Search Results - "Niijima, Satoshi"

Dissecting Kinase Profiling Data to Predict Activity and Understand Cross-Reactivity of Kinase Inhibitors by Niijima, Satoshi, Shiraishi, Akira, Okuno, Yasushi

“…The development of selective and multitargeted kinase inhibitors has received much attention, because cross-reactivity with unintended targets may cause toxic…”
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Analysis of multiple compound-protein interactions reveals novel bioactive molecules by Okuno, Yasushi, Yabuuchi, Hiroaki, Niijima, Satoshi, Takematsu, Hiromu, Ida, Tomomi, Hirokawa, Takatsugu, Hara, Takafumi, Ogawa, Teppei, Minowa, Yohsuke, Tsujimoto, Gozoh

“…The discovery of novel bioactive molecules advances our systems‐level understanding of biological processes and is crucial for innovation in drug development…”
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Validation of novel identification algorithms for major adverse cardiovascular events in a Japanese claims database by Shima, Daisuke, Ii, Yoichi, Higa, Shingo, Kohro, Takahide, Hoshide, Satoshi, Kono, Ken, Fujimoto, Shigeru, Niijima, Satoshi, Tomitani, Naoko, Kario, Kazuomi

“…Predicting clinical outcomes can be difficult, particularly for life‐threatening events with a low incidence that require numerous clinical cases. Our aim was…”
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Long sleep duration: a nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: the J-HOP study by Niijima, Satoshi, Nagai, Michiaki, Hoshide, Satoshi, Takahashi, Mami, Shimpo, Masahisa, Kario, Kazuomi

“…Long and short sleep durations were reported as independently associated with hypertension, aortic stiffness, and cardiovascular disease. High-sensitivity…”
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Differential impact of diabetes mellitus on antiplatelet effects of prasugrel and clopidogrel by Niijima, Satoshi, Ohmori, Tsukasa, Kario, Kazuomi

“…Although prasugrel exerts stronger antiplatelet effects compared with clopidogrel, the factors affecting platelet reactivity under prasugrel have not been…”
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Cross-Target View to Feature Selection: Identification of Molecular Interaction Features in Ligand−Target Space by Niijima, Satoshi, Yabuuchi, Hiroaki, Okuno, Yasushi

“…There is growing interest in computational chemogenomics, which aims to identify all possible ligands of all target families using in silico prediction models…”
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Recursive gene selection based on maximum margin criterion: a comparison with SVM-RFE by Niijima, Satoshi, Kuhara, Satoru

“…In class prediction problems using microarray data, gene selection is essential to improve the prediction accuracy and to identify potential marker genes for a…”
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Chemical Genomics Approach for GPCR–Ligand Interaction Prediction and Extraction of Ligand Binding Determinants by Shiraishi, Akira, Niijima, Satoshi, Brown, J. B, Nakatsui, Masahiko, Okuno, Yasushi

“…Chemical genomics research has revealed that G-protein coupled receptors (GPCRs) interact with a variety of ligands and that a large number of ligands are…”
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CompoundProtein Interaction Prediction Within Chemogenomics: Theoretical Concepts, Practical Usage, and Future Directions by Brown, J. B., Niijima, Satoshi, Okuno, Yasushi

“…With advancements in high‐throughput technologies and open availability of bioassay data, computational methods to generate models, that zoom out from a single…”
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GEM-TREND: a web tool for gene expression data mining toward relevant network discovery by Feng, Chunlai, Araki, Michihiro, Kunimoto, Ryo, Tamon, Akiko, Makiguchi, Hiroki, Niijima, Satoshi, Tsujimoto, Gozoh, Okuno, Yasushi

“…DNA microarray technology provides us with a first step toward the goal of uncovering gene functions on a genomic scale. In recent years, vast amounts of gene…”
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Electron Microscopy of Contact Between a Monocyte and a Multinucleated Giant Cell in Cardiac Sarcoidosis by Imaizumi, Yuki, MD, Eguchi, Kazuo, MD, PhD, Imada, Hiroki, MD, Hidano, Kiyomi, Niijima, Satoshi, MD, Kawata, Hirotoshi, MD, Fukushima, Noriyoshi, MD, PhD, Saito, Tsunenori, MD, PhD, Hiroe, Michiaki, MD, PhD, Kario, Kazuomi, MD, PhD

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Platinum agent-induced hypersensitivity reactions: data mining of the public version of the FDA adverse event reporting system, AERS by Sakaeda, Toshiyuki, Kadoyama, Kaori, Yabuuchi, Hiroaki, Niijima, Satoshi, Seki, Kyoko, Shiraishi, Yukinari, Okuno, Yasushi

“…Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm the platinum agent-associated mild, severe, and…”
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Abstract 12026: Nocturnal Blood Pressure Burden, Diuretics, and Cardiac Load: Determinants of Nocturia in the Japanese at High-Risk of Cardiovascular Disease by Nagai, Michiaki, Niijima, Satoshi, Hoshide, Satoshi, Takahashi, Mami, Shimpo, Masahisa, Kario, Kazuomi

“…IntroductionThe majority of epidemiologic studies reported a significant relationship between hypertension and nocturia. However, the underlying…”
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GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update by Okuno, Yasushi, Tamon, Akiko, Yabuuchi, Hiroaki, Niijima, Satoshi, Minowa, Yohsuke, Tonomura, Koichiro, Kunimoto, Ryo, Feng, Chunlai

“…G-protein coupled receptors (GPCRs) represent one of the most important families of drug targets in pharmaceutical development. GLIDA is a public GPCR-related…”
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CompoundProtein Interaction Prediction Within Chemogenomics: Theoretical Concepts, Practical Usage, and Future Directions by Brown, J B, Niijima, Satoshi, Okuno, Yasushi

“…With advancements in high-throughput technologies and open availability of bioassay data, computational methods to generate models, that zoom out from a single…”
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Abstract 11600: Long Sleep Duration and Low-Grade Inflammation: New Indicators of Arterial Stiffness in the Japanese at High-risk of Cardiovascular Disease by Niijima, Satoshi, Nagai, Michiaki, Hoshide, Satoshi, Takahashi, Mami, Shimpo, Masahisa, Kario, Kazuomi

“…Abstract only Background: Recently, several studies have reported that long sleep duration was independently associated with increased aortic stiffness. On the…”
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Gene subset selection in kernel-induced feature space by Niijima, Satoshi, Kuhara, Satoru

“…This paper proposes a new filter approach to gene subset selection for kernel-based classifiers. We derive kernel forms of several well-known class…”
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Laplacian Linear Discriminant Analysis Approach to Unsupervised Feature Selection by Niijima, S., Okuno, Y.

“…Until recently, numerous feature selection techniques have been proposed and found wide applications in genomics and proteomics. For instance, feature/gene…”
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Chemogenomic approach to comprehensive predictions of ligand-target interactions: A comparative study by Brown, J. B., Niijima, S., Shiraishi, A., Nakatsui, M., Okuno, Y.

“…Chemogenomics has emerged as an interdisciplinary field that aims to ultimately identify all possible ligands of all target families in a systematic manner. An…”
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Abstract 12665: Is Low-Grade Inflammation the Mediator of the Relationship Between Sleep Duration and All-Cause Mortality in the Elderly at High-Risk of Cardiovascular Disease? by Nagai, Michiaki, Niijima, Satoshi, Hoshide, Satoshi, Shimpo, Masahisa, Kario, Kazuomi

“…IntroductionRecent studies have reported that short or long sleep duration was a significant predictor of mortality. Although low-grade inflammation was…”
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