Search Results - "Nilsson, Per H."

The Role of Complement in Liver Injury, Regeneration, and Transplantation by Thorgersen, Ebbe Billmann, Barratt‐Due, Andreas, Haugaa, Håkon, Harboe, Morten, Pischke, Søren Erik, Nilsson, Per H., Mollnes, Tom Eirik

“…The liver is both an immunologically complex and a privileged organ. The innate immune system is a central player, in which the complement system emerges as a…”
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Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications by Sharifi, Sina, Islam, Mohammad Mirazul, Sharifi, Hannah, Islam, Rakibul, Koza, Darrell, Reyes-Ortega, Felisa, Alba-Molina, David, Nilsson, Per H., Dohlman, Claes H., Mollnes, Tom Eirik, Chodosh, James, Gonzalez-Andrades, Miguel

“…Gelatin based adhesives have been used in the last decades in different biomedical applications due to the excellent biocompatibility, easy processability,…”
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Complement C3b contributes to Escherichia coli -induced platelet aggregation in human whole blood by Landsem, Anne, Emblem, Åse, Lau, Corinna, Christiansen, Dorte, Gerogianni, Alexandra, Karlsen, Bård Ove, Mollnes, Tom Eirik, Nilsson, Per H, Brekke, Ole-Lars

“…Platelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can…”
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Editorial: Current challenges in complement diagnostics by Nilsson, Per H, Skattum, Lillemor, Toonen, Erik J M

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Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies by Ekdahl, Kristina N., Lambris, John D., Elwing, Hans, Ricklin, Daniel, Nilsson, Per H., Teramura, Yuji, Nicholls, Ian A., Nilsson, Bo

“…When an artificial biomaterial (e.g., a stent or implantable pump) is exposed to blood, plasma proteins immediately adhere to the surface, creating a new…”
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Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner by Quach, Huy Quang, Johnson, Christina, Ekholt, Karin, Islam, Rakibul, Mollnes, Tom Eirik, Nilsson, Per H

“…In a recent study, we found an elevated level of interleukin 8 (IL-8) in response to bacterial incubation in thrombin-sufficient human whole blood…”
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In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model by Gerogianni, Alexandra, Bal, Melissa, Mohlin, Camilla, Woodruff, Trent M, Lambris, John D, Mollnes, Tom E, Sjöström, Dick J, Nilsson, Per H

“…Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by…”
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Quartz Crystal Microbalance Platform for SARS-CoV-2 Immuno-Diagnostics by Nilsson, Per H, Al-Majdoub, Mahmoud, Ibrahim, Ahmed, Aseel, Obaidullah, Suriyanarayanan, Subramanian, Andersson, Linnea, Fostock, Samir, Aastrup, Teodor, Tjernberg, Ivar, Rydén, Ingvar, Nicholls, Ian A

“…Rapid and accurate serological analysis of SARS-CoV-2 antibodies is important for assessing immune protection from vaccination or infection of individuals and…”
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The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model by Fageräng, Beatrice, Götz, Maximilian Peter, Cyranka, Leon, Lau, Corinna, Nilsson, Per H, Mollnes, Tom Eirik, Garred, Peter

“…We aimed to elucidate the inflammatory response of Aspergillus fumigatus conidia in a whole-blood model of innate immune activation and to compare it with the…”
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Pitfalls in complement analysis: A systematic literature review of assessing complement activation by Brandwijk, Ricardo J. M. G. E., Michels, Marloes A. H. M., van Rossum, Mara, de Nooijer, Aline H., Nilsson, Per H., de Bruin, Wieke C. C., Toonen, Erik J. M.

“…Background The complement system is an essential component of our innate defense and plays a vital role in the pathogenesis of many diseases. Assessment of…”
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Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses by Islam, Rakibul, Islam, Mohammad Mirazul, Nilsson, Per H., Mohlin, Camilla, Hagen, Kjersti Thorvaldsen, Paschalis, Eleftherios I., Woods, Russell L., Bhowmick, Sabuj Chandra, Dohlman, Claes H., Espevik, Terje, Chodosh, James, Gonzalez-Andrades, Miguel, Mollnes, Tom Eirik

“…Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute…”
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Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice by Huber-Lang, Markus, Barratt-Due, Andreas, Pischke, Søren E, Sandanger, Øystein, Nilsson, Per H, Nunn, Miles A, Denk, Stephanie, Gaus, Wilhelm, Espevik, Terje, Mollnes, Tom E

“…Sepsis and septic shock, caused by an excessive systemic host-inflammatory response, are associated with high morbidity and mortality. The complement system…”
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Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation by Gerogianni, Alexandra, Dimitrov, Jordan D., Zarantonello, Alessandra, Poillerat, Victoria, Chonat, Satheesh, Sandholm, Kerstin, McAdam, Karin E., Ekdahl, Kristina N., Mollnes, Tom E., Mohlin, Camilla, Roumenina, Lubka T., Nilsson, Per H.

“…Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the…”
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Storage of Transfusion Platelet Concentrates Is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor by Andersson, Linnea I, Sjöström, Dick J, Quach, Huy Quang, Hägerström, Kim, Hurler, Lisa, Kajdácsi, Erika, Cervenak, László, Prohászka, Zoltán, Toonen, Erik J M, Mohlin, Camilla, Mollnes, Tom Eirik, Sandgren, Per, Tjernberg, Ivar, Nilsson, Per H

“…Platelet activation and the complement system are mutually dependent. Here, we investigated the effects of storage time on complement activation and platelet…”
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Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE by Gerogianni, Alexandra, Baas, Laura M., Sjöström, Dick J., van de Kar, Nicole C. A. J., Pullen, Marit, van de Peppel, Siem J., Nilsson, Per H., van den Heuvel, Lambertus P.

“…Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI degrades C3b, which inhibits further complement activation…”
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Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating by Nilsson, Per H, Ekdahl, Kristina N, Magnusson, Peetra U, Qu, Hongchang, Iwata, Hiroo, Ricklin, Daniel, Hong, Jaan, Lambris, John D, Nilsson, Bo, Teramura, Yuji

“…Abstract Activation of the thrombotic and complement systems is the main recognition and effector mechanisms in the multiple adverse biological responses…”
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Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1 by Hamad, Osama A, Nilsson, Per H, Wouters, Diana, Lambris, John D, Ekdahl, Kristina N, Nilsson, Bo

“…It has been reported that complement is activated on the surface of activated platelets, despite the presence of multiple regulators of complement activation…”
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The allosteric modulation of complement C5 by knob domain peptides by Macpherson, Alex, Laabei, Maisem, Ahdash, Zainab, Graewert, Melissa A, Birtley, James R, Schulze, Monika-Sarah Ed, Crennell, Susan, Robinson, Sarah A, Holmes, Ben, Oleinikovas, Vladas, Nilsson, Per H, Snowden, James, Ellis, Victoria, Mollnes, Tom Eirik, Deane, Charlotte M, Svergun, Dmitri, Lawson, Alastair Dg, van den Elsen, Jean Mh

“…Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce…”
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Platelets, complement, and contact activation: partners in inflammation and thrombosis by Hamad, Osama A, Bäck, Jennie, Nilsson, Per H, Nilsson, Bo, Ekdahl, Kristina N

“…Platelet activation during thrombotic events is closely associated with complement and contact system activation, which in turn leads to inflammation. Here we…”
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Contribution of chondroitin sulfate A to the binding of complement proteins to activated platelets by Hamad, Osama A, Nilsson, Per H, Lasaosa, Maria, Ricklin, Daniel, Lambris, John D, Nilsson, Bo, Ekdahl, Kristina Nilsson

“…Exposure of chondroitin sulfate A (CS-A) on the surface of activated platelets is well established. The aim of the present study was to investigate to what…”
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