Ryde, Ulf, Akke, Mikael

“…Molecular recognition is fundamental to biological signaling. A central question is how individual interactions between molecular moieties affect the…”
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A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1 by Pal, Kumar Bhaskar, Mahanti, Mukul, Leffler, Hakon, Nilsson, Ulf J

“…Galectins are a family of galactoside-recognizing proteins involved in different galectin-subtype-specific inflammatory and tumor-promoting processes, which…”
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Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site by Wahlgren, Weixiao Y., Dunevall, Elin, North, Rachel A., Paz, Aviv, Scalise, Mariafrancesca, Bisignano, Paola, Bengtsson-Palme, Johan, Goyal, Parveen, Claesson, Elin, Caing-Carlsson, Rhawnie, Andersson, Rebecka, Beis, Konstantinos, Nilsson, Ulf J., Farewell, Anne, Pochini, Lorena, Indiveri, Cesare, Grabe, Michael, Dobson, Renwick C. J., Abramson, Jeff, Ramaswamy, S., Friemann, Rosmarie

“…Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise…”
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Galectin‐3 type‐C self‐association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function by Sundqvist, Martina, Welin, Amanda, Elmwall, Jonas, Osla, Veronica, Nilsson, Ulf J., Leffler, Hakon, Bylund, Johan, Karlsson, Anna

“…Galectin‐3 is an endogenous β‐galactoside‐binding lectin comprising a carbohydrate recognition domain (CRD) linked to a collagen‐like N‐domain. Both domains…”
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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1 by Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.

“…Background Galectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been…”
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Development of a novel AAK1 inhibitor via Kinobeads-based screening by Yoshida, Akari, Ohtsuka, Satomi, Matsumoto, Fumiya, Miyagawa, Tomoyuki, Okino, Rei, Ikeda, Yumeya, Tada, Natsume, Gotoh, Akira, Magari, Masaki, Hatano, Naoya, Morishita, Ryo, Satoh, Ayano, Sunatsuki, Yukinari, Nilsson, Ulf J., Ishikawa, Teruhiko, Tokumitsu, Hiroshi

“…A chemical proteomics approach using Ca 2+ /calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified…”
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Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance by Kim, Henry, Kretz, Louis, Ronin, Céline, Starck, Christina, Roper, James A, Kahl-Knutson, Barbro, Peterson, Kristoffer, Leffler, Hakon, Nilsson, Ulf J, Pedersen, Anders, Zetterberg, Fredrik R, Slack, Robert J

“…The beta-galactoside-binding mammalian lectin galectin-1 can bind, via its carbohydrate recognition domain (CRD), to various cell surface glycoproteins and has…”
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Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model by Stannard, Kimberley A, Collins, Patrick M, Ito, Koichi, Sullivan, Emily M, Scott, Stacy A, Gabutero, Elwyn, Darren Grice, I, Low, Pauline, Nilsson, Ulf. J, Leffler, Hakon, Blanchard, Helen, Ralph, Stephen J

“…Abstract High level galectin-1 expression results in cancer cell evasion of the immune response, increased tumour survival and aggressive metastases. Using a…”
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