Search Results - "Nikiforova, Anna B"
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Regulation of Mitochondrial Permeability Transition Pore Opening by Monovalent Cations in Liver Mitochondria
Published in International journal of molecular sciences (25-05-2023)“…The opening of the permeability transition pore (PTP) in mitochondria is a key event in the initiation of cell death in various pathologic states, including…”
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Warm Cells, Hot Mitochondria: Achievements and Problems of Ultralocal Thermometry
Published in International journal of molecular sciences (01-12-2023)“…Temperature is a crucial regulator of the rate and direction of biochemical reactions and cell processes. The recent data indicating the presence of local…”
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Amyloid Aβ25-35 Aggregates Say ‘NO’ to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na+/Ca2+ Exchanger
Published in International journal of molecular sciences (06-10-2022)“…The search for strategies for strengthening the synaptic efficiency in Aβ25-35-treated slices is a challenge for the compensation of amyloidosis-related…”
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Renal Glomerular Mitochondria Function in Salt-Sensitive Hypertension
Published in Frontiers in physiology (04-02-2020)“…Salt-sensitive (SS) hypertension is accompanied with an early onset of proteinuria, which results from the loss of glomerular podocytes. Here, we hypothesized…”
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Pioglitazone Is a Mild Carrier-Dependent Uncoupler of Oxidative Phosphorylation and a Modulator of Mitochondrial Permeability Transition
Published in Pharmaceuticals (Basel, Switzerland) (14-10-2021)“…Pioglitazone (PIO) is an insulin-sensitizing antidiabetic drug, which normalizes glucose and lipid metabolism but may provoke heart and liver failure and…”
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Mitochondrial F-ATP Synthase Co-Migrating Proteins and Ca2+-Dependent Formation of Large Channels
Published in Cells (Basel, Switzerland) (07-10-2023)“…Monomers, dimers, and individual FOF1-ATP synthase subunits are, presumably, involved in the formation of the mitochondrial permeability transition pore (PTP),…”
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Dynamics of the permeability transition pore size in isolated mitochondria and mitoplasts
Published in The FASEB journal (01-08-2021)“…The size of the permeability transition pore (PTP) is accepted to be ≤1.5 kDa. However, different authors reported values from 650 to 4000 Da. The present…”
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The Switching of the Type of a ROS Signal from Mitochondria: The Role of Respiratory Substrates and Permeability Transition
Published in Antioxidants (29-10-2024)“…Flashes of superoxide anion (O2−) in mitochondria are generated spontaneously or during the opening of the permeability transition pore (mPTP) and a sudden…”
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Regulation of mitochondria function by natriuretic peptides
Published in American journal of physiology. Renal physiology (01-11-2019)“…Natriuretic peptides (NPs) are well known to promote renal Na excretion, counteracting the effects of the renin-angiotensin-aldosterone system. Thus, NPs serve…”
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Pyridine nucleotides regulate the superoxide anion flash upon permeabilization of mitochondrial membranes: An MCLA-based study
Published in Free radical biology & medicine (20-08-2018)“…The permeabilization of mitochondrial membranes via permeability transition pore opening or by the pore-forming peptide alamethicin causes a flash of…”
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External mitochondrial NADH-dependent reductase of redox cyclers: VDAC1 or Cyb5R3?
Published in Free radical biology & medicine (01-09-2014)“…It was reported that VDAC1 possesses an NADH oxidoreductase activity and plays an important role in the activation of xenobiotics in the outer mitochondrial…”
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Regulation of permeability transition pore opening in mitochondria by external NAD(H)
Published in Biochimica et biophysica acta. General subjects (01-05-2019)“…The opening of the permeability transition pore (PTP) in mitochondria plays a critical role in the pathogenesis of numerous diseases. Mitochondrial matrix…”
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Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria
Published in Journal of bioenergetics and biomembranes (01-06-2017)“…Chronic alcohol intoxication is associated with increased oxidative stress. However, the mechanisms by which ethanol triggers an increase in the production of…”
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Rapid fluorescent visualization of multiple NAD(P)H oxidoreductases in homogenate, permeabilized cells, and tissue slices
Published in Analytical biochemistry (15-09-2013)“…Intracellular NAD(P)H oxidoreductases are a class of diverse enzymes that are the key players in a number of vital processes. The method we present and…”
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Sulfur-containing compounds quench 3,7-dihydro-2-methyl-6-(4-methoxyphenyl)imidazol[1,2- a]pyrazine-3-one chemiluminescence: Discrimination between true antioxidants and quenchers using xanthine oxidase
Published in Analytical biochemistry (15-11-2010)“…The probe 3,7-dihydro-2-methyl-6-(4-methoxyphenyl)imidazol[1,2- a]pyrazine-3-one (MCLA) is widely used for studying the superoxide anion production and the…”
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