Search Results - "Nilsson, Susan K."

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming by Liu, Xiaodong, Nefzger, Christian M, Rossello, Fernando J, Chen, Joseph, Knaupp, Anja S, Firas, Jaber, Ford, Ethan, Pflueger, Jahnvi, Paynter, Jacob M, Chy, Hun S, O'Brien, Carmel M, Huang, Cheng, Mishra, Ketan, Hodgson-Garms, Margeaux, Jansz, Natasha, Williams, Sarah M, Blewitt, Marnie E, Nilsson, Susan K, Schittenhelm, Ralf B, Laslett, Andrew L, Lister, Ryan, Polo, Jose M

“…This study compares naive human pluripotent stem cells, either reprogrammed directly from somatic cells or converted from primed cells, under a variety of…”
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MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells by Sheikh, Bilal N., Yang, Yuqing, Schreuder, Jaring, Nilsson, Susan K., Bilardi, Rebecca, Carotta, Sebastian, McRae, Helen M., Metcalf, Donald, Voss, Anne K., Thomas, Tim

“…Hematopoietic stem cells (HSCs) are conventionally thought to be at the apex of a hierarchy that produces all mature cells of the blood. The quintessential…”
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High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production by Heazlewood, Shen Y., Ahmad, Tanveer, Cao, Benjamin, Cao, Huimin, Domingues, Melanie, Sun, Xuan, Heazlewood, Chad K., Li, Songhui, Williams, Brenda, Fulton, Madeline, White, Jacinta F., Nebl, Tom, Nefzger, Christian M., Polo, Jose M., Kile, Benjamin T., Kraus, Felix, Ryan, Michael T., Sun, Yu B., Choong, Peter F. M., Ellis, Sarah L., Anko, Minna-Liisa, Nilsson, Susan K.

“…Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large…”
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Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells by Sun, Xuan, Cao, Benjamin, Naval-Sanchez, Marina, Pham, Tony, Sun, Yu Bo Yang, Williams, Brenda, Heazlewood, Shen Y., Deshpande, Nikita, Li, Jinhua, Kraus, Felix, Rae, James, Nguyen, Quan, Yari, Hamed, Schröder, Jan, Heazlewood, Chad K., Fulton, Madeline, Hatwell-Humble, Jessica, Das Gupta, Kaustav, Kapetanovic, Ronan, Chen, Xiaoli, Sweet, Matthew J., Parton, Robert G., Ryan, Michael T., Polo, Jose M., Nefzger, Christian M., Nilsson, Susan K.

“…With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced regenerative potential and loss of quiescence, which is accompanied by…”
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Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere by Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul, Williams, Craig M.

“…Pharmaceutical and agrochemical discovery programs are under considerable pressure to meet increasing global demand and thus require constant innovation…”
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Analyzing hematopoietic stem cell homing, lodgment, and engraftment to better understand the bone marrow niche by Heazlewood, Shen Y., Oteiza, Ana, Cao, Huimin, Nilsson, Susan K.

“…The existence of a bone marrow (BM) niche—the location in which hematopoietic stem cells (HSCs) reside—was proposed more than 30 years ago. Recent data suggest…”
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Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist by Cao, Benjamin, Zhang, Zhen, Grassinger, Jochen, Williams, Brenda, Heazlewood, Chad K., Churches, Quentin I., James, Simon A., Li, Songhui, Papayannopoulou, Thalia, Nilsson, Susan K.

“…The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for hematopoietic stem cell (HSC) mobilization have driven efforts to…”
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NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates by Boghdadi, Anthony G., Spurrier, Joshua, Teo, Leon, Li, Mingfeng, Skarica, Mario, Cao, Benjamin, Kwan, William C., Merson, Tobias D., Nilsson, Susan K., Sestan, Nenad, Strittmatter, Stephen M., Bourne, James A.

“…Astrocytes play critical roles after brain injury, but their precise function is poorly defined. Utilizing single-nuclei transcriptomics to characterize…”
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The relationship between bone, hemopoietic stem cells, and vasculature by Ellis, Sarah L., Grassinger, Jochen, Jones, Allan, Borg, Judy, Camenisch, Todd, Haylock, David, Bertoncello, Ivan, Nilsson, Susan K.

“…A large body of evidence suggests hemopoietic stem cells (HSCs) exist in an endosteal niche close to bone, whereas others suggest that the HSC niche is…”
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Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes by Westhorpe, Clare L. V., Norman, M. Ursula, Hall, Pam, Snelgrove, Sarah L., Finsterbusch, Michaela, Li, Anqi, Lo, Camden, Tan, Zhe Hao, Li, Songhui, Nilsson, Susan K., Kitching, A. Richard, Hickey, Michael J.

“…Although effector CD4 + T cells readily respond to antigen outside the vasculature, how they respond to intravascular antigens is unknown. Here we show the…”
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Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding by Wan, Ho-Ying, Chen, Jack Chun Hin, Xiao, Qinru, Wong, Christy Wingtung, Yang, Boguang, Cao, Benjamin, Tuan, Rocky S, Nilsson, Susan K, Ho, Yi-Ping, Raghunath, Michael, Kamm, Roger D, Blocki, Anna

“…There is great interest to engineer in vitro models that allow the study of complex biological processes of the microvasculature with high spatiotemporal…”
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Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells by Nilsson, Susan K., Johnston, Hayley M., Whitty, Genevieve A., Williams, Brenda, Webb, Ryan J., Denhardt, David T., Bertoncello, Ivan, Bendall, Linda J., Simmons, Paul J., Haylock, David N.

“…Although recent data suggests that osteoblasts play a key role within the hematopoietic stem cell (HSC) niche, the mechanisms underpinning this remain to be…”
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The role of CD44 in fetal and adult hematopoietic stem cell regulation by Cao, Huimin, Heazlewood, Shen Y, Williams, Brenda, Cardozo, Daniela, Nigro, Julie, Oteiza, Ana, Nilsson, Susan K

“…Throughout development, hematopoietic stem cells migrate to specific microenvironments, where their fate is, in part, extrinsically controlled. CD44 standard…”
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Haemopedia: An Expression Atlas of Murine Hematopoietic Cells by de Graaf, Carolyn A., Choi, Jarny, Baldwin, Tracey M., Bolden, Jessica E., Fairfax, Kirsten A., Robinson, Aaron J., Biben, Christine, Morgan, Clare, Ramsay, Kerry, Ng, Ashley P., Kauppi, Maria, Kruse, Elizabeth A., Sargeant, Tobias J., Seidenman, Nick, D'Amico, Angela, D'Ombrain, Marthe C., Lucas, Erin C., Koernig, Sandra, Baz Morelli, Adriana, Wilson, Michael J., Dower, Steven K., Williams, Brenda, Heazlewood, Shen Y., Hu, Yifang, Nilsson, Susan K., Wu, Li, Smyth, Gordon K., Alexander, Warren S., Hilton, Douglas J.

“…Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present…”
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Osteopontin: a bridge between bone and blood by Haylock, David N., Nilsson, Susan K.

“…Summary The production of mature blood cells within the bone marrow (BM) is attributed to a pool of haemopoietic stem cells (HSC). It is now evident that HSC…”
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Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential by Grassinger, Jochen, Haylock, David N., Williams, Brenda, Olsen, Gemma H., Nilsson, Susan K.

“…Hemopoietic stem cells (HSCs) reside within a specified area of the bone marrow (BM) cavity called a “niche” that modulates HSC quiescence, proliferation,…”
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Endogenous Fibroblastic Progenitor Cells in the Adult Mouse Lung Are Highly Enriched in the Sca‐1 Positive Cell Fraction by McQualter, Jonathan L., Brouard, Nathalie, Williams, Brenda, Baird, Brandi N., Sims‐Lucas, Sunder, Yuen, Karen, Nilsson, Susan K., Simmons, Paul J., Bertoncello, Ivan

“…Originally identified as a marker specifying murine hematopoietic stem cells, the Sca‐1 antigen has since been shown to be differentially expressed by…”
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3D-cardiomics: A spatial transcriptional atlas of the mammalian heart by Mohenska, Monika, Tan, Nathalia M., Tokolyi, Alex, Furtado, Milena B., Costa, Mauro W., Perry, Andrew J., Hatwell-Humble, Jessica, van Duijvenboden, Karel, Nim, Hieu T., Ji, Yuan M.M., Charitakis, Natalie, Bienroth, Denis, Bolk, Francesca, Vivien, Celine, Knaupp, Anja S., Powell, David R., Elliott, David A., Porrello, Enzo R., Nilsson, Susan K., del Monte-Nieto, Gonzalo, Rosenthal, Nadia A., Rossello, Fernando J., Polo, Jose M., Ramialison, Mirana

“…Understanding the spatial gene expression and regulation in the heart is key to uncovering its developmental and physiological processes, during homeostasis…”
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Cell Type of Origin Dictates the Route to Pluripotency by Nefzger, Christian M., Rossello, Fernando J., Chen, Joseph, Liu, Xiaodong, Knaupp, Anja S., Firas, Jaber, Paynter, Jacob M., Pflueger, Jahnvi, Buckberry, Sam, Lim, Sue Mei, Williams, Brenda, Alaei, Sara, Faye-Chauhan, Keshav, Petretto, Enrico, Nilsson, Susan K., Lister, Ryan, Ramialison, Mirana, Powell, David R., Rackham, Owen J.L., Polo, Jose M.

“…Our current understanding of induced pluripotent stem cell (iPSC) generation has almost entirely been shaped by studies performed on reprogramming fibroblasts…”
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Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy by Jiang, Mengjie, Fan, Jinjin, Qu, Xinli, Li, Songhui, Nilsson, Susan K, Sun, Yu Bo Yang, Chen, Yaping, Yu, Di, Liu, Dan, Liu, Bi-Cheng, Tang, Mingliang, Chen, Wei, Ren, Yi, Nikolic-Paterson, David J, Jiang, Xiaoyun, Li, Jinhua, Yu, Xueqing

“…Acute kidney injury leading to chronic kidney disease through tubulointerstitial fibrosis is a major challenge in nephropathy. Several signaling pathways…”
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