Magnetic resonance imaging of the sacroiliac joints in SpA: with or without intravenous contrast media? A preliminary report

Magnetic resonance imaging of the sacroiliac joints in SpA: with or without intravenous contrast media? A preliminary report

Object Active sacroiliitis based on magnetic resonance imaging (MRI) without intravenous (I.V.) contrast material injection is considered sufficient for the diagnosis of spondyloarthritis (SpA), according to the Assessment of SpondyloArthritis International Society (ASAS) criteria. This work shows t...

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Bibliographic Details
Published in:Radiologia medica Vol. 124; no. 11; pp. 1142 - 1150
Main Authors: Gentili, Francesco, Cantarini, Luca, Fabbroni, Marta, Nigri, Aandrea, Mazzei, Francesco Giuseppe, Frediani, Bruno, Galeazzi, Mauro, Volterrani, Luca, Mazzei, Maria Antonietta
Format: Journal Article
Language:English
Published: Milan Springer Milan 01-11-2019
Springer Nature B.V
Subjects:
Arthritis
Bone marrow
Contrast agents
Contrast media
Diagnosis
Diagnostic Radiology
Evaluation
Imaging
Interventional Radiology
Joints (anatomy)
Magnetic Resonance Imaging
Medical imaging
Medicine
Medicine & Public Health
Neuroradiology
NMR
Nuclear magnetic resonance
Radiology
Statistical significance
Statistical tests
Therapy
Tumor necrosis factor-TNF
Ultrasound
Magnetic resonance imaging
Sacroiliitis
Treatment effects
Spondyloarthritis
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Summary:Object Active sacroiliitis based on magnetic resonance imaging (MRI) without intravenous (I.V.) contrast material injection is considered sufficient for the diagnosis of spondyloarthritis (SpA), according to the Assessment of SpondyloArthritis International Society (ASAS) criteria. This work shows the added value of administering I.V. contrast material when evaluating the response to tumor necrosis factor (TNF) antagonists therapy, on the extension of bone marrow oedema (BMO) and pathological enhancement (osteitis/synovitis) in the sacroiliac joints (SIJs) on MRI. Materials and methods Forty-three patients (25 females and 18 males, mean age of 54 ± 16.60 years, range 22–75 years) with a clinical diagnosis of SpA and active sacroiliitis at MRI with I.V. contrast material, were considered for a follow-up MRI after 6 months of TNF antagonists therapy. Disease activity was monitored by a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questionnaire. Descriptive statistics, Student’s t test and Cohen’s kappa were used. P  < 0.05 was considered statistically significant. Results Thirty-eight patients were finally included in the study; 36 of them showed an improvement on clinical assessment after therapy. Score’s difference (improvement) after treatment was calculated in the MRI sequences both with and without contrast agent (respectively, mean value and range 3.18, 0–12 with contrast and 1.63, 0–7 without contrast). This improvement was statistically significant in each group ( P value of 7.097e−08 with contrast and 6.741e−06 without contrast), and there was a significant difference between the two group too ( P -value of 8.598e−07). Cohen’s kappa for dichotomous variables showed a better agreement between the post-contrast MRI findings and BASDAI ( K  = 0.53, agreement = 92.11%, P  = 0.0001) than MRI without contrast and BASDAI ( K  = 0.11, agreement = 57.89%, P  = 0.06). Conclusions The evaluation of enhancement is a reliable tool for the assessment of the response to therapy in SIJs involvement in SpA, better than BMO; hence, it should be advised in the MRI of these patients.
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ISSN:0033-8362
1826-6983
DOI:10.1007/s11547-019-01016-w