Search Results - "Nijenkamp, Louise L A M"
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Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy
Published in PloS one (05-05-2020)“…Hypertrophic cardiomyopathy (HCM) is the most frequent genetic cardiac disease with a prevalence of 1:500 to 1:200. While most patients show obstructive HCM…”
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The physiological role of cardiac cytoskeleton and its alterations in heart failure
Published in Biochimica et biophysica acta (01-02-2014)“…Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid generation of force and movement central to the work generated by the…”
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Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations
Published in Circulation research (24-05-2013)“…RATIONALE:High-myofilament Ca sensitivity has been proposed as a trigger of disease pathogenesis in familial hypertrophic cardiomyopathy (HCM) on the basis of…”
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Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy
Published in Circulation. Heart failure (01-06-2018)“…One of the first clinically detectable alterations in heart function in hypertrophic cardiomyopathy (HCM) is a decline in diastolic function. Diastolic…”
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Sex-dependent pathophysiological mechanisms in hypertrophic cardiomyopathy: Implications for rhythm disorders
Published in Heart rhythm (01-02-2015)“…Differences in cardiac physiology are seen between men and women in terms of health and disease. Sex differences start to develop at puberty and are maintained…”
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