Search Results - "Nikolai, Bryan C."

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer by Dasgupta, Subhamoy, Rajapakshe, Kimal, Zhu, Bokai, Nikolai, Bryan C., Yi, Ping, Putluri, Nagireddy, Choi, Jong Min, Jung, Sung Y., Coarfa, Cristian, Westbrook, Thomas F., Zhang, Xiang H.-F., Foulds, Charles E., Tsai, Sophia Y., Tsai, Ming-Jer, O’Malley, Bert W.

“…Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that sustain rapid proliferation and metastasis 1 . However, the…”
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USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells by Padmanabhan, Achuth, Candelaria, Nicholes, Wong, Kwong-Kwok, Nikolai, Bryan C., Lonard, David M., O’Malley, Bert W., Richards, JoAnne S.

“…Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in cells and play important roles in cancer progression. Selective…”
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Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs by Nikolai, Bryan C., Jain, Prashi, Cardenas, David L., York, Brian, Feng, Qin, McKenna, Neil J., Dasgupta, Subhamoy, Lonard, David M., O’Malley, Bert W.

“…A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against…”
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Identification of celastrol as a novel HIV-1 latency reversal agent by an image-based screen by Liu, Hongbing, Hu, Pei-Wen, Dubrulle, Julien, Stossi, Fabio, Nikolai, Bryan C, Mancini, Michael A, Rice, Andrew P

“…Although current antiretroviral therapies (ART) are successful in controlling HIV-1 infection, a stable viral reservoir reactivates when ART is discontinued…”
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HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes by Nikolai, Bryan C, Lanz, Rainer B, York, Brian, Dasgupta, Subhamoy, Mitsiades, Nicholas, Creighton, Chad J, Tsimelzon, Anna, Hilsenbeck, Susan G, Lonard, David M, Smith, Carolyn L, O'Malley, Bert W

“…Approximately 20% of early-stage breast cancers display amplification or overexpression of the ErbB2/HER2 oncogene, conferring poor prognosis and resistance to…”
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Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology by York, Brian, Yu, Chundong, Sagen, Jørn V., Liu, Zhaoliang, Nikolai, Bryan C., Wu, Ray-Chang, Finegold, Milton, Xu, Jianming, O'Malley, Bert W.

“…Here we demonstrate that reprogramming steroid receptor coactivator-3 (SRC-3) function by changing its posttranslational modification (PTM) code drastically…”
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Ablation of Steroid Receptor Coactivator-3 Resembles the Human CACT Metabolic Myopathy by York, Brian, Reineke, Erin L., Sagen, Jørn V., Nikolai, Bryan C., Zhou, Suoling, Louet, Jean-Francois, Chopra, Atul R., Chen, Xian, Reed, Graham, Noebels, Jeffrey, Adesina, Adekunle M., Yu, Hui, Wong, Lee-Jun C., Tsimelzon, Anna, Hilsenbeck, Susan, Stevens, Robert D., Wenner, Brett R., Ilkayeva, Olga, Xu, Jianming, Newgard, Christopher B., O'Malley, Bert W.

“…Oxidation of lipid substrates is essential for survival in fasting and other catabolic conditions, sparing glucose for the brain and other glucose-dependent…”
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HIV Latency Gets a New Histone Mark by Nikolai, Bryan C., Feng, Qin

“…Transcriptional latency of integrated HIV-1 provirus represents a major obstacle to curing HIV. In this issue of Cell Host & Microbe, Boehm et al. (2017)…”
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Crosstalk between histone modifications indicates that inhibition of arginine methyltransferase CARM1 activity reverses HIV latency by Zhang, Zheng, Nikolai, Bryan C, Gates, Leah A, Jung, Sung Yun, Siwak, Edward B, He, Bin, Rice, Andrew P, O'Malley, Bert W, Feng, Qin

“…In eukaryotic cells, the gene expression status is strictly controlled by epigenetic modifications on chromatin. The repressive status of chromatin largely…”
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Proteomic Profiling of a Primary CD4 + T Cell Model of HIV-1 Latency Identifies Proteins Whose Differential Expression Correlates with Reactivation of Latent HIV-1 by Saha, Jamaluddin Md, Liu, Hongbing, Hu, Pei-Wen, Nikolai, Bryan C, Wu, Hulin, Miao, Hongyu, Rice, Andrew P

“…The latent HIV-1 reservoir of memory CD4 T cells that persists during combination antiviral therapy prevents a cure of infection. Insight into mechanisms of…”
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Abstract 2579: Identifying pathways that regulate the turnover of gain-of-function p53 mutant proteins in ovarian cancer cells by Padmanabhan, Achuth, Candelaria, Nicholes, Wong, Kwong-Kwok, Nikolai, Bryan C., Lonard, David, O'Malley, Bert W., Richards, JoAnne S.

“…Ovarian cancer is the fifth leading cause for cancer-associated deaths among women in the US. High-grade serous ovarian carcinoma is the most common…”
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Abstract 3072: HER2 signaling affects SRC-3 phosphorylation and gene regulatory potential within the cistrome by Nikolai, Bryan C., Smith, Carolyn L., O'Malley, Bert W.

“…Steroid Receptor Coactivator-3 (SRC-3/AIB1) is a potent transcriptional coregulator for nuclear receptors and other transcription factors and is often…”
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