Search Results - "Nilsson, Lars N. G."

Glial activation and inflammation along the Alzheimer's disease continuum by Nordengen, Kaja, Kirsebom, Bjørn-Eivind, Henjum, Kristi, Selnes, Per, Gísladóttir, Berglind, Wettergreen, Marianne, Torsetnes, Silje Bøen, Grøntvedt, Gøril Rolfseng, Waterloo, Knut K, Aarsland, Dag, Nilsson, Lars N G, Fladby, Tormod

“…Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid…”
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Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease by Henjum, Kristi, Almdahl, Ina S, Årskog, Vibeke, Minthon, Lennart, Hansson, Oskar, Fladby, Tormod, Nilsson, Lars N G

“…Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor…”
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Sensitive ELISA detection of amyloid-β protofibrils in biological samples by Englund, Hillevi, Sehlin, Dag, Johansson, Ann-Sofi, Nilsson, Lars N.G, Gellerfors, Pär, Paulie, Staffan, Lannfelt, Lars, Pettersson, Frida Ekholm

“…Amyloid-β (Aβ) protofibrils are known intermediates of the in vitro Aβ aggregation process and the protofibrillogenic Arctic mutation (APPE693G) provides…”
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Elevated mRNA-levels of gonadotropin-releasing hormone and its receptor in plaque-bearing Alzheimer's disease transgenic mice by Nuruddin, Syed, Syverstad, Gry Helen Enger, Lillehaug, Sveinung, Leergaard, Trygve B, Nilsson, Lars N G, Ropstad, Erik, Krogenæs, Anette, Haraldsen, Ira Ronit Hebold, Torp, Reidun

“…Research on Alzheimer's disease (AD) has indicated an association between hormones of the hypothalamic-pituitary-gonadal (HPG) axis and cognitive senescence,…”
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Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice by Åbjørsbråten, Knut Sindre, Skaaraas, Gry HE Syverstad, Cunen, Céline, Bjørnstad, Daniel M, Binder, Kristin M Gullestad, Bojarskaite, Laura, Jensen, Vidar, Nilsson, Lars NG, Rao, Shreyas B, Tang, Wannan, Hermansen, Gudmund Horn, Nagelhus, Erlend A, Ottersen, Ole Petter, Torp, Reidun, Enger, Rune

“…Increased astrocytic Ca 2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced…”
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Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease by Zielinski, Mara, Peralta Reyes, Fernanda S., Gremer, Lothar, Schemmert, Sarah, Frieg, Benedikt, Schäfer, Luisa U., Willuweit, Antje, Donner, Lili, Elvers, Margitta, Nilsson, Lars N. G., Syvänen, Stina, Sehlin, Dag, Ingelsson, Martin, Willbold, Dieter, Schröder, Gunnar F.

“…The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for the preclinical assessment of new treatment strategies for…”
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Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease by Kamali-Moghaddam, Masood, Pettersson, Frida Ekholm, Wu, Di, Englund, Hillevi, Darmanis, Spyros, Lord, Anna, Tavoosidana, Gholamreza, Sehlin, Dag, Gustafsdottir, Sigrun, Nilsson, Lars N G, Lannfelt, Lars, Landegren, Ulf

“…Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides…”
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Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study by Codita, Alina, Gumucio, Astrid, Lannfelt, Lars, Gellerfors, Pär, Winblad, Bengt, Mohammed, Abdul H., Nilsson, Lars N.G.

“…Transgenic animals expressing mutant human amyloid precursor protein (APP) are used as models for Alzheimer disease (AD). Ideally, behavioral tests improve the…”
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The Arctic Alzheimer mutation favors intracellular amyloid‐β production by making amyloid precursor protein less available to α‐secretase by Sahlin, Charlotte, Lord, Anna, Magnusson, Kristina, Englund, Hillevi, Almeida, Claudia G., Greengard, Paul, Nyberg, Fred, Gouras, Gunnar K., Lannfelt, Lars, Nilsson, Lars N.G.

“…Mutations within the amyloid‐β (Aβ) domain of the amyloid precursor protein (APP) typically generate hemorrhagic strokes and vascular amyloid angiopathy. In…”
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Amyloid-β oligomers are inefficiently measured by enzyme-linked immunosorbent assay by Stenh, Charlotte, Englund, Hillevi, Lord, Anna, Johansson, Ann-Sofi, Almeida, Claudia G., Gellerfors, Pär, Greengard, Paul, Gouras, Gunnar K., Lannfelt, Lars, Nilsson, Lars N. G.

“…Amyloid‐β (Aβ) peptide levels are widely measured by enzyme‐linked immunosorbent assay (ELISA) in Alzheimer's disease research. Here, we show that…”
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CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau by Henjum, Kristi, Quist-Paulsen, Else, Zetterberg, Henrik, Blennow, Kaj, Nilsson, Lars N G, Watne, Leiv Otto

“…Delirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor…”
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Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice by Jendresen, Charlotte B., Cui, Hao, Zhang, Xiao, Vlodavsky, Israel, Nilsson, Lars N.G., Li, Jin-Ping

“…Heparan sulfate (HS) and HS proteoglycans (HSPGs) colocalize with amyloid-β (Aβ) deposits in Alzheimer disease brain and in Aβ precursor protein (AβPP)…”
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The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide by Ramberg, Veronica, Tracy, Linda M, Samuelsson, Malin, Nilsson, Lars N G, Iverfeldt, Kerstin

“…The transcription factors CCAAT/enhancer binding proteins (C/EBP) α, β and δ have been shown to be expressed in brain and to be involved in regulation of…”
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Contrast Enhanced Magnetic Resonance Imaging of Amyloid-β Plaques in a Murine Alzheimer's Disease Model by Sulheim, Einar, WiderØe, Marius, Bäck, Marcus, Nilsson, K Peter R, Hammarström, Per, Nilsson, Lars N G, Davies, Catharina de Lange, Åslund, Andreas K O

“…Early detection of amyloid-β (Aβ) aggregates is a critical step to improve the treatment of Alzheimer's disease (AD) because neuronal damage by the Aβ…”
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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion by Pagnon de la Vega, María, Syvänen, Stina, Giedraitis, Vilmantas, Hooley, Monique, Konstantinidis, Evangelos, Meier, Silvio R, Rokka, Johanna, Eriksson, Jonas, Aguilar, Ximena, Spires-Jones, Tara L, Lannfelt, Lars, Nilsson, Lars N G, Erlandsson, Anna, Hultqvist, Greta, Ingelsson, Martin, Sehlin, Dag

“…Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer's disease (AD). Different amyloid precursor protein (APP) mutations cause…”
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Imaging Distinct Conformational States of Amyloid-β Fibrils in Alzheimer’s Disease Using Novel Luminescent Probes by Nilsson, K. Peter R, Åslund, Andreas, Berg, Ina, Nyström, Sofie, Konradsson, Peter, Herland, Anna, Inganäs, Olle, Stabo-Eeg, Frantz, Lindgren, Mikael, Westermark, Gunilla T, Lannfelt, Lars, Nilsson, Lars N. G, Hammarström, Per

“…Using luminescent conjugated polyelectrolyte probes (LCPs), we demonstrate the possibility to distinguish amyloid-β 1–42 peptide (Aβ1–42) fibril conformations,…”
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Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain by Zhang, Xiao, Wang, Bo, O’Callaghan, Paul, Hjertström, Elina, Jia, Juan, Gong, Feng, Zcharia, Eyal, Nilsson, Lars N. G., Lannfelt, Lars, Vlodavsky, Israel, Lindahl, Ulf, Li, Jin-Ping

“…Neuroinflammation is typically observed in neurodegenerative diseases such as Alzheimer’s disease, as well as after traumatic injury and pathogen infection…”
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Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease by Lord, Anna, Philipson, Ola, Klingstedt, Therése, Westermark, Gunilla, Hammarström, Per, Nilsson, K. Peter R, Nilsson, Lars N.G

“…Studies of familial Alzheimer's disease suggest that misfolding and aggregation of amyloid-β (Aβ) peptides initiate the pathogenesis. The Arctic mutation of Aβ…”
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An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease by Lord, Anna, Gumucio, Astrid, Englund, Hillevi, Sehlin, Dag, Sundquist, Valentina Screpanti, Söderberg, Linda, Möller, Christer, Gellerfors, Pär, Lannfelt, Lars, Pettersson, Frida Ekholm, Nilsson, Lars N.G

“…Abstract Human genetics link Alzheimer's disease pathogenesis to excessive accumulation of amyloid-β (Aβ) in brain, but the symptoms do not correlate with…”
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Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice by Lord, Anna, Englund, Hillevi, Söderberg, Linda, Tucker, Stina, Clausen, Fredrik, Hillered, Lars, Gordon, Marcia, Morgan, Dave, Lannfelt, Lars, Pettersson, Frida E, Nilsson, Lars N.G

“…Oligomeric assemblies of amyloid-β (Aβ) are suggested to be central in the pathogenesis of Alzheimer's disease because levels of soluble Aβ correlate much…”
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