Search Results - "Niimi, Tomoaki"

Recombinant protein production in the eukaryotic protozoan parasite Leishmania tarentolae: a review by Niimi, Tomoaki

“…Leishmania tarentolae is a trypanosomatid protozoan parasite of the gecko, and has been established as a new eukaryotic expression system for the production of…”
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Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2 by Yamamoto, Naoka, Kashiwagi, Manabu, Ishihara, Manami, Kojima, Takaaki, Maturana, Andrés D., Kuroda, Shun’ichi, Niimi, Tomoaki

“…The signaling pathways that are mediated by Slit ligands and their Roundabout (Robo) family of receptors play multifunctional roles in the development of the…”
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RBM20 Regulates CaV1.2 Surface Expression by Promoting Exon 9 Inclusion of CACNA1C in Neonatal Rat Cardiomyocytes by Morinaga, Akihito, Ito, Jumpei, Niimi, Tomoaki, Maturana, Andrés D

“…The gene encodes for the CaV1.2 protein, which is the pore subunit of cardiac l-type voltage-gated calcium (Ca ) channels (l-channels). Through alternative…”
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RBM20 and RBM24 cooperatively promote the expression of short enh splice variants by Ito, Jumpei, Iijima, Masumi, Yoshimoto, Nobuo, Niimi, Tomoaki, Kuroda, Shun'ichi, Maturana, Andrés D.

“…PDZ‐LIM protein ENH1 is a scaffold protein for protein kinases and transcriptional regulators. While ENH1 promotes the hypertrophic growth of cardiomyocytes,…”
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Nano-visualization of oriented-immobilized IgGs on immunosensors by high-speed atomic force microscopy by Iijima, Masumi, Somiya, Masaharu, Yoshimoto, Nobuo, Niimi, Tomoaki, Kuroda, Shun'ichi

“…Oriented immobilization of sensing molecules on solid phases is an important issue in biosensing. In case of immunosensors, it is essential to scrutinize not…”
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Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression by Ito, Jumpei, Minemura, Tomomi, Wälchli, Sébastien, Niimi, Tomoaki, Fujihara, Yoshitaka, Kuroda, Shun'ichi, Takimoto, Koichi, Maturana, Andrés D

“…Aldosterone excess is a cardiovascular risk factor. Aldosterone can directly stimulate an electrical remodeling of cardiomyocytes leading to cardiac arrhythmia…”
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Intracellular trafficking of bio-nanocapsule–liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein by Somiya, Masaharu, Sasaki, Yasuo, Matsuzaki, Takashi, Liu, Qiushi, Iijima, Masumi, Yoshimoto, Nobuo, Niimi, Tomoaki, Maturana, Andrés Daniel, Kuroda, Shun'ichi

“…Bio-nanocapsules (BNCs) are a hollow nanoparticle consisting of about 100-nm liposome (LP) embedding about 110 molecules of hepatitis B virus (HBV) surface…”
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Mapping the heparin-binding site of the osteoinductive protein NELL1 by site-directed mutagenesis by Takahashi, Kaneyoshi, Imai, Arisa, Iijima, Masumi, Yoshimoto, Nobuo, Maturana, Andrés D., Kuroda, Shun’ichi, Niimi, Tomoaki

“…•NELL1 interacts with cell surface HSPGs through its N-terminal TSPN domain.•The apparent Kd for the interaction of NELL1 for immobilized heparin was…”
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Exploring dynamics of molybdate in living animal cells by a genetically encoded FRET nanosensor by Nakanishi, Yoichi, Iida, Syuntaro, Ueoka-Nakanishi, Hanayo, Niimi, Tomoaki, Tomioka, Rie, Maeshima, Masayoshi

“…Molybdenum (Mo) is an essential trace element for almost all living organisms including animals. Mo is used as a catalytic center of molybdo-enzymes for…”
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Scaffold protein enigma homolog activates CREB whereas a short splice variant prevents CREB activation in cardiomyocytes by Ito, Jumpei, Iijima, Masumi, Yoshimoto, Nobuo, Niimi, Tomoaki, Kuroda, Shun’ichi, Maturana, Andrés D.

“…Enigma Homolog (ENH1 or Pdlim5) is a scaffold protein composed of an N-terminal PDZ domain and three LIM domains at the C-terminal end. The enh gene encodes…”
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NELL-1 promotes cell adhesion and differentiation via integrinβ1 by Shen, Jia, James, Aaron W., Chung, Jonguk, Lee, Kiho, Zhang, James B., Ho, Stephanie, Lee, Kevin S., Kim, Toyong M., Niimi, Tomoaki, Kuroda, Shun'ichi, Ting, Kang, Soo, Chia

“…NELL‐1 (Nel‐like molecule‐1) is a secreted osteogenic growth factor first identified in human craniosynostosis (CS) patients. NELL‐1 protein has been observed…”
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Fluorophore-labeled nanocapsules displaying IgG Fc-binding domains for the simultaneous detection of multiple antigens by Iijima, Masumi, Matsuzaki, Takashi, Yoshimoto, Nobuo, Niimi, Tomoaki, Tanizawa, Katsuyuki, Kuroda, Shun’ichi

“…Abstract Simultaneous detection of multiple antigens by conventional immunological methods has been limited by the source of primary antibodies. Each antibody…”
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Nanocapsules incorporating IgG Fc-binding domain derived from Staphylococcus aureus protein A for displaying IgGs on immunosensor chips by Iijima, Masumi, Kadoya, Hiroyasu, Hatahira, Satoko, Hiramatsu, Shingo, Jung, Giman, Martin, Aaron, Quinn, John, Jung, Joohee, Jeong, Seong-Yun, Choi, Eun Kyung, Arakawa, Takeshi, Hinako, Fumiyo, Kusunoki, Masanobu, Yoshimoto, Nobuo, Niimi, Tomoaki, Tanizawa, Katsuyuki, Kuroda, Shun’ichi

“…Abstract To enhance the sensitivities and antigen-binding capacities of immunosensors, oriented immobilization of antibodies on the surface of the sensor chip…”
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Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2 by Nakatani, Miyuki, Ito, Jumpei, Koyama, Riko, Iijima, Masumi, Yoshimoto, Nobuo, Niimi, Tomoaki, Kuroda, Shun'ichi, Maturana, Andrés D.

“…Enigma Homolog 1 (ENH1) is a scaffold protein for signaling proteins and transcription factors. Previously, we reported that ENH1 overexpression promotes the…”
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The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin α3β1 by Hasebe, Ai, Nakamura, Yoko, Tashima, Hiroki, Takahashi, Kaneyoshi, Iijima, Masumi, Yoshimoto, Nobuo, Ting, Kang, Kuroda, Shun’ichi, Niimi, Tomoaki

“…► NELL1 promotes osteoblastic cell adhesion. ► Three cell-binding sites are localized to the C-terminal region of NELL1. ► Integrin α3β1 is the major receptor…”
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Virosomes of hepatitis B virus envelope L proteins containing doxorubicin: synergistic enhancement of human liver-specific antitumor growth activity by radiotherapy by Liu, Qiushi, Jung, Joohee, Somiya, Masaharu, Iijima, Masumi, Yoshimoto, Nobuo, Niimi, Tomoaki, Maturana, Andrés D, Shin, Seol Hwa, Jeong, Seong-Yun, Choi, Eun Kyung, Kuroda, Shun'ichi

“…Bionanocapsules (BNCs) are hollow nanoparticles consisting of hepatitis B virus (HBV) envelope L proteins and have been shown to deliver drugs and genes…”
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SOX7 and SOX17 Regulate the Parietal Endoderm-specific Enhancer Activity of Mouse Laminin α1 Gene by Niimi, Tomoaki, Hayashi, Yoshitaka, Futaki, Sugiko, Sekiguchi, Kiyotoshi

“…Laminin-1 is the major component of embryonic basement membrane and consists of α1, β1, and γ1 chains. The expression of laminin-1 is induced in mouse F9…”
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Oligomerization-induced Conformational Change in the C-terminal Region of Nel-like Molecule 1 (NELL1) Protein Is Necessary for the Efficient Mediation of Murine MC3T3-E1 Cell Adhesion and Spreading by Nakamura, Yoko, Hasebe, Ai, Takahashi, Kaneyoshi, Iijima, Masumi, Yoshimoto, Nobuo, Maturana, Andrés D., Ting, Kang, Kuroda, Shun'ichi, Niimi, Tomoaki

“…NELL1 is a large oligomeric secretory glycoprotein that functions as an osteoinductive factor. NELL1 contains several conserved domains, has structural…”
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Nanocapsule-based probe for evaluating the orientation of antibodies immobilized on a solid phase by Iijima, Masumi, Yoshimoto, Nobuo, Niimi, Tomoaki, Maturana, Andrés Daniel, Kuroda, Shun'ichi

“…The orientation of sensing molecules on solid phase biosensors has to be optimized to facilitate efficient binding of analytes. Since conventional observation…”
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The production of recombinant human laminin-332 in a Leishmania tarentolae expression system by Phan, Hoang-Phuong, Sugino, Marisa, Niimi, Tomoaki

“…Laminin (LM)-332 (α3β3γ2), a large heterotrimeric glycoprotein, is an essential component of epithelial basement membranes that promotes cell adhesion and…”
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