Search Results - "Nikodem, V M"

Early postnatal isolation reduces dopamine levels, elevates dopamine turnover and specifically disrupts prepulse inhibition in Nurr1-null heterozygous mice by Eells, J.B., Misler, J.A., Nikodem, V.M.

“…Sensorimotor gating is a phenomenon that is linked with dopamine neurotransmission in limbic and cortical areas, and disruption of sensorimotor gating has been…”
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Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 ( NGFI-B) in adult rat brain using in situ hybridization by Xiao, Q, Castillo, S.O, Nikodem, V.M

“…Nurr1 and Nur77 ( NGFI-B) are orphan nuclear receptors, belonging to the steroid/thyroid hormone receptor gene superfamily. They have conserved amino acid…”
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Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity by Eells, J.B, Lipska, B.K, Yeung, S.K, Misler, J.A, Nikodem, V.M

“…Nurr1, an orphan nuclear receptor, is essential for the differentiation of the midbrain dopamine (DA) neurons; however, its function in adult midbrain DA…”
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Alternative Splicing Generates Messages Encoding Rat c-erbA Proteins that Do not Bind Thyroid Hormone by Mitsuhashi, Tomoaki, Tennyson, Gregory E., Nikodem, Vera M.

“…The nucleotide and predicted amino acid sequences of two variant cDNAs [rat brain thyroid hormone receptor (rTRα ) vI and vII], isolated from a rat brain cDNA…”
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Molecular basis of thyroid hormone regulation of myelin basic protein gene expression in rodent brain by FARSETTI, A, MITSUHASHI, T, DESVERGNE, B, ROBBINS, J, NIKODEM, V. M

“…Regulation of myelin basic protein (MBP) gene expression by thyroid hormone has been investigated in rodent brain. Quantitation of the 4 major alternatively…”
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A novel heterodimerization partner for thyroid hormone receptor. Peroxisome proliferator-activated receptor by BOGAZZI, F, HUDSON, L. D, NIKODEM, V. M

“…Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors. In this study we have…”
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Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter by FARSETTI, A, DESVERGNE, B, HALLENBECK, P, ROBBINS, J, NIKODEM, V. M

“…In this report we have characterized further the myelin basic protein (MBP) gene thyroid hormone response element (TRE) by functional and binding analysis…”
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H‐2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes by Marks, M.S., Hallenbeck, P.L., Nagata, T., Segars, J.H., Appella, E., Nikodem, V.M., Ozato, K.

“…H‐2RIIBP (RXR beta) is a member of the nuclear hormone receptor superfamily that activates transcription of MHC class I genes in response to retinoic acid…”
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Differential expression of tyrosine hydroxylase in catecholaminergic neurons of neonatal wild-type and nurr1-deficient mice by Baffi, J.S., Palkovits, M., Castillo, S.O., Mezey, È., Nikodem, V.M.

“…The orphan nuclear receptor Nurr1 is a transcription factor that belongs to the steroid/thyroid hormone receptor superfamily and is expressed in many regions…”
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Identification of a thyroid hormone response element in the malic enzyme gene by PETTY, K. J, DESVERGNE, B, MITSUHASHI, T, NIKODEM, V. M

“…We have studied the rat malic enzyme gene as a model for thyroid hormone (triiodothyronine (T3)) regulation of transcription. Our previous studies showed that…”
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Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element by Desvergne, B, Petty, K J, Nikodem, V M

“…We previously showed that the 5'-flanking region of the malic enzyme (ME) gene contains a cis-regulatory element (-281 to -261) that binds thyroid hormone…”
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DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle by Christianson, A.M.K. (DNX Corporation, Princeton, NJ), King, D.L, Hatzivassiliou, E, Casas, J.E, Hallenbeck, P.L, Nikodem, V.M, Mitsialis, S.A, Kafatos, F.C

“…The Drosophila chorion factor 1/ultraspiracle (CF1/USP) transcription factor, a homologue of the retinoid X receptor, is a developmentally important member of…”
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Heterodimerization of Thyroid Hormone (TH) Receptor with H-2RIIBP (RXBβ) Enhances DNA Binding and TH-Dependent Transcriptional Activation by Hallenbeck, Paul L., Marks, Michael S., Lippoldt, Roland E., Ozato, Keiko, Nikodem, Vera M.

“…Steroid/TH receptors mediate transcriptional induction of promoters containing hormone response elements (HREs) through an unclear mechanism that involves…”
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Regulation of Expression of the Alternative mRNAs of the Rat α-Thyroid Hormone Receptor Gene by Mitsuhashi, T, Nikodem, V M

“…The rat α-thyroid hormone receptor gene encodes through alternative splicing at least three protein isoforms with different functions, and three mRNA species…”
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Divergent effects of 9-cis-retinoic acid receptor on positive and negative thyroid hormone receptor-dependent gene expression by HALLENBECK, P. L, PHYILLAIER, M, NIKODEM, V. M

“…The thyroid hormone (TH)-inducible expression of some genes has recently been shown to be enhanced by 9-cis-retinoic acid (9-cis-RA) receptor (RXR). This…”
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Thyroid hormone regulation of malic enzyme synthesis. Dual tissue-specific control by Dozin, B, Magnuson, M A, Nikodem, V M

“…The regulatory mechanism(s) involved in the tissue-specific induction of cytosolic malic enzyme (EC 1.1.1.40) by triiodothyronine (T3) have been investigated…”
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Erythropoietin receptor signalling is required for normal brain development by Yu, Xiaobing, Shacka, John J, Eells, Jeffrey B, Suarez-Quian, Carlos, Przygodzki, Ronald M, Beleslin-Cokic, Bojana, Lin, Chyuan-Sheng, Nikodem, Vera M, Hempstead, Barbara, Flanders, Kathleen C, Costantini, Frank, Noguchi, Constance Tom

“…Erythropoietin, known for its role in erythroid differentiation, has been shown to be neuroprotective during brain ischaemia in adult animal models. Although…”
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The N-terminal region (A/B) of rat thyroid hormone receptors alpha 1, beta 1, but not beta 2 contains a strong thyroid hormone-dependent transactivation function by Tomura, H, Lazar, J, Phyillaier, M, Nikodem, V M

“…In this study we have investigated the role of the N-terminal region of thyroid hormone receptors (TRs) in thyroid hormone (TH)-dependent transactivation of a…”
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Recombinant Thyroid Hormone Receptor and Retinoid X Receptor Stimulate Ligand-Dependent Transcription in vitro by Lee, Insong J., Driggers, Paul H., Medin, Jeffrey A., Nikodem, Vera M., Ozato, Keiko

“…The thyroid hormone and retinoid X receptors form a heterodimer with each other and mediate thyroid hormone (T3)-dependent transcription. Retinoid X receptor,…”
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Organization, Sequence, Chromosomal Localization, and Promoter Identification of the Mouse Orphan Nuclear Receptor Nurr1 Gene by Castillo, Susan O., Xiao, Qianxun, Lyu, Myung S., Kozak, Christine A., Nikodem, Vera M.

“…We have cloned and characterized the organization of the mouse orphan nuclear receptor Nurr1 gene. The Nurr1 gene is approximately 7 kb long, contains eight…”
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