Search Results - "Niisato, Naomi"

Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus by Niisato, Naomi, Marunaka, Yoshinori

“…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and insufficient insulin secretion. It is…”
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Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance by Hayata, Hiroki, Miyazaki, Hiroaki, Niisato, Naomi, Yokoyama, Noriko, Marunaka, Yoshinori

“…•Low pH media diminish activation of insulin receptor in L6 skeletal muscle cells.•Akt phosphorylation is also decreased by low pH media in L6 cells.•Low pH…”
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Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus by Hosogi, Shigekuni, Kuwahara, Atsukazu, Kuwahara, Yuko, Tanaka, Saori, Shimamoto, Chikao, Tagawa, Noriko, Kato, Ikuo, Yoshimoto, Kanji, Aoi, Wataru, Takata, Kazuyuki, Miyazaki, Hiroaki, Niisato, Naomi, Tsubo, Yasuhiro, Yagi, Katsumi, Nakahari, Takashi, Marunaka, Yoshinori

“…The present study tried to clarify if mumefural would prevent hyperglycemia, one of the typical symptoms of type 2 diabetes mellitus (T2DM), since mumefural is…”
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Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin resistance in OLETF rats by intake of propolis extracts by Aoi, Wataru, Hosogi, Shigekuni, Niisato, Naomi, Yokoyama, Noriko, Hayata, Hiroki, Miyazaki, Hiroaki, Kusuzaki, Katsuyuki, Fukuda, Takuya, Fukui, Michiaki, Nakamura, Naoto, Marunaka, Yoshinori

“…► Propolis suppresses elevations of blood glucose and plasma insulin in OLETF rats. ► Systolic arterial pressure in OLETF rats elevates. ► The elevated…”
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Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells by Ohsawa, Rumi, Miyazaki, Hiroaki, Niisato, Naomi, Shiozaki, Atsushi, Iwasaki, Yoshinobu, Otsuji, Eigo, Marunaka, Yoshinori

“…Recently, we reported that reduction of intracellular Cl− concentration ([Cl−]i) inhibited proliferation of MKN28 gastric cancer cells by diminishing the…”
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Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl(-) channel through PI3K activation and ERK inactivation in renal epithelial cells by Sun, Hongxin, Niisato, Naomi, Inui, Toshio, Marunaka, Yoshinori

“…It is is well known that insulin stimulates glucose transport and epithelial Na(+) channel (ENaC)-mediated Na(+) reabsorption; however, the action of insulin…”
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Quercetin is a Useful Medicinal Compound Showing Various Actions Including Control of Blood Pressure, Neurite Elongation and Epithelial Ion Transport by Marunaka, Yoshinori, Niisato, Naomi, Miyazaki, Hiroaki, Nakajima, Ken-Ichi, Taruno, Akiyuki, Sun, Hongxin, Marunaka, Rie, Okui, Motoki, Yamamoto, Toshiro, Kanamura, Narisato, Kogiso, Haruka, Ikeuchi, Yukiko, Kashio, Makiko, Hosogi, Shigekuni, Nakahari, Takashi

“…Quercetin has multiple potential to control various cell function keeping our body condition healthy. In this review article, we describe the molecular…”
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Quercetin Stimulates NGF-induced Neurite Outgrowth in PC12 Cells via Activation of Na+/K+/2Cl- Cotransporter by Nakajima, Ken-ichi, Niisato, Naomi, Marunaka, Yoshinori

“…We have recently reported that Na + /K + /2Cl - cotransporter isoform 1 (NKCC1) plays an essential role in nerve growth factor (NGF)-induced neurite outgrowth…”
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Enhancement of tubulin polymerization by Cl−-induced blockade of intrinsic GTPase by Nakajima, Ken-ichi, Niisato, Naomi, Marunaka, Yoshinori

“…► Tubulin polymerization (TP) was higher in Cl− solutions than that in Br- or NO3-. ► GTPase activity of tubulin was lower in Cl− solutions than that in…”
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Physiological significance of hypotonicity-induced regulatory volume decrease: reduction in intracellular Cl- concentration acting as an intracellular signaling by Miyazaki, Hiroaki, Shiozaki, Atsushi, Niisato, Naomi, Marunaka, Yoshinori

“…Regulatory volume decrease (RVD) occurs after hypotonicity-caused cell swelling. RVD is caused by activation of ion channels and transporters, which cause…”
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Food intake targeting and improving acidity in diabetes and cancer by Marunaka, Yoshinori, Niisato, Naomi, Zou, Xiaobo, Xiao, Jian Bo, Nakahari, Takashi

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Distinct Action of Flavonoids, Myricetin and Quercetin, on Epithelial Cl− Secretion : Useful Tools as Regulators of Cl− Secretion by Sun, Hongxin, Niisato, Naomi, Nishio, Kyosuke, Hamilton, Kirk L., Marunaka, Yoshinori

“…Epithelial Cl− secretion plays important roles in water secretion preventing bacterial/viral infection and regulation of body fluid. We previously suggested…”
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Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells by Taruno, Akiyuki, Niisato, Naomi, Marunaka, Yoshinori

“…In A6 cells, a renal cell line derived from Xenopus laevis, hypotonic stress stimulates the amiloride-sensitive Na(+) transport. Hypotonic action on Na(+)…”
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Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases by Taruno, Akiyuki, Niisato, Naomi, Marunaka, Yoshinori

“…We previously reported that hypotonic stress stimulated transepithelial Na(+) transport via a pathway dependent on protein tyrosine kinase (PTK; Niisato N, Van…”
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A regulatory role of K+–Cl− cotransporter in the cell cycle progression of breast cancer MDA-MB-231 cells by Kitagawa, Maki, Niisato, Naomi, Shiozaki, Atsushi, Ohta-Fujimoto, Mariko, Hosogi, Shigekuni, Miyazaki, Hiroaki, Ichikawa, Daisuke, Otsuji, Eigo, Marunaka, Yoshinori

“…•DIOA, an inhibitor of K+–Cl− cotransporter (KCC), induced an increase in cell volume.•DIOA induced a decrease in intracellular Cl− concentration.•DIOA…”
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Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model by Sasamoto, Kouhei, Marunaka, Rie, Niisato, Naomi, Sun, Hongxin, Taruno, Akiyuki, Pezzotti, Giuseppe, Yamamoto, Toshiro, Kanamura, Narisato, Zhu, Wenliang, Nishio, Kyosuke, Inui, Toshio, Eaton, Douglas C., Marunaka, Yoshinori

“…Background/Aim: Epithelial Na + channels (ENaC) play a crucial role in control of blood pressure by regulating renal Na + reabsorption. Intracellular…”
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Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter by Sasamoto, Kouhei, Niisato, Naomi, Taruno, Akiyuki, Marunaka, Yoshinori

“…Transcellular Cl(-) secretion is, in general, mediated by two steps; (1) the entry step of Cl(-) into the cytosolic space from the basolateral space across the…”
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An Inhibitor of Na+/H+ Exchanger (NHE), Ethyl-Isopropyl Amiloride (EIPA), Diminishes Proliferation of MKN28 Human Gastric Cancer Cells by Decreasing the Cytosolic Cl- Concentration via DIDS-Sensitive Pathways by Hosogi, Shigekuni, Miyazaki, Hiroaki, Nakajima, Ken-ichi, Ashihara, Eishi, Niisato, Naomi, Kusuzaki, Katsuyuki, Marunaka, Yoshinori

“…Background/Aims: Tumor cells produce a large amount of acidic metabolites due to their high metabolic condition. However, cytosolic pH (pH c ) of tumor cells…”
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Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state by Shiozaki, Atsushi, Miyazaki, Hiroaki, Niisato, Naomi, Nakahari, Takashi, Iwasaki, Yoshinobu, Itoi, Hirosumi, Ueda, Yuji, Yamagishi, Hisakazu, Marunaka, Yoshinori

“…Furosemide, a blocker of Na(+)/K(+)/2Cl(-) cotransporter (NKCC), is often used as a diuretic to improve edema, ascites, and pleural effusion of patients with…”
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Genistein enhances the NGF-induced neurite outgrowth by Nakajima, Ken-ichi, Niisato, Naomi, Marunaka, Yoshinori

“…In the present report, we studied if an isoflavone, genistein, enhances the nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells. Application of…”
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