Magnesium stable isotope composition, but not concentration, responds to obesity and early insulin-resistant conditions in minipig

Magnesium stable isotope composition, but not concentration, responds to obesity and early insulin-resistant conditions in minipig

Hypomagnesemia is frequently associated with type 2 diabetes and generally correlates with unfavorable disease progression, but the magnesium status in pre-diabetic conditions remains unclear. Here, the magnesium metabolism is scrutinized in a minipig model of obesity and insulin resistance by measu...

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Bibliographic Details
Published in:Scientific reports Vol. 12; no. 1; p. 10941
Main Authors: le Goff, Samuel, Godin, Jean-Philippe, Albalat, Emmanuelle, Nieves, José Manuel Ramos, Balter, Vincent
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 29-06-2022
Nature Publishing Group
Nature Portfolio
Subjects:
631/45/321/1158
692/163/2743/137
704/158/2466
Diabetes
Diabetes mellitus (non-insulin dependent)
Humanities and Social Sciences
Hypomagnesemia
Insulin
Insulin resistance
Insulin secretion
Isotopes
Lipoproteins
Liver
Magnesium
multidisciplinary
Obesity
Phenotypes
Science
Science (multidisciplinary)
Stable isotopes
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Summary:Hypomagnesemia is frequently associated with type 2 diabetes and generally correlates with unfavorable disease progression, but the magnesium status in pre-diabetic conditions remains unclear. Here, the magnesium metabolism is scrutinized in a minipig model of obesity and insulin resistance by measuring variations of the metallome—the set of inorganic elements—and the magnesium stable isotope composition in six organs of lean and obese minipigs raised on normal and Western-type diet, respectively. We found that metallomic variations are most generally insensitive to lean or obese phenotypes. The magnesium stable isotope composition of plasma, liver, kidney, and heart in lean minipigs are significantly heavier than in obese minipigs. For both lean and obese minipigs, the magnesium isotope composition of plasma and liver were negatively correlated to clinical phenotypes and plasma lipoproteins concentration as well as positively correlated to hyperinsulinemic-euglycemic clamp output. Because the magnesium isotope composition was not associated to insulin secretion, our results suggest that it is rather sensitive to whole body insulin sensitivity, opening perspectives to better comprehend the onset of insulin-resistant diabetic conditions.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-14825-3