Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells

The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isola...

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Bibliographic Details
Published in:	Science advances Vol. 9; no. 34; p. eadg1610
Main Authors:	Gallardo-Dodd, Carlos J., Oertlin, Christian, Record, Julien, Galvani, Rômulo G., Sommerauer, Christian, Kuznetsov, Nikolai V., Doukoumopoulos, Evangelos, Ali, Liaqat, Oliveira, Mariana M. S., Seitz, Christina, Percipalle, Mathias, Nikić, Tijana, Sadova, Anastasia A., Shulgina, Sofia M., Shmarov, Vjacheslav A., Kutko, Olga V., Vlasova, Daria D., Orlova, Kseniya D., Rykova, Marina P., Andersson, John, Percipalle, Piergiorgio, Kutter, Claudia, Ponomarev, Sergey A., Westerberg, Lisa S.
Format:	Journal Article
Language:	English
Published:	American Association for the Advancement of Science 25-08-2023
Subjects:	Biomedicine and Life Sciences Immunology Medicin och hälsovetenskap SciAdv r-articles Space Sciences
Online Access:	Get full text
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Summary:	The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14, and 21 during DI, and 7 days after DI. RNA sequencing of CD3 + T cells revealed transcriptional alterations across all time points, with most changes occurring 14 days after DI exposure. At day 21, T cells showed evidence of adaptation with a transcriptional profile resembling that of 7 days before DI. At 7 days after DI, T cells again changed their transcriptional profile. These data suggest that T cells adapt by rewiring their transcriptomes in response to simulated weightlessness and that remodeling cues persist when reexposed to normal gravity. Microgravity exposure reveals adaptation of immune cells with implication for therapeutic approaches for manned space missions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. Present address: Institute of Science and Technology Austria, Klosterneuburg, Austria.
ISSN:	2375-2548 2375-2548
DOI:	10.1126/sciadv.adg1610