Search Results - "Nigg, Alex L"

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease by Sepe, Sara, Milanese, Chiara, Gabriels, Sylvia, Derks, Kasper W.J., Payan-Gomez, Cesar, van IJcken, Wilfred F.J., Rijksen, Yvonne M.A., Nigg, Alex L., Moreno, Sandra, Cerri, Silvia, Blandini, Fabio, Hoeijmakers, Jan H.J., Mastroberardino, Pier G.

“…The underlying relation between Parkinson’s disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link…”
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Differentiating Cerebellar Impact on Thalamic Nuclei by Gornati, Simona V., Schäfer, Carmen B., Eelkman Rooda, Oscar H.J., Nigg, Alex L., De Zeeuw, Chris I., Hoebeek, Freek E.

“…The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical…”
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Compartmentalization of androgen receptors at endogenous genes in living cells by Yavuz, Selçuk, Kabbech, Hélène, van Staalduinen, Jente, Linder, Simon, van Cappellen, Wiggert A, Nigg, Alex L, Abraham, Tsion E, Slotman, Johan A, Quevedo, Marti, Poot, Raymond A, Zwart, Wilbert, van Royen, Martin E, Grosveld, Frank G, Smal, Ihor, Houtsmuller, Adriaan B

“…Abstract A wide range of nuclear proteins are involved in the spatio-temporal organization of the genome through diverse biological processes such as gene…”
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Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth by Morhayim, Jess, Peppel, Jeroen, Demmers, Jeroen A. A., Kocer, Gulistan, Nigg, Alex L., Driel, Marjolein, Chiba, Hideki, Leeuwen, Johannes P.

“…Beyond forming bone, osteoblasts play pivotal roles in various biologic processes, including hematopoiesis and bone metastasis. Extracellular vesicles (EVs)…”
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Growth factor dependent changes in nanoscale architecture of focal adhesions by Legerstee, Karin, Abraham, Tsion E., van Cappellen, Wiggert A., Nigg, Alex L., Slotman, Johan A., Houtsmuller, Adriaan B.

“…Focal adhesions (FAs) are flat elongated structures that mediate cell migration and link the cytoskeleton to the extracellular matrix. Along the vertical axis…”
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Impact of early- and late-onset preeclampsia on features of placental and newborn vascular health by Herzog, Emilie M, Eggink, Alex J, Reijnierse, Anniek, Kerkhof, Martina A.M, de Krijger, Ronald R, Roks, Anton J.M, Reiss, Irwin K.M, Nigg, Alex L, Eilers, Paul H.C, Steegers, Eric A.P, Steegers-Theunissen, Régine P.M

“…Abstract Introduction Offspring exposed to preeclampsia (PE) show an increased risk of cardiovascular disease in adulthood. We hypothesize that this is…”
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The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs by Stabile, Roberto, Cabezas, Mario Román, Verhagen, Mathijs P., Tucci, Francesco A., van den Bosch, Thierry P. P., De Herdt, Maria J., van der Steen, Berdine, Nigg, Alex L., Chen, Meng, Ivan, Cristina, Shimizu, Masayoshi, Koljenović, Senada, Hardillo, Jose A., Verrijzer, C. Peter, Baatenburg de Jong, Robert J., Calin, George A., Fodde, Riccardo

“…Cyclin-dependent kinase 2-associated protein 1 ( CDK2AP1 ; also known as deleted in oral cancer or DOC1 ) is a tumor suppressor gene known to play functional…”
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Identifying Molecular Changes in Early Cervical Cancer Samples of Patients That Developed Metastasis by de Geus, Vera, Ewing-Graham, Patricia C, de Koning, Willem, de Koning, Maurits N C, van den Bosch, Thierry P P, Nigg, Alex L, van Eijck, Casper H J, Jozwiak, Marta, van Beekhuizen, Heleen J, Mustafa, Dana A M

“…Cervical cancer is one of the most common cancers in women worldwide. Patients diagnosed with early-stage cervical cancer have a good prognosis, however,…”
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Compartmentalization of androgen receptor protein-protein interactions in living cells by van Royen, Martin E, Cunha, Sónia M, Brink, Maartje C, Mattern, Karin A, Nigg, Alex L, Dubbink, Hendrikus J, Verschure, Pernette J, Trapman, Jan, Houtsmuller, Adriaan B

“…Steroid receptors regulate gene expression in a ligand-dependent manner by binding specific DNA sequences. Ligand binding also changes the conformation of the…”
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Rapid Switching of TFIIH between RNA Polymerase I and II Transcription and DNA Repair In Vivo by Hoogstraten, Deborah, Nigg, Alex L, Heath, Helen, Mullenders, Leon H.F, van Driel, Roel, Hoeijmakers, Jan H.J, Vermeulen, Wim, Houtsmuller, Adriaan B

“…The transcription/repair factor TFIIH operates as a DNA helix opener in RNA polymerase II (RNAP2) transcription and nucleotide excision repair. To study TFIIH…”
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Action of DNA Repair Endonuclease ERCC1/XPF in Living Cells by Houtsmuller, Adriaan B., Rademakers, Suzanne, Nigg, Alex L., Hoogstraten, Deborah, Jan H. J. Hoeijmakers, Vermeulen, Wim

“…To study the nuclear organization and dynamics of nucleotide excision repair (NER), the endonuclease ERCC1/XPF (for excision repair cross complementation group…”
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Immunomics of Renal Allograft Acute T Cell-Mediated Rejection Biopsies of Tacrolimus- and Belatacept-Treated Patients by van der Zwan, Marieke, Baan, Carla C., Colvin, Robert B., Smith, Rex N., White, Rebecca A., Ndishabandi, Dorothy, Nigg, Alex L., van den Bosch, Thierry P.P., de Graav, Gretchen N., Clahsen-van Groningen, Marian C., Hesselink, Dennis A.

“…Belatacept-based therapy in kidney transplant recipient has been shown to increase long-term renal allograft and patient survival compared with calcineurin…”
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Dynamics of Protein Binding to Telomeres in Living Cells: Implications for Telomere Structure and Function by Mattern, Karin A., Swiggers, Susan J. J., Nigg, Alex L., Löwenberg, Bob, Houtsmuller, Adriaan B., Zijlmans, J. Mark J. M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression by Mustafa, Dana A. M., Pedrosa, Rute M. S. M., Smid, Marcel, van der Weiden, Marcel, de Weerd, Vanja, Nigg, Alex L., Berrevoets, Cor, Zeneyedpour, Lona, Priego, Neibla, Valiente, Manuel, Luider, Theo M., Debets, Reno, Martens, John W. M., Foekens, John A., Sieuwerts, Anieta M., Kros, Johan M.

“…The discovery of genes and molecular pathways involved in the formation of brain metastasis would direct the development of therapeutic strategies to prevent…”
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Prognostic value of intra‐tumoral CD8+/FoxP3+ lymphocyte ratio in patients with resected colorectal cancer liver metastasis by Sideras, Kostandinos, Galjart, Boris, Vasaturo, Angela, Pedroza‐Gonzalez, Alexander, Biermann, Katharina, Mancham, Shanta, Nigg, Alex L., Hansen, Bettina E., Stoop, Hans A., Zhou, Guoying, Verhoef, Cornelis, Sleijfer, Stefan, Sprengers, Dave, Kwekkeboom, Jaap, Bruno, Marco J.

“…Background and Objectives Patients with isolated colorectal‐cancer‐liver‐metastases (CRCLM) frequently undergo metastatectomy. Tumor‐infiltrating‐lymphocytes…”
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Xeroderma Pigmentosum Group A Protein Loads as a Separate Factor onto DNA Lesions by Rademakers, Suzanne, Volker, Marcel, Hoogstraten, Deborah, Nigg, Alex L., Moné, Martijn J., van Zeeland, Albert A., Hoeijmakers, Jan H. J., Houtsmuller, Adriaan B., Vermeulen, Wim

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cytokine production induced by binding and processing of calcium oxalate crystals in cultured macrophages by de Water, Ruud, Leenen, Pieter J.M., Noordermeer, Cindy, Nigg, Alex L., Houtsmuller, Adriaan B., Kok, Dirk J., Schr[ouml ]der, Fritz H.

“…Deposition of calcium oxalate (CaOx) crystals in the renal interstitium is common in humans with primary oxalosis and secondary hyperoxaluria, as well as in…”
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Association of TIMP3 expression with vessel density, macrophage infiltration and prognosis in human malignant melanoma by Das, Asha M, Koljenović, Senada, Oude Ophuis, Charlotte M.C, van der Klok, Thom, Galjart, Boris, Nigg, Alex L, van Cappellen, Wiggert A, Noordhoek Hegt, Vincent, Dinjens, Winand N.M, Atmodimedjo, Peggy N, Vermeulen, Cindy E, Verhoef, Cornelis, Eggermont, Alexander M.M, ten Hagen, Timo L.M

“…Abstract Aims Several anti-tumour properties have been ascribed to the tissue inhibitor of matrix metalloproteinases-3 (TIMP3) gene, including inhibition of…”
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Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage by Essers, Jeroen, Houtsmuller, Adriaan B., van Veelen, Lieneke, Paulusma, Coen, Nigg, Alex L., Pastink, Albert, Vermeulen, Wim, Hoeijmakers, Jan H.J., Kanaar, Roland

“…Recombination between homologous DNA molecules is essential for the proper maintenance and duplication of the genome, and for the repair of exogenously induced…”
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Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair by Gourdin, Audrey M., van Cuijk, Loes, Tresini, Maria, Luijsterburg, Martijn S., Nigg, Alex L., Giglia-Mari, Guiseppina, Houtsmuller, Adriaan B., Vermeulen, Wim, Marteijn, Jurgen A.

“…•Unlike RFC and PCNA, RPA does not cluster in replication foci in living cells.•RPA has differential dynamics during replication and the different steps of…”
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