Search Results - "Nikolaj, Klöcker"

Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors by Schwenk, Jochen, Harmel, Nadine, Zolles, Gerd, Bildl, Wolfgang, Kulik, Akos, Heimrich, Bernd, Chisaka, Osamu, Jonas, Peter, Schulte, Uwe, Fakler, Bernd, Klöcker, Nikolaj

“…Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic…”
Get full text

Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers by Trads, Julie B., Hüll, Katharina, Matsuura, Bryan S., Laprell, Laura, Fehrentz, Timm, Görldt, Nicole, Kozek, Krystian A., Weaver, C. David, Klöcker, Nikolaj, Barber, David M., Trauner, Dirk

“…Photopharmacology relies on ligands that change their pharmacodynamics upon photoisomerization. Many of these ligands are azobenzenes that are…”
Get full text

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment by Marquard, Jan, Otter, Silke, Welters, Alena, Stirban, Alin, Fischer, Annelie, Eglinger, Jan, Herebian, Diran, Kletke, Olaf, Klemen, Maša Skelin, Stožer, Andraž, Wnendt, Stephan, Piemonti, Lorenzo, Köhler, Martin, Ferrer, Jorge, Thorens, Bernard, Schliess, Freimut, Rupnik, Marjan Slak, Heise, Tim, Berggren, Per-Olof, Klöcker, Nikolaj, Meissner, Thomas, Mayatepek, Ertan, Eberhard, Daniel, Kragl, Martin, Lammert, Eckhard

“…NMDA receptors in pancreatic beta cells inhibit glucose-stimulated insulin secretion, and inhibiting these receptors with an over-the-counter medication…”
Get full text

Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction by Haselmann, Holger, Mannara, Francesco, Werner, Christian, Planagumà, Jesús, Miguez-Cabello, Federico, Schmidl, Lars, Grünewald, Benedikt, Petit-Pedrol, Mar, Kirmse, Knut, Classen, Joseph, Demir, Fatih, Klöcker, Nikolaj, Soto, David, Doose, Sören, Dalmau, Josep, Hallermann, Stefan, Geis, Christian

“…AMPA receptors are essential for fast excitatory transmission in the CNS. Autoantibodies to AMPA receptors have been identified in humans with autoimmune…”
Get full text

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes by Schwenk, Jochen, Harmel, Nadine, Brechet, Aline, Zolles, Gerd, Berkefeld, Henrike, Müller, Catrin Swantje, Bildl, Wolfgang, Baehrens, David, Hüber, Björn, Kulik, Akos, Klöcker, Nikolaj, Schulte, Uwe, Fakler, Bernd

“…AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the mammalian brain including fast excitatory neurotransmission,…”
Get full text

Optical control of L-type Ca2+ channels using a diltiazem photoswitch by Fehrentz, Timm, Huber, Florian M. E., Hartrampf, Nina, Bruegmann, Tobias, Frank, James A., Fine, Nicholas H. F., Malan, Daniela, Danzl, Johann G., Tikhonov, Denis B., Sumser, Martin, Sasse, Philipp, Hodson, David J., Zhorov, Boris S., Klöcker, Nikolaj, Trauner, Dirk

“…L-type Ca 2+ channels (LTCCs) play a crucial role in excitation–contraction coupling and release of hormones from secretory cells. They are targets of…”
Get full text

Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias by Jungen, Christiane, Scherschel, Katharina, Eickholt, Christian, Kuklik, Pawel, Klatt, Niklas, Bork, Nadja, Salzbrunn, Tim, Alken, Fares, Angendohr, Stephan, Klene, Christiane, Mester, Janos, Klöcker, Nikolaj, Veldkamp, Marieke W., Schumacher, Udo, Willems, Stephan, Nikolaev, Viacheslav O., Meyer, Christian

“…The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure…”
Get full text

Cardiac ischemia and reperfusion in mice: a comprehensive hemodynamic, electrocardiographic and electrophysiological characterization by Clasen, Lukas, Angendohr, Stephan, Becher, Stefanie, Bartsch, Benedikt, Enkel, Stephan, Meyer, Christian, Kelm, Malte, Makimoto, Hisaki, Klöcker, Nikolaj

“…Malignant ventricular arrhythmias (VA) after acute myocardial infarction remain a major threat. Aim of this study was to characterize the electrophysiological…”
Get full text

Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking by Erlenhardt, Nadine, Kletke, Olaf, Wohlfarth, Franziska, Komadowski, Marlene A., Clasen, Lukas, Makimoto, Hisaki, Rinné, Susanne, Kelm, Malte, Jungen, Christiane, Decher, Niels, Meyer, Christian, Klöcker, Nikolaj

“…The hyperpolarization-activated cation current I f is a key determinant for cardiac pacemaker activity. It is conducted by subunits of the…”
Get full text

A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias by Clasen, Lukas, Eickholt, Christian, Angendohr, Stephan, Jungen, Christiane, Shin, Dong-In, Donner, Birgit, Fürnkranz, Alexander, Kelm, Malte, Klöcker, Nikolaj, Meyer, Christian, Makimoto, Hisaki

“…Electrophysiological studies in mice, the prevailing model organism in the field of basic cardiovascular research, are impeded by the low yield of programmed…”
Get full text

Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein by Oliver, Dominik, David Z. Z. He, Klöcker, Nikolaj, Ludwig, Jost, Schulte, Uwe, Waldegger, Siegfried, Ruppersberg, J. P., Dallos, Peter, Fakler, Bernd

“…Outer hair cells (OHCs) of the mammalian cochlea actively change their cell length in response to changes in membrane potential. This electromotility, thought…”
Get full text

Depletion of the AMPAR reserve pool impairs synaptic plasticity in a model of hepatic encephalopathy by Schroeter, Annett, Wen, Shuping, Mölders, Andrea, Erlenhardt, Nadine, Stein, Valentin, Klöcker, Nikolaj

“…Hepatic encephalopathy (HE) is the most common neuropsychiatric complication of acute or chronic liver failure. Clinical symptoms include cognitive and…”
Get full text

Sex‐specific repolarization heterogeneity in mouse left ventricle: Optical mapping combined with mathematical modeling predict the contribution of specific ionic currents by Moussavi‐Torshizi, S. Erfan, Amin, Ehsan, Klöcker, Nikolaj

“…Ventricular repolarization shows notable sex‐specificity, with female sex being associated with longer QT‐intervals in electrocardiography irrespective of the…”
Get full text

Selective Golgi export of Kir2.1 controls the stoichiometry of functional Kir2.x channel heteromers by Hofherr, Alexis, Fakler, Bernd, Klöcker, Nikolaj

“…Surface expression of ion channels and receptors often depends on intrinsic sequence motifs that control their intracellular transport along the secretory…”
Get full text

Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice by Scherschel, Katharina, Bräuninger, Hanna, Mölders, Andrea, Erlenhardt, Nadine, Amin, Ehsan, Jungen, Christiane, Pape, Ulrike, Lindner, Diana, Chetkovich, Dane M, Klöcker, Nikolaj, Meyer, Christian

“…The tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b/PEX5R) is an interaction partner and auxiliary subunit of hyperpolarization-activated…”
Get full text

Author Correction: Optical control of L-type Ca2+ channels using a diltiazem photoswitch by Fehrentz, Timm, Huber, Florian M. E., Hartrampf, Nina, Bruegmann, Tobias, Frank, James A., Fine, Nicholas H. F., Malan, Daniela, Danzl, Johann G., Tikhonov, Denis B., Sumser, Martin, Sasse, Philipp, Hodson, David J., Zhorov, Boris S., Klöcker, Nikolaj, Trauner, Dirk

“…A Correction to this paper has been published: https://doi.org/10.1038/s41589-021-00744-3…”
Get full text

NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody by Malviya, Manish, Barman, Sumanta, Golombeck, Kristin S., Planagumà, Jesús, Mannara, Francesco, Strutz‐Seebohm, Nathalie, Wrzos, Claudia, Demir, Fatih, Baksmeier, Christine, Steckel, Julia, Falk, Kim Kristin, Gross, Catharina C., Kovac, Stjepana, Bönte, Kathrin, Johnen, Andreas, Wandinger, Klaus‐Peter, Martín‐García, Elena, Becker, Albert J., Elger, Christian E., Klöcker, Nikolaj, Wiendl, Heinz, Meuth, Sven G., Hartung, Hans‐Peter, Seebohm, Guiscard, Leypoldt, Frank, Maldonado, Rafael, Stadelmann, Christine, Dalmau, Josep, Melzer, Nico, Goebels, Norbert

“…Objective Autoimmune encephalitis is most frequently associated with anti‐NMDAR autoantibodies. Their pathogenic relevance has been suggested by passive…”
Get full text

Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes by Lu, Kaihui, Zimmermann, Marcel, Görg, Boris, Bidmon, Hans-Jürgen, Biermann, Barbara, Klöcker, Nikolaj, Häussinger, Dieter, Reichert, Andreas S.

“…Hepatic encephalopathy (HE) is a severe neuropsychiatric syndrome caused by various types of liver failure resulting in hyperammonemia-induced dysfunction of…”
Get full text

The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca2+ entry in platelets by Reusswig, Friedrich, Yilmaz, Münteha, Brechtenkamp, Marius, Krueger, Irena, Metz, Lisa Maria, Klöcker, Nikolaj, Lammert, Eckhard, Elvers, Margitta

“…IntroductionPlatelet activation and thrombus formation is crucial for hemostasis, but also trigger arterial thrombosis. Calcium mobilization plays an important…”
Get full text

Multi-dimensional fluorescence lifetime and FRET measurements by Biskup, Christoph, Zimmer, Thomas, Kelbauskas, Laimonas, Hoffmann, Birgit, Klöcker, Nikolaj, Becker, Wolfgang, Bergmann, Axel, Benndorf, Klaus

“…When and where proteins associate with each other in living cells are key questions in many biological research projects. One way to address these questions is…”
Get full text