Search Results - "Nikesjö, Johan"
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Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism
Published in eLife (01-06-2022)“…The K 7.4 and K 7.5 subtypes of voltage-gated potassium channels play a role in important physiological processes such as sound amplification in the cochlea…”
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Identification of PUFA interaction sites on the cardiac potassium channel KCNQ1
Published in The Journal of general physiology (07-06-2021)“…Polyunsaturated fatty acids (PUFAs), but not saturated fatty acids, modulate ion channels such as the cardiac KCNQ1 channel, although the mechanism is not…”
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Long-QT mutations in KCNE1 modulate the 1713-estradiol response of Kv7.1/KCNE1
Published in Science advances (17-03-2023)“…Estradiol (1713-E2) is implicated in higher arrhythmia risk of women with congenital or acquired long-QT syn-drome (LQTS) compared to men. However, the…”
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Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval
Published in EBioMedicine (01-03-2023)“…Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown…”
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Endocannabinoid-like compounds as modulators of the cardiac kv7.1/KCNE1 channel
Published in Biophysical journal (11-02-2022)Get full text
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Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1
Published in Science advances (17-03-2023)“…Estradiol (17[Formula: see text]-E2) is implicated in higher arrhythmia risk of women with congenital or acquired long-QT syndrome (LQTS) compared to men…”
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Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT intervalResearch in context
Published in EBioMedicine (01-03-2023)“…Background: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with…”
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Endocannabinoids enhance hK V 7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval
Published in EBioMedicine (01-03-2023)“…Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown…”
Get full text
Journal Article