Search Results - "Nikkari, T"

Hematocrit value at early middle age predicts hypertension at late middle age; the Tampere adult population cardiovascular risk study, a 30-year follow-up by Piesanen, Jaakko, Kunnas, Tarja, Nikkari, Seppo T

“…•Hematocrit values of ≥ 45 % at early middle age predicted later hypertension.•Hematocrit ≥ 45 % also predicted later coronary artery disease and…”
Get full text

Contribution of fatty acid transporter (CD36) genetic variant rs1761667 to body mass index, the TAMRISK study by Solakivi, Tiina, Kunnas, Tarja, Nikkari, Seppo T.

“…Abstract Background. Human fatty acid transporter CD36 gene variations have previously been associated with fat preferences and obesity. These variations could…”
Get full text

Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study, a 28-year follow-up by Kunnas, T, Solakivi, T, Huuskonen, K, Kalela, A, Renko, J, Nikkari, Seppo T

“…Abstract Objective To evaluate whether hematocrit (HCT) is associated with coronary heart disease (CHD) mortality in men over 55 years of age in Finland…”
Get full text

Family history of hypertension enhances age-dependent rise in blood pressure, a 15-year follow-up, the Tampere adult population cardiovascular risk study by Kunnas, Tarja, Nikkari, Seppo T.

“…A family history (FH) of hypertension is known to predispose to high blood pressure. We wanted to study whether it associates with blood pressure and…”
Get full text

Overexpression of Tissue Inhibitor of Matrix Metalloproteinase-1 Inhibits Vascular Smooth Muscle Cell Functions In Vitro and In Vivo by Forough, Reza, Koyama, Noriyuki, Hasenstab, David, Lea, Holly, Clowes, Monika, Nikkari, T, Clowes, Alexander W

“…Arterial smooth muscle cells (SMCs) are in a quiescent growth state under normal physiological conditions, but they can be stimulated to proliferate and…”
Get full text

The gene variant for desmin rs1058261 may protect against combined cancer and cardiovascular death, the Tampere adult population cardiovascular risk study by Piesanen, Jaakko, Kunnas, Tarja, Nikkari, Seppo T

“…Desmin-containing intermediate filaments are a part of muscle cytoskeleton. We have previously reported that the wild-type cytosine/cytosine genotype of a…”
Get full text

Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis by NIKKARI, S. T, O'BRIEN, K. D, FERGUSON, M, HATSUKAMI, T, WELGUS, H. G, ALPERS, C. E, CLOWES, A. W

“…In human atherosclerosis, most clinical events occur when plaque integrity is compromised and hemorrhage and thrombosis result. One mechanism for this might be…”
Get full text

Food allergy in small children carries a risk of essential fatty acid deficiency, as detected by elevated serum mead acid proportion of total fatty acids by Paassilta, Marita, Kuusela, Elina, Korppi, Matti, Lemponen, Riina, Kaila, Minna, Nikkari, Seppo T

“…Elevated serum Mead acid as a proportion of total fatty acids is an indirect marker of a deficiency of essential fatty acids (EFA). The aim of the study was to…”
Get full text

Identification of different bacterial DNAs in human coronary arteries by Lehtiniemi, J., Karhunen, P. J., Goebeler, S., Nikkari, S., Nikkari, S. T.

“…Background  Various studies have suggested a link between infection, atherosclerosis and coronary artery disease. We studied whether bacterial DNA is present…”
Get full text

Contribution of SLC7A1 genetic variant to hypertension, the TAMRISK study by Määttä, Kirsi, Kunnas, Tarja, Nikkari, Seppo T

“…The rs41318021 polymorphism in the SLC7A1 gene affects endothelial NO production through changes in L-arginine transport. This variation could thus…”
Get full text

Periodic cohort health examinations in the TAMRISK study show untoward increases in body mass index and blood pressure during 15 years of follow-up by Kunnas, Tarja, Määttä, Kirsi, Palmroos, Pirjo, Nikkari, Seppo T

“…Obesity is a significant risk factor for hypertension and diabetes. A cohort of 50-year-old voluntary periodic health examination (PHE) participants was…”
Get full text

Bacterial signatures in atherosclerotic lesions represent human commensals and pathogens by Renko, Jaana, Lepp, Paul W, Oksala, Niku, Nikkari, Simo, Nikkari, Seppo T

“…Abstract Background Various studies have suggested the involvement of infectious agents in chronic inflammatory diseases, including atherosclerosis. By using a…”
Get full text

Late-life coronary heart disease mortality of Finnish war veterans in the TAMRISK study, a 28-year follow-up by Kunnas, Tarja, Solakivi, Tiina, Renko, Jaana, Kalela, Anne, Nikkari, Seppo T

“…Wartime stress has been associated with increased late-life mortality of all causes of death. We evaluated whether wounded Finnish World War II veterans who…”
Get full text

Variant rs6749447 (T > G) in the serine threonine kinase gene is associated with cardiovascular complications, the Tampere adult population cardiovascular risk study by Kunnas, Tarja, Määttä, Kirsi, Nikkari, Seppo T.

“…We have previously shown an association of STK39 (serine threonine kinase) rs6749447 (T > G) with hypertension in the Tampere adult population cardiovascular…”
Get full text

Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis by Nikkari, ST, Hoyhtya, M, Isola, J, Nikkari, T

“…Inflammation precedes erosion and rupture of atherosclerotic atheromas and aneurysms. Inflammatory infiltrates of macrophages have been shown to secrete…”
Get full text

Association of a Chromosome Locus 9p21.3 CDKN2B-AS1 Variant rs4977574 with Hypertension: The TAMRISK Study by Kunnas, Tarja, Piesanen, Jaakko, Nikkari, Seppo T

“…Chromosome locus 9p21.3 CDKN2B antisense RNA 1 (CDKN2B-AS1) has been found to contain multiple genetic markers for coronary artery disease (CAD) by genome-wide…”
Get more information

Matrix metalloproteinase-9 is elevated in serum of alcohol abusers by Sillanaukee, P., Kalela, A., Seppä, K., Höyhtyä, M., Nikkari, S. T.

“…Background Moderate alcohol consumption has been shown to protect against coronary heart disease. However, excessive alcohol use has been suggested to have…”
Get full text

Serum matrix metalloproteinase-9 concentration in angiographically assessed coronary artery disease by Kalela, A., Koivu, T. A., Sisto, T., Kanervisto, J., Höyhtyä, M, Sillanaukee, P., Lehtimäki, T., Nikkari, S. T.

“…Expression of several matrix metalloproteinases (MMPs) in atherosclerotic plaques has been well documented, and there are findings to indicate that arterial…”
Get full text

Association of Desmin Gene Variant rs1058261 with Cardiovascular Disease, the TAMRISK Study by Piesanen, Jaakko, Kunnas, Tarja, Nikkari, Seppo T

“…Since desmin expression is diminished in vascular smooth muscle cells during reparative processes, we wanted to study whether a common intragenic single…”
Get more information

Smooth muscle cell expression of extracellular matrix genes after arterial injury by Nikkari, ST, Jarvelainen, HT, Wight, TN, Ferguson, M, Clowes, AW

“…Accumulation of extracellular matrix (ECM) after arterial injury is an important event in the development of intimal thickening and is modulated by heparin. To…”
Get full text