Search Results - "Nikula, Tuomo K"

Alpha-Emitting Bismuth Cyclohexylbenzyl DTPA Constructs of Recombinant Humanized Anti-CD33 Antibodies: Pharmacokinetics, Bioactivity, Toxicity and Chemistry by Nikula, Tuomo K, McDevitt, Michael R, Finn, Ronald D, Wu, Chuanchu, Kozak, Robert W, Garmestani, Kayhan, Brechbiel, M.W, Curcio, Michael J, Pippin, C. Greg, Tiffany-Jones, L, Geerlings, Maurits W., Sr, Apostolidis, Christos, Molinet, Roger, Geerlings, Maurits W., Jr, Gansow, Otto A, Scheinberg, David A

“…The alpha-particle-emitting radionuclides have several physical characteristics that make them attractive candidates for radioimmunotherapy: (a) high linear…”
Get full text

Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death by Seidl, Christof, Schröck, Hedwig, Seidenschwang, Sabine, Beck, Roswitha, Schmid, Ernst, Abend, Michael, Becker, Karl-Friedrich, Apostolidis, Christos, Nikula, Tuomo K, Kremmer, Elisabeth, Schwaiger, Markus, Senekowitsch-Schmidtke, Reingard

“…Radioimmunotherapy with alpha-particle-emitting nuclides, such as 213Bi, is a promising concept for the elimination of small tumour nodules or single…”
Get full text

In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage by VANDENBULCKE, Katia, DE VOS, Filip, LAHORTE, Christophe, THIERENS, Hubert, DIERCKX, Rudi A, SLEGERS, Guido, OFFNER, Fritz, PHILIPPE, Jan, APOSTOLIDIS, Christos, MOLINET, Roger, NIKULA, Tuomo K, BACHER, Klaus, DE GELDER, Virginie, VRAL, Anne

“…External source radiotherapy and beta radioimmunotherapy (RIT) are effective treatments for lymphoid malignancies. The development of RIT with alpha emitters…”
Get full text

Radiolabeled anti-CD33 monoclonal antibody M195 for myeloid leukemias by Jurcic, J G, Caron, P C, Nikula, T K, Papadopoulos, E B, Finn, R D, Gansow, O A, Miller, Jr, W H, Geerlings, M W, Warrell, Jr, R P, Larson, S M

“…M195, a mouse monoclonal antibody reactive with the early myeloid antigen CD33, has been shown to target leukemia cells in patients and to reduce large…”
Get full text

Impact of the high tyrosine fraction in complementarity determining regions: measured and predicted effects of radioiodination on IgG immunoreactivity by Nikula, Tuomo K., Bocchia, Monica, Curcio, Michael J., Sgouros, George, Ma, Yan, Finn, Ronald D., Scheinberg, David A.

“…Although iodine-131 is the most widely used radionuclide for radioimmunotherapy, direct radiolabeling methods yield decreased immunoreactivity of the antibody…”
Get full text

Highly specific tumor binding of a 213Bi-labeled monoclonal antibody against mutant E-cadherin suggests its usefulness for locoregional α-radioimmunotherapy of diffuse-type gastric cancer by SENEKOWITSCH-SCHMIDTKE, Reingard, SCHUHMACHER, Christoph, KREMMER, Elisabeth, FISCHER, Kathrin, SCHWAIGER, Markus, BECKER, Karl-Friedrich, NIKULA, Tuomo K, SEIDL, Christof, BECKER, Ingrid, MIEDERER, Matthias, APOSTOLIDIS, Christos, ADAM, Christoph, HUBER, Roswitha

“…A monoclonal antibody (E-cadherin delta 9-1) directed against a characteristic E-cadherin mutation (in-frame deletion of exon 9), found in diffuse-type gastric…”
Get full text

A rapid, single vessel method for preparation of clinical grade ligand conjugated monoclonal antibodies by Nikula, Tuomo K., Curcio, Michael J., Brechbiel, Martin W., Gansow, Otto A., Finn, Ronald D., Scheinberg, David A.

“…A rapid, single vessel method for the preparation of clinical grade chelate conjugated monoclonal antibodies has been developed. By use of an Amicon…”
Get full text

Expression profile of vascular cell adhesion molecule-1 (CD106) in inflammatory foci using rhenium-188 labelled monoclonal antibody in mice by Kairemo, K J, Strömberg, S, Nikula, T K, Karonen, S L

“…Rhenium (Re)-188 is a generator (W-188/Re-188) produced high energy beta-emitter suitable for radionuclide therapy (T1/2 is 16.9 hrs and Emax 2.1 MeV (range 11…”
Get more information