Search Results - "Nigade, Prashant B"

Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282 by Verma, Mahip K., Samant, Charudatt, Kale, Ramesh, Patra, Sukanya, Mahajan, Nilesh, Gholve, Milind K., Marisetti, Ajitkumar, Sunkara, Brahmam, Naik, Aditya, Shingare, Manisha, Reddy, Madhusudhan, Bokare, Anand M., Akarte, Atul, Koul, Sarita, Nigade, Prashant B., Patil, Vinod B., Modi, Dipak, Ahirrao, Prajakta, Pawar, Shashikant, Kuldharan, Sandip, Dinchhana, Lal, Mehta, Maneesh, Gundu, Jayasagar, Jana, Nirmal, Vidhate, Prashant, Mahangare, Sachin Jaysing, Shukla, Manojkumar R., Goel, Rajan N., Bhonde, Mandar, Kamboj, Rajender Kumar, Palle, Venkata P.

“…Phosphoinositide 3-kinase (PI3K) pathway mediates key signaling events downstream to B-cell receptor (BCR) for survival of mature B-cells, and overexpression…”
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Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms by Nigade, Prashant B, Gundu, Jayasagar, Pai, K Sreedhara, Nemmani, Kumar V S, Talwar, Rashmi

“…The present study was aimed at developing simplified physiologically based semi-mechanistic algorithms to predict V and interspecies scaling factors to predict…”
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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzene­sulfonamide]: Structure–Activity Relationship and Preclinical Characterization by Sinha, Neelima, Karche, Navnath P, Verma, Mahip Kalyan, Walunj, Sameer S, Nigade, Prashant B, Jana, Gourhari, Kurhade, Sanjay P, Hajare, Anil K, Tilekar, Ajay R, Jadhav, Ganesh R, Thube, Baban R, Shaikh, Javed S, Balgude, Sudhakar, Singh, Lairikyengbam Bikramjit, Mahimane, Vijaya, Adurkar, Shridhar K, Hatnapure, Girish, Raje, Firoj, Bhosale, Yogesh, Bhanage, Dnyaneshwar, Sachchidanand, Sachchidanand, Dixit, Ruchi, Gupta, Rajesh, Bokare, Anand M, Dandekar, Manoj, Bharne, Ashish, Chatterjee, Manavi, Desai, Sagar, Koul, Sarita, Modi, Dipak, Mehta, Maneesh, Patil, Vinod, Singh, Minakshi, Gundu, Jayasagar, Goel, Rajan N, Shah, Chirag, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P

“…The discovery of a series of thiophenephenyl­sulfonamides as positive allosteric modulators (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR) is…”
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LL-00066471, a novel positive allosteric modulator of α7 nicotinic acetylcholine receptor ameliorates cognitive and sensorimotor gating deficits in animal models: Discovery and preclinical characterization by Verma, Mahip K., Goel, Rajan N., Bokare, Anand M., Dandekar, Manoj P., Koul, Sarita, Desai, Sagar, Tota, Santoshkumar, Singh, Nilendra, Nigade, Prashant B., Patil, Vinod B., Modi, Dipak, Mehta, Maneesh, Gundu, Jayasagar, Walunj, Sameer S., Karche, Navnath P., Sinha, Neelima, Kamboj, Rajender K., Palle, Venkata P.

“…α7 nicotinic acetylcholine receptor (α7 nAChR) is an extensively validated target for several neurological and psychiatric conditions namely, dementia and…”
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Discovery of Potent, Selective, and State-Dependent Na V 1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure-Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides by Ramdas, Vidya, Talwar, Rashmi, Kanoje, Vijay, Loriya, Rajesh M, Banerjee, Moloy, Patil, Pradeep, Joshi, Advait Arun, Datrange, Laxmikant, Das, Amit Kumar, Walke, Deepak Sahebrao, Kalhapure, Vaibhav, Khan, Talha, Gote, Ganesh, Dhayagude, Usha, Deshpande, Shreyas, Shaikh, Javed, Chaure, Ganesh, Pal, Ravindra R, Parkale, Santosh, Suravase, Sachin, Bhoskar, Smita, Gupta, Rajesh V, Kalia, Anil, Yeshodharan, Rajesh, Azhar, Mahammad, Daler, Jagadeesh, Mali, Vinod, Sharma, Geetika, Kishore, Amitesh, Vyawahare, Rupali, Agarwal, Gautam, Pareek, Himani, Budhe, Sagar, Nayak, Arun, Warude, Dnyaneshwar, Gupta, Praveen Kumar, Joshi, Parag, Joshi, Sneha, Darekar, Sagar, Pandey, Dilip, Wagh, Akshaya, Nigade, Prashant B, Mehta, Maneesh, Patil, Vinod, Modi, Dipak, Pawar, Shashikant, Verma, Mahip, Singh, Minakshi, Das, Sudipto, Gundu, Jayasagar, Nemmani, Kumar, Bock, Mark G, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P

“…Voltage-gated sodium channel Na 1.7 is a genetically validated target for pain. Identification of Na 1.7 inhibitors with all of the desired properties to…”
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Prediction of Tissue-to-Plasma Ratios of Basic Compounds in Mice by Nigade, Prashant B., Gundu, Jayasagar, Sreedhara Pai, K., Nemmani, Kumar V. S.

“…Background Majority of reported studies so far developed correlation regression equations using the rat muscle-to-plasma drug concentration ratio (Kp-muscle)…”
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Prediction of Tumor-to-Plasma Ratios of Basic Compounds in Subcutaneous Xenograft Mouse Models by Nigade, Prashant B., Gundu, Jayasagar, Pai, K. Sreedhara, Nemmani, Kumar V. S.

“…Background Predicting target site drug concentrations is of key importance for rank ordering compounds before proceeding to chronic pharmacodynamic models. We…”
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Cardioprotective effect of Azadirachta indica A. Juss. on isoprenaline induced myocardial infarction in rats by Peer, Prashee A, Trivedi, Purvi C, Nigade, Prashant B, Ghaisas, Mahesh M, Deshpande, Avinash D

“…Abstract The present study was designed to evaluate the cardioprotective potential of aqueous leaf extract of Azadirachta indica A. Juss. (AI) on the basis of…”
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Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization by Karche, Navnath P., Bhonde, Mandar, Sinha, Neelima, Jana, Gourhari, Kukreja, Gagan, Kurhade, Sanjay P., Jagdale, Arun R., Tilekar, Ajay R., Hajare, Anil K., Jadhav, Ganesh R., Gupta, Nishant R., Limaye, Rohan, Khedkar, Nilesh, Thube, Baban R., Shaikh, Javed S., Rao Irlapati, Nageswara, Phukan, Samiron, Gole, Gopal, Bommakanti, Apparao, Khanwalkar, Harshal, Pawar, Yogesh, Kale, Ramesh, Kumar, Rakesh, Gupta, Rajesh, Praveen Kumar, V.R., Wahid, Saif, Francis, Albi, Bhat, Tariq, Kamble, Nivrutti, Patil, Vinod, Nigade, Prashant B., Modi, Dipak, Pawar, Shashikant, Naidu, Sneha, Volam, Harish, Pagdala, Vamsi, Mallurwar, Sadanand, Goyal, Hemant, Bora, Pushpak, Ahirrao, Prajakta, Singh, Minakshi, Kamalakannan, Prabhakaran, Naik, Kumar Ram, Kumar, Pradipta, Powar, Rajendra G., Shankar, Rajesh B., Bernstein, Peter R., Gundu, Jayasagar, Nemmani, Kumar, Narasimham, Lakshmi, George, Kochumalayil Shaji, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P.

“…[Display omitted] The exploitation of GLU988 and LYS903 residues in PARP1 as targets to design isoquinolinone (I & II) and naphthyridinone (III) analogues is…”
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