Legg-Calve-Perthes disease and risks for cardiovascular diseases and blood diseases

We hypothesized that patients with Legg-Calvé-Perthes disease (LCPD) might have higher risks of cardiovascular and blood diseases. A total of 3141 patients, 2 to 15 years of age, with LCPD diagnosed between 1965 and 2005 were identified with the Swedish Inpatient Register. A total of 15 595 individu...

Full description

Saved in:

Bibliographic Details
Published in:	Pediatrics (Evanston) Vol. 125; no. 6; pp. e1308 - e1315
Main Authors:	Hailer, Yasmin D, Montgomery, Scott M, Ekbom, Anders, Nilsson, Olof S, Bahmanyar, Shahram
Format:	Journal Article
Language:	English
Published:	United States American Academy of Pediatrics 01-06-2010
Subjects:	Adolescent Blood diseases Cardiovascular disease Cardiovascular Diseases - epidemiology Child Child, Preschool Children & youth coagulation Comparative analysis Female Femur - blood supply Hematologic Diseases - epidemiology Hip joint Humans hypertension Hypertension - epidemiology ischemic heart disease Kirurgi Kirurgisk forskning Legg-Calve-Perthes disease Legg-Calve-Perthes Disease - epidemiology Legg-Calve-Perthes Disease - physiopathology Male MEDICIN Medicin och hälsovetenskap MEDICINE Myocardial Ischemia - epidemiology Orthopaedics Ortopedi Pathogenesis Pediatrics Proportional Hazards Models Regional Blood Flow Regression analysis Risk factors Socioeconomic Factors Surgery Surgical research
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We hypothesized that patients with Legg-Calvé-Perthes disease (LCPD) might have higher risks of cardiovascular and blood diseases. A total of 3141 patients, 2 to 15 years of age, with LCPD diagnosed between 1965 and 2005 were identified with the Swedish Inpatient Register. A total of 15 595 individuals without LCPD were selected randomly from among the Swedish general population, with matching according to year of birth, age, gender, and region of residence. Cox proportional-hazard regression analyses, with adjustment for socioeconomic index, were used to estimate relative risks. The patients also were compared with their same-gender siblings. Patients with LCPD had a hazard ratio (HR) of 1.70 (95% confidence interval [CI]: 1.39-2.09) for cardiovascular diseases, compared with individuals without LCPD. The point estimate was slightly higher among subjects >30 years of age at the follow-up (HR: 2.10 [95% CI: 1.52-2.91]). There were statistically significantly higher risks for blood diseases, including anemias and coagulation defects (HR: 1.41 [95% CI: 1.07-1.86]), which were more pronounced among subjects >30 years of age at the follow-up (HR: 2.70 [95% CI: 1.50-4.84]). Patients also had statistically significantly higher risks of hypertensive disease (HR: 2.97 [95% CI: 1.87-4.72]) and nutritional anemia (HR: 2.92 [95% CI: 1.58-5.40]). Analyses using siblings as the comparison group showed consistent results for cardiovascular diseases. The results are consistent with the hypothesis that an insufficient blood supply to the femoral head, attributable to vascular pathologic conditions, is involved in the pathogenesis of LCPD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0031-4005 1098-4275 1098-4275
DOI:	10.1542/peds.2009-2935