Search Results - "Nijenhuis, C.M."

Development and validation of a high-performance liquid chromatography–tandem mass spectrometry assay quantifying olaparib in human plasma by Nijenhuis, C.M., Lucas, L., Rosing, H., Schellens, J.H.M., Beijnen, J.H.

“…•This assay was fully validated according to the latest FDA and EMA guidelines.•Liquid–liquid extraction was used as sample pretreatment with a deuterated…”
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Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma? by Nijenhuis, C.M, Haanen, J.B.A.G, Schellens, J.H.M, Beijnen, J.H

“…Abstract In the last few years, several drugs targeting signalling proteins critical for melanoma entered clinical evaluation. In 2011 vemurafenib (Zelboraf®,…”
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Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography–tandem mass spectrometry by Nijenhuis, C.M., Haverkate, H., Rosing, H., Schellens, J.H.M., Beijnen, J.H.

“…[Display omitted] •This is the first assay quantifying dabrafenib and trametinib simultaneously.•This assay was validated according to the latest US FDA…”
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Development and validation of a high-performance liquid chromatography–tandem mass spectrometry assay quantifying vemurafenib in human plasma by Nijenhuis, C.M., Rosing, H., Schellens, J.H.M., Beijnen, J.H.

“…•This assay was fully validated according to the latest FDA and EMA guidelines.•The validation is compliant with the OECD principles of Good Laboratory…”
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Quantification of vosaroxin and its metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine using high-performance liquid chromatography-tandem mass spectrometry by Nijenhuis, C.M., Lucas, L., Rosing, H., Jamieson, G., Fox, J.A., Schellens, J.H.M., Beijnen, J.H.

“…•These are the first reported validated assays for vosaroxin in plasma and urine.•N-desmethylvosaroxin was included in the quantification of plasma and…”
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Validation of high-performance liquid chromatography–tandem mass spectrometry assays quantifying omacetaxine mepesuccinate and its 4′‑des-methyl and cephalotaxine metabolites in human plasma and urine by Nijenhuis, C.M., Lucas, L., Rosing, H., Schellens, J.H.M., Beijnen, J.H., Gorman, S.H., Burke, S.M., Campbell, D.A., Chapple, M.W., Yousey, T.H., Mulvana, D.E.

“…•These assays were fully validated according to the latest FDA and EMA guidelines.•Deuterated isotopes were used as internal standards.•The assays were…”
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Metabolism and disposition of the anticancer quinolone derivative vosaroxin, a novel inhibitor of topoisomerase II by Nijenhuis, C.M., Lucas, L., Rosing, H., Huitema, A.D.R., Mergui-Roelvink, M., Jamieson, G. C., Fox, J.A., Mould, D.R., Schellens, J.H.M., Beijnen, J.H.

“…Summary Background Vosaroxin is a first-in-class anticancer quinolone derivative that is being investigated for patients with relapsed or refractory acute…”
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