Search Results - "Nieuwenhuizen, WF"

Is Candida albicans a trigger in the onset of coeliac disease? by Nieuwenhuizen, WF, Pieters, RHH, Knippels, LMJ, Jansen, MCJF, Koppelman, SJ

“…Coeliac disease is a T-cell-mediated autoimmune disease of the small intestine that is induced by ingestion of gluten proteins from wheat, barley, or rye. We…”
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Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine by Peschel, A, Jack, R W, Otto, M, Collins, L V, Staubitz, P, Nicholson, G, Kalbacher, H, Nieuwenhuizen, W F, Jung, G, Tarkowski, A, van Kessel, K P, van Strijp, J A

“…Defensins, antimicrobial peptides of the innate immune system, protect human mucosal epithelia and skin against microbial infections and are produced in large…”
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A novel and sensitive method for the detection of T cell stimulatory epitopes of α/β- and γ-gliadin by Spaenij-Dekking, E H A, Kooy-Winkelaar, E M C, Nieuwenhuizen, W F, Drijfhout, J W, Koning, F

“…Background: It is now generally accepted that coeliac disease (CD) is caused by inflammatory T cell responses to gluten peptides bound to HLA-DQ2 or -DQ8…”
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Reversible Denaturation of Brazil Nut 2S Albumin (Ber e1) and Implication of Structural Destabilization on Digestion by Pepsin by Koppelman, Stef J, Nieuwenhuizen, Willem F, Gaspari, Marco, Knippels, Leon M. J, Penninks, André H, Knol, Edward F, Hefle, Susan L, de Jongh, Harmen H. J

“…The high resistance of Brazil nut 2S albumin, previously identified as an allergen, against proteolysis by pepsin was examined in this work. Although the…”
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Modification of Glutamine and Lysine Residues in Holo and Apo α-Lactalbumin with Microbial Transglutaminase by Nieuwenhuizen, Willem F, Dekker, Henk L, de Koning, Leo J, Gröneveld, Toos, de Koster, Chris G, de Jong, Govardus A. H

“…The molecular structures determine the physical properties of milk proteins and are important for the texture of many dairy-based foods. Bovine α-lactalbumin…”
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Structure-function relationships in the tryptophan-rich, antimicrobial peptide indolicidin by Staubitz, Petra, Peschel, Andreas, Nieuwenhuizen, Willem F., Otto, Michael, Götz, Friedrich, Jung, Günther, Jack, Ralph W.

“…Indolicidin is a cationic 13 amino acid peptide amide produced in the granules of bovine neutrophils with the sequence H‐ILPWKWPWWPWRR‐NH2. Indolicidin is both…”
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Transglutaminase-mediated modification of glutamine and lysine residues in native bovine beta-lactoglobulin by Nieuwenhuizen, W.F, Dekker, H.L, Groneveld, T, Koster, C.G. de, Jong, G.A.H. de

“…Bovine beta-lactoglobulin (BLG) is a major component in whey and its physical properties are important for the texture of many dairy-based foods. Modification…”
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Synthesis of a novel fluorescent ceramide analogue and its use in the characterization of recombinant ceramidase from Pseudomonas aeruginosa PA01 by Nieuwenhuizen, Willem F, Leeuwen, Sander van, Götz, Friedrich, Egmond, Maarten R

“…Ceramidase (CDase) hydrolyses the N-acyl linkage of the sphingolipid ceramide. We synthesized the non-fluorescent ceramide analogue (4 E,2 S,3 R)-2-…”
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Molecular cloning and characterization of the alkaline ceramidase from Pseudomonas aeruginosa PA01 by Nieuwenhuizen, Willem F, van Leeuwen, Sander, Jack, Ralph W, Egmond, Maarten R, Götz, Friedrich

“…Ceramidase (CDase) hydrolyzes the amide bond in ceramides to yield free fatty acid and sphingosine. From a 3-L Pseudomonas aeruginosa PA01 culture, 70 μg of…”
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Reduction of Acetylenic Compounds to (E)-Olefins by Alkali Metals - An Investigation of the Scope by Brandsma, Lambert, Nieuwenhuizen, Willem F., Zwikker, Jan W., Mäeorg, Uno

“…Efficient procedures have been developed for the stereospecific reduction by alkali metals of disubstituted acetylenes with long carbon chains. Acetylenes…”
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Dioxygenation of N-linoleoyl amides by soybean lipoxygenase-1 by van der Stelt, Marcelis, Nieuwenhuizen, Willem F, Veldink, Gerrit A, Vliegenthart, Johannes F.G

“…Anandamide, a novel neurotransmitter, has been reported to be dioxygenated by brain lipoxygenase [1, 11]. Anandamides constitute a new class of neuroregulatory…”
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The effect of hydroxylation of linoleoyl amides on their cannabinomimetic properties by van der Stelt, Marcelis, Paoletti, Anna Maria, Maccarrone, Mauro, Nieuwenhuizen, Willem F, Bagetta, Giacinto, Veldink, Gerrit A, Finazzi Agrò, Alessandro, Vliegenthart, Johannes F.G

“…As yet, the physiological significance of hydroxylation of anandamide and linoleoyl amides is unknown. Therefore, we investigated whether hydroxylation of…”
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Lipoxygenase Is Irreversibly Inactivated by the Hydroperoxides Formed from the Enynoic Analogues of Linoleic Acid by Nieuwenhuizen, Willem F, Van der Kerk-Van Hoof, Anca, van Lenthe, Joop H, Van Schaik, Rene C, Versluis, Kees, Veldink, Gerrit A, Vliegenthart, Johannes F. G

“…Triple bond analogues of natural fatty acids irreversibly inactivate lipoxygenase during their enzymatic conversion [Nieuwenhuizen, W. F., et al. (1995)…”
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Mechanism of Lipoxygenase Inactivation by the Linoleic Acid Analogue Octadeca-9,12-diynoic Acid by Schilstra, Maria J, Nieuwenhuizen, Willem F, Veldink, Gerrit A, Vliegenthart, Johannes F. G

“…During the irreversible inactivation of soybean Fe(III)-lipoxygenase [Fe(III)-LOX] by octadeca-9,12-diynoic acid (ODYA), significant quantities of…”
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Fe(III)-Lipoxygenase Converts Its Suicide-Type Inhibitor Octadeca-9,12-diynoic Acid into 11-Oxooctadeca-9,12-diynoic Acid by Nieuwenhuizen, Willem F, Schilstra, Maria J, Van der Kerk-Van Hoof, Anca, Brandsma, Lambert, Veldink, Gerrit A, Vliegenthart, Johannes F. G

“…Triple bond analogues of polyunsaturated fatty acids irreversibly inactivate lipoxygenases. During the inactivation the inhibitors are converted enzymatically…”
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Chemical and Quantum Mechanical Studies of the Free Radical C-C Bond Formation in the Lipoxygenase-Catalyzed Dimerisation of Octadeca-9,12-Diynoic Acid by Nieuwenhuizen, Willem F, van Lenthe, Joop H, Blomsma, Erwin J, Van der Kerk-Van Hoof, Anca C, Veldink, Gerrit A, Vliegenthart, Johannes F.G

“…Triple bond analogues of poly-unsaturated fatty acids are well-known inactivators of lipoxygenases. In an earlier study we proposed that, since…”
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Membrane modifications in human erythroleukemia K562 cells during induction of programmed cell death by transforming growth factor beta 1 or cisplatin by Maccarrone, M, Nieuwenhuizen, W E, Dullens, H F, Catani, M V, Melino, G, Veldink, G A, Vliegenthart, J F, Finazzo Agrò, A

“…Transforming growth factor beta 1 (TGF beta 1) and cisplatin induce apoptosis (programmed cell death, PCD) in human erythroleukemia K562 cells in an additive…”
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