Search Results - "Nikula, T"

Alpha-Emitting Bismuth Cyclohexylbenzyl DTPA Constructs of Recombinant Humanized Anti-CD33 Antibodies: Pharmacokinetics, Bioactivity, Toxicity and Chemistry by Nikula, Tuomo K, McDevitt, Michael R, Finn, Ronald D, Wu, Chuanchu, Kozak, Robert W, Garmestani, Kayhan, Brechbiel, M.W, Curcio, Michael J, Pippin, C. Greg, Tiffany-Jones, L, Geerlings, Maurits W., Sr, Apostolidis, Christos, Molinet, Roger, Geerlings, Maurits W., Jr, Gansow, Otto A, Scheinberg, David A

“…The alpha-particle-emitting radionuclides have several physical characteristics that make them attractive candidates for radioimmunotherapy: (a) high linear…”
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Lymph flow dynamics in exercising human skeletal muscle as detected by scintography by Havas, Eino, Parviainen, Tapani, Vuorela, Juha, Toivanen, Jarmo, Nikula, Tuomo, Vihko, Veikko

“…1. The effects of dynamic and isometric muscle contractions on the lymph flow dynamics in human skeletal muscle were studied with a scintographic method. 2…”
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A human ImmunoChip cDNA microarray provides a comprehensive tool to study immune responses by Nikula, T., West, A., Katajamaa, M., Lönnberg, T., Sara, R., Aittokallio, T., Nevalainen, O.S., Lahesmaa, R.

“…DNA microarray technology has developed rapidly in recent years and has become an essential tool, providing novel approaches to biomedical research. In this…”
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“You Can Stand Under My Umbrella”: Immersion, CLIL and Bilingual Education. A Response to Cenoz, Genesee & Gorter (2013) by Dalton-Puffer, Christiane, Llinares, Ana, Lorenzo, Francisco, Nikula, Tarja

“…Classrooms the world over are full of people who, for different reasons, are learning additional languages and/or are studying through languages that are not…”
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A rapid, single vessel method for preparation of clinical grade ligand conjugated monoclonal antibodies by Nikula, Tuomo K., Curcio, Michael J., Brechbiel, Martin W., Gansow, Otto A., Finn, Ronald D., Scheinberg, David A.

“…A rapid, single vessel method for the preparation of clinical grade chelate conjugated monoclonal antibodies has been developed. By use of an Amicon…”
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Radiolabeled anti-CD33 monoclonal antibody M195 for myeloid leukemias by Jurcic, J G, Caron, P C, Nikula, T K, Papadopoulos, E B, Finn, R D, Gansow, O A, Miller, Jr, W H, Geerlings, M W, Warrell, Jr, R P, Larson, S M

“…M195, a mouse monoclonal antibody reactive with the early myeloid antigen CD33, has been shown to target leukemia cells in patients and to reduce large…”
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Impact of the high tyrosine fraction in complementarity determining regions: measured and predicted effects of radioiodination on IgG immunoreactivity by Nikula, Tuomo K., Bocchia, Monica, Curcio, Michael J., Sgouros, George, Ma, Yan, Finn, Ronald D., Scheinberg, David A.

“…Although iodine-131 is the most widely used radionuclide for radioimmunotherapy, direct radiolabeling methods yield decreased immunoreactivity of the antibody…”
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Differential Expression of IFN Regulatory Factor 4 Gene in Human Monocyte-Derived Dendritic Cells and Macrophages by Lehtonen, Anne, Veckman, Ville, Nikula, Tuomas, Lahesmaa, Riitta, Kinnunen, Leena, Matikainen, Sampsa, Julkunen, Ilkka

“…In vitro human monocyte differentiation to macrophages or dendritic cells (DCs) is driven by GM-CSF or GM-CSF and IL-4, respectively. IFN regulatory factors…”
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Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G by Airas, Laura, Nikula, Tuomas, Huang, Yu-Hwa, Lahesmaa, Riitta, Wiendl, Heinz

“…Abstract We used microarray analysis to obtain insights into the immuno-regulatory mechanisms controlling pregnancy-associated MS disease activity. We studied…”
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Accumulation of 99mTc-low-density lipoprotein in human malignant glioma by LEPPÄLÄ, J, KALLIO, M, KAHL, S, FÄRKKILÄ, M, NIKULA, T, NIKKINEN, P, LIEWENDAHL, K, JÄÄSKELÄINEN, J, SAVOLAINEN, S, GYLLING, H, HILTUNEN, J, CALLAWAY, J

“…Low-density lipoprotein (LDL) uptake in gliomas was studied to find out if LDL has potential as a drug carrier of boron, especially for boron neutron capture…”
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IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training by Mero, Antti, Kahkonen, Jonne, Nykanen, Tarja, Parviainen, Tapani, Jokinen, Ilmari, Takala, Timo, Nikula, Tuomo, Rasi, Simo, Leppaluoto, Juhani

“…Departments of 1  Biology of Physical Activity and 3  Biological and Environmental Science, University of Jyväskylä, and 2  Clinical Physiology, Central…”
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Expression profile of vascular cell adhesion molecule-1 (CD106) in inflammatory foci using rhenium-188 labelled monoclonal antibody in mice by Kairemo, K J, Strömberg, S, Nikula, T K, Karonen, S L

“…Rhenium (Re)-188 is a generator (W-188/Re-188) produced high energy beta-emitter suitable for radionuclide therapy (T1/2 is 16.9 hrs and Emax 2.1 MeV (range 11…”
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Up‐Regulation of Host Cell Genes during Interferon‐γ-Induced Persistent Chlamydia pneumoniae Infection in HL Cells by Mannonen, Laura, Nikula, Tuomas, Haveri, Anu, Reinikainen, Arja, Vuola, Jenni M., Lahesmaa, Riitta, Puolakkainen, Mirja

“…As a step toward understanding the role played by host gene expression in the development and pathogenesis of persistent Chlamydia pneumoniae infection,…”
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In Vivo Detection of Vascular Adhesion Protein-1 in Experimental Inflammation by Jaakkola, Kimmo, Nikula, Tuomo, Holopainen, Riikka, Vähäsilta, Tommi, Matikainen, Marja-Terttu, Laukkanen, Marja-Leena, Huupponen, Risto, Halkola, Lauri, Nieminen, Lauri, Hiltunen, Jukka, Parviainen, Sakari, Clark, Michael R., Knuuti, Juhani, Savunen, Timo, Kääpä, Pekka, Voipio-Pulkki, Liisa Maria, Jalkanen, Sirpa

“…Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial glycoprotein which mediates leukocyte-endothelial cell interactions. To study the…”
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Computational strategies for analyzing data in gene expression microarray experiments by Aittokallio, Tero, Kurki, Markus, Nevalainen, Olli, Nikula, Tuomas, West, Anne, Lahesmaa, Riitta

“…Microarray analysis has become a widely used method for generating gene expression data on a genomic scale. Microarrays have been enthusiastically applied in…”
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Comparison of the Radiotoxicity of Two Alpha-Particle-Emitting Immunoconjugates, Terbium-149 and Bismuth-213, Directed against a Tumor-Specific, Exon 9 Deleted (d9) E-Cadherin Adhesion Protein by Miederer, Matthias, Seidl, Christof, Beyer, Gerd-Jürgen, Charlton, David E., Vranjes-Duric, Sanja, Comor, Jozef J., Huber, Roswitha, Nikula, Tuomo, Apostolidis, Christos, Schuhmacher, Christoph, Becker, Karl-Friedrich, Senekowitsch-Schmidtke, Reingard

“…Miederer, M., Seidl, C., Beyer, G-J., Charlton, D. E., Vranjes-Duric, S., Comor, J. J., Huber, R., Nikula, T., Apostolidis, C., Schuhmacher, C., Becker, K-F…”
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Radioimmunotherapy of B-lineage non-Hodgkin's lymphoma using anti-CD19 and anti-CD20 conjugates by Heeger, S. W., Moldenhauer, G., Flynn, J. M., Egerer, G., Nikula, T., Apostolidis, C., Brechbiel, M., Haberkorn, U., Ho, A. D., Haas, R.

“…Abstract only…”
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Radioimmunotherapy of B-lineage non-Hodgkin's lymphoma using anti-CD19 and anti-CD20 conjugates by Heeger, S. W., Moldenhauer, G., Flynn, J. M., Egerer, G., Nikula, T., Apostolidis, C., Brechbiel, M., Haberkorn, U., Ho, A. D., Haas, R.

“…Abstract only…”
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Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging by Kuikka, J T, Baulieu, J L, Hiltunen, J, Halldin, C, Bergström, K A, Farde, L, Emond, P, Chalon, S, Yu, M, Nikula, T, Laitinen, T, Karhu, J, Tupala, E, Hallikainen, T, Kolehmainen, V, Mauclaire, L, Maziere, B, Tiihonen, J, Guilloteau, D

“…The iodine-123 labelled selective ligand N-(3-iodoprop-2E-enyl)-2-beta-carbomethoxy-3beta-(4-methylphenyl) nortropane ([123I]PE2I) was evaluated as a probe for…”
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Comparison of the Radiotoxicity of Two Alpha-Particle-Emitting Immunoconjugates, Terbium-149 and Bismuth-213, Directed against a Tumor-Specific, Exon 9 Deleted (d9) E-Cadherin Adhesion Protein by Miederer, M, Seidl, C, Beyer, G, Charlton, DE, Vranjes-Duric, S, Comor, J J, Huber, R, Nikula, T, Apostolidis, C, Schuhmacher, C, Becker, K, Senekowitsch-Schmidtke, R

“…We investigated the effects of the alpha -particle emitters 149Tb and 213Bi coupled to a tumor-specific antibody targeting the mutated delta 9 E-cadherin (d9…”
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