The Rochester Protocol for Living Donor Liver Transplantation of Unresectable Colorectal Liver Metastasis: A 5-Year Report on Selection, Approval, and Outcomes

The Rochester Protocol for Living Donor Liver Transplantation of Unresectable Colorectal Liver Metastasis: A 5-Year Report on Selection, Approval, and Outcomes

Living donor liver transplantation (LDLT) is a treatment option for select patients with unresectable colorectal liver metastasis. We describe our center’s experience of patient selection, insurance approval, and outcomes after LDLT after first referral in March 2019. Of the 206 evaluated patients,...

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Bibliographic Details
Published in:American journal of transplantation
Main Authors: Byrne, Matthew M., Chávez-Villa, Mariana, Ruffolo, Luis I., Loria, Anthony, Endo, Yutaka, Niewiemski, Amber, Jimenez-Soto, Cristina, Melaragno, Jennifer I., Ramaraju, Gopal A., Farooq, Priya D., Dunne, Richard F., Pineda-Solis, Karen, Nair, Amit, Orloff, Mark, Tomiyama, Koji, Hernandez-Alejandro, Roberto
Format: Journal Article
Language:English
Published: United States Elsevier Inc 25-09-2024
Subjects:
colorectal liver metastasis
insurance approval
living donor liver transplant
selection criteria
surgical innovation
transplant oncology
LDLT
OS
surgical innovation
LT
transplant oncology
insurance approval
colorectal liver metastasis
CRC
uCRLM
SECA
selection criteria
living donor liver transplant
CEA
RFS
Transplant oncology
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Summary:Living donor liver transplantation (LDLT) is a treatment option for select patients with unresectable colorectal liver metastasis. We describe our center’s experience of patient selection, insurance approval, and outcomes after LDLT after first referral in March 2019. Of the 206 evaluated patients, 23 underwent LDLT. We found that patients who were referred earlier in their oncologic course were more likely to be eligible for transplantation. After completion of the Rochester Protocol for LDLT eligibility, recipients had a median delay of care of 10 days (IQR, 0-36 days) related to insurance appeal, with 6 patients (30%) having a delay longer than 30 days. LDLT recipients had an overall survival proportion of 100% and 91% at 1 and 3 years and a recurrence-free survival proportion of 100% and 40% at 1 and 3 years, respectively. All donors underwent right hepatectomy, of which only 1 donor had a Clavien-Dindo IIIa complication and readmission. There was no donor mortality. We assert that multidisciplinary care and strict patient selection through the Rochester Protocol were paramount to our center’s success. In the appropriately selected patient, LDLT for unresectable colorectal liver metastasis may be justified, and patients should be referred to transplant oncology centers for evaluation.
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ISSN:1600-6135
1600-6143
1600-6143
DOI:10.1016/j.ajt.2024.09.027