Search Results - "Nijsen, Johannes F W"

Holmium-166 radioembolisation in patients with unresectable, chemorefractory liver metastases (HEPAR trial): a phase 1, dose-escalation study by Smits, Maarten LJ, MD, Nijsen, Johannes FW, PhD, van den Bosch, Maurice AAJ, Prof, Lam, Marnix GEH, PhD, Vente, Maarten AD, PhD, Mali, Willem PTM, Prof, van het Schip, Alfred D, PhD, Zonnenberg, Bernard A, Dr

“…Summary Background The efficacy of radioembolisation for the treatment of liver tumours depends on the selective distribution of radioactive microspheres to…”
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The necessity of nuclear reactors for targeted radionuclide therapies by Krijger, Gerard C, Ponsard, Bernard, Harfensteller, Mark, Wolterbeek, Hubert T, Nijsen, Johannes W.F

“…Highlights • Nuclear reactors remain essential for the production of radionuclides for medicine. • The main reactors used will close before 2025. • Alternative…”
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MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation by van de Maat, Gerrit H., Seevinck, Peter R., Elschot, Mattijs, Smits, Maarten L. J., de Leeuw, Hendrik, van het Schip, Alfred D., Vente, Maarten A. D., Zonnenberg, Bernard A., de Jong, Hugo W. A. M., Lam, Marnix G. E. H., Viergever, Max A., van den Bosch, Maurice A. A. J., Nijsen, Johannes F. W., Bakker, Chris J. G.

“…Objectives To demonstrate the feasibility of MRI-based assessment of the intrahepatic Ho-PLLA-MS biodistribution after radioembolisation in order to estimate…”
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Holmium-166 radioembolization for the treatment of patients with liver metastases: design of the phase I HEPAR trial by Smits, Maarten L J, Nijsen, Johannes F W, van den Bosch, Maurice A A J, Lam, Marnix G E H, Vente, Maarten A D, Huijbregts, Julia E, van het Schip, Alfred D, Elschot, Mattijs, Bult, Wouter, de Jong, Hugo W A M, Meulenhoff, Pieter C W, Zonnenberg, Bernard A

“…Intra-arterial radioembolization with yttrium-90 microspheres ( 90Y-RE) is an increasingly used therapy for patients with unresectable liver malignancies. Over…”
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Liver tumors: MR imaging of radioactive holmium microspheres--phantom and rabbit study by Nijsen, Johannes F W, Seppenwoolde, Jan-Henry, Havenith, Thomas, Bos, Clemens, Bakker, Chris J G, van het Schip, Alfred D

“…To investigate the use of magnetic resonance (MR) imaging in the administration and biodistribution of holmium-loaded poly(L-lactic acid) microspheres…”
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Radioembolization Dosimetry: The Road Ahead by Smits, Maarten L. J., Elschot, Mattijs, Sze, Daniel Y., Kao, Yung H., Nijsen, Johannes F. W., Iagaru, Andre H., de Jong, Hugo W. A. M., van den Bosch, Maurice A. A. J., Lam, Marnix G. E. H.

“…Methods for calculating the activity to be administered during yttrium-90 radioembolization (RE) are largely based on empirical toxicity and efficacy analyses,…”
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Holmium-Loaded Poly(l-lactic Acid) Microspheres:  In Vitro Degradation Study by Zielhuis, Sander W, Nijsen, Johannes F. W, Krijger, Gerard C, van het Schip, Alfred D, Hennink, Wim E

“…The clinical application of holmium-loaded poly(l-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth…”
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Factors affecting the sensitivity and detection limits of MRI, CT, and SPECT for multimodal diagnostic and therapeutic agents by Seevinck, Peter R, Seppenwoolde, Jan-Henry, de Wit, Tim C, Nijsen, Johannes F W, Beekman, Freek J, van Het Schip, Alfred D, Bakker, Chris J G

“…Noninvasive imaging techniques like magnetic resonance imaging (MRI), computed tomography (CT) and single photon emission computed tomography (SPECT) play an…”
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The evolution of radioembolisation by Smits, Maarten LJ, van den Bosch, Maurice AAJ, Nijsen, Johannes FW, Zonnenberg, Bernard A

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Internal radiation therapy of liver tumors: Qualitative and quantitative magnetic resonance imaging of the biodistribution of holmium-loaded microspheres in animal models by Seppenwoolde, Jan-Henry, Nijsen, Johannes F. W., Bartels, Lambertus W., Zielhuis, Sander W., van het Schip, Alfred D., Bakker, Chris J. G.

“…In internal radiation therapy of unresectable liver tumors, microspheres containing a radionuclide are injected in the hepatic artery to achieve a preferential…”
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In vivo dosimetry based on SPECT and MR imaging of 166Ho-microspheres for treatment of liver malignancies by Smits, Maarten L J, Elschot, Mattijs, van den Bosch, Maurice A A J, van de Maat, Gerrit H, van het Schip, Alfred D, Zonnenberg, Bernard A, Seevinck, Peter R, Verkooijen, Helena M, Bakker, Chris J, de Jong, Hugo W A M, Lam, Marnix G E H, Nijsen, Johannes F W

“…(166)Ho-poly(l-lactic acid) microspheres allow for quantitative imaging with MR imaging or SPECT for microsphere biodistribution assessment after…”
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Radioembolization for colorectal liver metastases by Vente, Maarten A. D, van den Bosch, Maurice A. A. J, Lam, Marnix G. E. H, Nijsen, Johannes F. W

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Intratumoral injection of radioactive holmium-166 microspheres in recurrent head and neck squamous cell carcinoma: preliminary results of first use by Bakker, Robbert C, van Es, Robert J.J, Rosenberg, Antoine J.W.P, van Nimwegen, Sebastiaan A, Bastiaannet, Remco, de Jong, Hugo W.A.M, Nijsen, Johannes F.W, Lam, Marnix G.E.H

“…BACKGROUNDLimited treatment options exist for patients with locoregional recurrences of head and neck squamous cell carcinoma (HNSCC). In the palliative…”
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Quantitative Monte Carlo-based holmium-166 SPECT reconstruction by Elschot, Mattijs, Smits, Maarten L. J., Nijsen, Johannes F. W., Lam, Marnix G. E. H., Zonnenberg, Bernard A., van den Bosch, Maurice A. A. J., Viergever, Max A., de Jong, Hugo W. A. M.

“…Purpose: Quantitative imaging of the radionuclide distribution is of increasing interest for microsphere radioembolization (RE) of liver malignancies, to aid…”
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Radiation Emission from Patients Treated with Holmium-166 Radioembolization by Prince, Jip F., MD, Smits, Maarten L.J., MD, PhD, Krijger, Gerard C., PhD, Zonnenberg, Bernard A., MD, PhD, van den Bosch, Maurice A.A.J., MD, PhD, Nijsen, Johannes F.W., PhD, Lam, Marnix G.E.H., MD, PhD

“…Abstract Purpose To assess the radiation exposure to individuals coming from patients after treatment with holmium-166 (166 Ho) microspheres. Materials and…”
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Clinical and laboratory toxicity after intra-arterial radioembolization with (90)y-microspheres for unresectable liver metastases by Smits, Maarten L J, van den Hoven, Andor F, Rosenbaum, Charlotte E N M, Zonnenberg, Bernard A, Lam, Marnix G E H, Nijsen, Johannes F W, Koopman, Miriam, van den Bosch, Maurice A A J

“…To investigate clinical and laboratory toxicity in patients with unresectable liver metastases, treated with yttrium-90 radioembolization ((90)Y-RE). Patients…”
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Clinical and Laboratory Toxicity after Intra-Arterial Radioembolization with 90Y-Microspheres for Unresectable Liver Metastases by Smits, Maarten L. J., van den Hoven, Andor F., Rosenbaum, Charlotte E. N. M., Zonnenberg, Bernard A., Lam, Marnix G. E. H., Nijsen, Johannes F. W., Koopman, Miriam, van den Bosch, Maurice A. A. J.

“…Objective To investigate clinical and laboratory toxicity in patients with unresectable liver metastases, treated with yttrium-90 radioembolization (90Y-RE)…”
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Radionuclide liver cancer therapies: from concept to current clinical status by Vente, Maarten A D, Hobbelink, Monique G G, van Het Schip, Alfred D, Zonnenberg, Bernard A, Nijsen, Johannes F W

“…Primary and secondary liver cancer have longtime been characterized by an overall poor prognosis since the majority of patients are not candidates for surgical…”
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Microbrachytherapy using holmium-166 acetylacetonate microspheres: A pilot study in a spontaneous cancer animal model by Bult, Wouter, Vente, Maarten A.D, Vandermeulen, Eva, Gielen, Ingrid, Seevinck, Peter R, Saunders, Jimmy, van het Schip, Alfred D, Bakker, Chris J.G, Krijger, Gerard C, Peremans, Kathelijne, Nijsen, Johannes F.W

“…Abstract Purpose Holmium-166 acetylacetonate microspheres (166 Ho-AcAc-MS) are proposed as an intratumoral radioablation device. This article presents a pilot…”
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Lanthanide-loaded liposomes for multimodality imaging and therapy by Zielhuis, Sander W, Seppenwoolde, Jan-Henry, Mateus, Vanessa A P, Bakker, Chris J G, Krijger, Gerard C, Storm, Gert, Zonnenberg, Bernard A, van het Schip, Alfred D, Koning, Gerben A, Nijsen, Johannes F W

“…Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have proven to be very promising carrier systems…”
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