Search Results - "Nilsson, K. K."

Amyloid fibril polymorphism: a challenge for molecular imaging and therapy by Fändrich, M., Nyström, S., Nilsson, K. P. R., Böckmann, A., LeVine, H., Hammarström, P.

“…The accumulation of misfolded proteins (MPs), both unique and common, for different diseases is central for many chronic degenerative diseases. In certain…”
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ApoE facilitates the microglial response to amyloid plaque pathology by Ulrich, Jason D, Ulland, Tyler K, Mahan, Thomas E, Nyström, Sofie, Nilsson, K Peter, Song, Wilbur M, Zhou, Yingyue, Reinartz, Mariska, Choi, Seulah, Jiang, Hong, Stewart, Floy R, Anderson, Elise, Wang, Yaming, Colonna, Marco, Holtzman, David M

“…One of the hallmarks of Alzheimer's disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ)…”
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Mass-metallicity relation from z = 5 to the present: evidence for a transition in the mode of galaxy growth at z = 2.6 due to the end of sustained primordial gas infall by Møller, P., Fynbo, J. P. U., Ledoux, C., Nilsson, K. K.

“…We analyse the redshift evolution of the mass-metallicity relation in a sample of 110 Damped Lyman α absorbers (DLAs) spanning the redshift range z = 0.11-5.06…”
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Specific Imaging of Intracellular Lipid Droplets Using a Benzothiadiazole Derivative with Solvatochromic Properties by Appelqvist, Hanna, Stranius, Kati, Börjesson, Karl, Nilsson, K. Peter. R, Dyrager, Christine

“…Altered lipid metabolism and extensive lipid storage in cells have been associated with various medical disorders, including cancer. The development of…”
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Cellulose from the green macroalgae Ulva lactuca: isolation, characterization, optotracing, and production of cellulose nanofibrils by Wahlström, Niklas, Edlund, Ulrica, Pavia, Henrik, Toth, Gunilla, Jaworski, Aleksander, Pell, Andrew J., Choong, Ferdinand X., Shirani, Hamid, Nilsson, K. Peter R., Richter-Dahlfors, Agneta

“…We report (1) successful extraction and characterization of cellulose from northern hemisphere green macroalgae Ulva lactuca ( Ulva fenestrata ) collected…”
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Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila by Caesar, Ina, Jonson, Maria, Nilsson, K Peter R, Thor, Stefan, Hammarström, Per

“…The pathology of Alzheimer's disease (AD) is characterized by the presence of extracellular deposits of misfolded and aggregated amyloid-β (Aβ) peptide and…”
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Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy by Shahnawaz, Mohammad, Mukherjee, Abhisek, Pritzkow, Sandra, Mendez, Nicolas, Rabadia, Prakruti, Liu, Xiangan, Hu, Bo, Schmeichel, Ann, Singer, Wolfgang, Wu, Gang, Tsai, Ah-Lim, Shirani, Hamid, Nilsson, K. Peter R., Low, Phillip A., Soto, Claudio

“…Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of α-synuclein, including Parkinson’s disease,…”
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OJ287: Deciphering the “Rosetta stone of blazars★” by Britzen, S, Fendt, C, Witzel, G, Qian, S -J, Pashchenko, I N, Kurtanidze, O, Zajacek, M, Martinez, G, Karas, V, Aller, M, Aller, H, Eckart, A, Nilsson, K, Arévalo, P, Cuadra, J, Subroweit, M, Witzel, A

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Thiophene‐Based Optical Ligands That Selectively Detect Aβ Pathology in Alzheimer's Disease by Klingstedt, Therése, Shirani, Hamid, Ghetti, Bernardino, Vidal, Ruben, R. Nilsson, K. Peter

“…In several neurodegenerative diseases, the presence of aggregates of specific proteins in the brain is a significant pathological hallmark; thus, developing…”
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Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease by Rasmussen, Jay, Mahler, Jasmin, Beschorner, Natalie, Kaeser, Stephan A., Häsler, Lisa M., Baumann, Frank, Nyström, Sofie, Portelius, Erik, Blennow, Kaj, Lashley, Tammaryn, Fox, Nick C., Sepulveda-Falla, Diego, Glatzel, Markus, Oblak, Adrian L., Ghetti, Bernardino, Nilsson, K. Peter R., Hammarström, Per, Staufenbiel, Matthias, Walker, Lary C., Jucker, Mathias

“…The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes…”
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Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals Aβ Aggregation Dependent Anionic Lipid Accumulations and Metabolism by Michno, Wojciech, Kaya, Ibrahim, Nyström, Sofie, Guerard, Laurent, Nilsson, K. Peter R, Hammarström, Per, Blennow, Kaj, Zetterberg, Henrik, Hanrieder, Jörg

“…Amyloid plaque formation constitutes one of the main pathological hallmarks of Alzheimer’s disease (AD) and is suggested to be a critical factor driving…”
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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules by Maji, Samir K, Perrin, Marilyn H, Sawaya, Michael R, Jessberger, Sebastian, Vadodaria, Krishna, Rissman, Robert A, Singru, Praful S, Nilsson, K. Peter R, Simon, Rozalyn, Schubert, David, Eisenberg, David, Rivier, Jean, Sawchenko, Paul, Vale, Wylie, Riek, Roland

“…Amyloids are highly organized cross-β-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease…”
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Axonal and myelinic pathology in 5xFAD Alzheimer's mouse spinal cord by Chu, Tak-Ho, Cummins, Karen, Sparling, Joseph S, Tsutsui, Shigeki, Brideau, Craig, Nilsson, K Peter R, Joseph, Jeffrey T, Stys, Peter K

“…As an extension of the brain, the spinal cord has unique properties which could allow us to gain a better understanding of CNS pathology. The brain and cord…”
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Handgrip strength reference intervals in Swedish, young, healthy adults: The LBA study by Pettersson-Pablo, Paul, Nilsson, Torbjörn K., Hurtig-Wennlöf, Anita

“…•Handgrip strength may differ strongly between populations•Reference intervals are best established locally•Sex, height, and fat-free mass are the main…”
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Precisely Defined Conjugated Oligoelectrolytes for Biosensing and Therapeutics by Wang, Bing, Queenan, Bridget N., Wang, Shu, Nilsson, K. Peter R., Bazan, Guillermo C.

“…Conjugated oligoelectrolytes (COEs) are a relatively new class of synthetic organic molecules with, as of yet, untapped potential for use in organic…”
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Complete skin clearance and Psoriasis Area and Severity Index response rates in clinical practice: predictors, health‐related quality of life improvements and implications for treatment goals by Norlin, J.M., Nilsson, K., Persson, U., Schmitt‐Egenolf, M.

“…Summary Background Psoriasis Area and Severity Index (PASI) 90 is suggested to be the new standard endpoint for randomized controlled trials of biologics for…”
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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates by Shirani, Hamid, Linares, Mathieu, Sigurdson, Christina J., Lindgren, Mikael, Norman, Patrick, Nilsson, K. Peter R.

“…By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene‐based…”
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Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease by Liu, He, Kim, Chae, Haldiman, Tracy, Sigurdson, Christina J., Nyström, Sofie, Nilsson, K. Peter R., Cohen, Mark L., Wisniewski, Thomas, Hammarström, Per, Safar, Jiri G.

“…Amyloid beta (Aβ) deposition in the neocortex is a major hallmark of Alzheimer's disease (AD), but the extent of deposition does not readily explain phenotypic…”
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Deciphering the Electronic Transitions of Thiophene‐Based Donor‐Acceptor‐Donor Pentameric Ligands Utilized for Multimodal Fluorescence Microscopy of Protein Aggregates by Gustafsson, Camilla, Shirani, Hamid, Leira, Petter, Rehn, Dirk R., Linares, Mathieu, Nilsson, K. Peter R., Norman, Patrick, Lindgren, Mikael

“…Anionic pentameric thiophene acetates can be used for fluorescence detection and diagnosis of protein amyloid aggregates. Replacing the central thiophene unit…”
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The orphan receptor GPR55 is a novel cannabinoid receptor by Ryberg, E, Larsson, N, Sjögren, S, Hjorth, S, Hermansson, N‐O, Leonova, J, Elebring, T, Nilsson, K, Drmota, T, Greasley, P J

“…Background: The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors. Work by a number of groups in…”
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