Search Results - "Nieuwenhoven, Frans A."

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion by Blythe, Nicola M., Muraki, Katsuhiko, Ludlow, Melanie J., Stylianidis, Vasili, Gilbert, Hamish T.J., Evans, Elizabeth L., Cuthbertson, Kevin, Foster, Richard, Swift, Joe, Li, Jing, Drinkhill, Mark J., van Nieuwenhoven, Frans A., Porter, Karen E., Beech, David J., Turner, Neil A.

“…Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its role in the heart is poorly understood. Cardiac fibroblasts…”
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MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload–Induced Heart Failure by Verjans, Robin, Peters, Tim, Beaumont, Francisco Javier, van Leeuwen, Rick, van Herwaarden, Tessa, Verhesen, Wouter, Munts, Chantal, Bijnen, Mitchell, Henkens, Michiel, Diez, Javier, de Windt, Leon J, van Nieuwenhoven, Frans A, van Bilsen, Marc, Goumans, Marie José, Heymans, Stephane, González, Arantxa, Schroen, Blanche

“…Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to increased interstitial fibrosis formation and subsequently…”
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The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction by van Nieuwenhoven, Frans A, Turner, Neil A

“…Abstract Cardiac fibroblasts (CF) play a pivotal role in the repair and remodeling of the heart that occur following myocardial infarction (MI). The transition…”
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The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy by Kuiper, Esther J, Van Nieuwenhoven, Frans A, de Smet, Marc D, van Meurs, Jan C, Tanck, Michael W, Oliver, Noelynn, Klaassen, Ingeborg, Van Noorden, Cornelis J F, Goldschmeding, Roel, Schlingemann, Reinier O

“…In proliferative diabetic retinopathy (PDR), vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) cause blindness by…”
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Culturing of Cardiac Fibroblasts in Engineered Heart Matrix Reduces Myofibroblast Differentiation but Maintains Their Response to Cyclic Stretch and Transforming Growth Factor β1 by Ploeg, Meike C, Munts, Chantal, Seddiqi, Tayeba, ten Brink, Tim J. L, Breemhaar, Jonathan, Moroni, Lorenzo, Prinzen, Frits. W, van Nieuwenhoven, Frans. A

“…Isolation and culturing of cardiac fibroblasts (CF) induces rapid differentiation toward a myofibroblast phenotype, which is partly mediated by the high…”
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Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats by Daniels, Anneleen, Linz, Dominik, van Bilsen, Marc, Rütten, Hartmut, Sadowski, Thorsten, Ruf, Sven, Juretschke, Hans-Paul, Neumann-Haefelin, Claudia, Munts, Chantal, van der Vusse, Ger J., van Nieuwenhoven, Frans A.

“…Aims Type 2 diabetes mellitus (DM) leads to cardiac dysfunction irrespective of hypertension and coronary artery disease; this is called diabetic…”
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Left atrial remodeling in mitral regurgitation: A combined experimental-computational study by Bouwmeester, Sjoerd, van Loon, Tim, Ploeg, Meike, Mast, Thomas P, Verzaal, Nienke J, van Middendorp, Lars B, Strik, Marc, van Nieuwenhoven, Frans A, Dekker, Lukas R, Prinzen, Frits W, Lumens, Joost, Houthuizen, Patrick

“…Aims Progressive changes to left atrial (LA) structure and function following mitral regurgitation (MR) remain incompletely understood. This study aimed to…”
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Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis by Wang, Shujin, Schianchi, Francesco, Neumann, Dietbert, Wong, Li-Yen, Sun, Aomin, van Nieuwenhoven, Frans A., Zeegers, Maurice P., Strzelecka, Agnieszka, Col, Umare, Glatz, Jan F.C., Nabben, Miranda, Luiken, Joost J.F.P.

“…The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a…”
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The Complex Relation between Atrial Cardiomyopathy and Thrombogenesis by D’Alessandro, Elisa, Winters, Joris, van Nieuwenhoven, Frans A, Schotten, Ulrich, Verheule, Sander

“…Heart disease, as well as systemic metabolic alterations, can leave a ‘fingerprint’ of structural and functional changes in the atrial myocardium, leading to…”
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A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease by Koopsen, Tijmen, Van Osta, Nick, Van Loon, Tim, Van Nieuwenhoven, Frans A, Prinzen, Frits W, Van Klarenbosch, Bas R, Kirkels, Feddo P, Teske, Arco J, Vernooy, Kevin, Delhaas, Tammo, Lumens, Joost

“…Computational modeling of cardiac mechanics and hemodynamics in ischemic heart disease (IHD) is important for a better understanding of the complex relations…”
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CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy by NGUYEN, Tri Q, ROESTENBERG, Peggy, BRANDAN, Enrique, LYONS, Karen M, GOLDSCHMEDING, Roel, VAN NIEUWENHOVEN, Frans A, BOVENSCHEN, Niels, ZEKE LI, XU, Leon, OLIVER, Noelynn, ATEN, Jan, JOLES, Jaap A, VIAL, Cecilia

“…In diabetic nephropathy, connective tissue growth factor (CTGF) is upregulated and bone morphogenetic protein 7 (BMP-7) is downregulated. CTGF is known to…”
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Piezo1 Mechanosensitive Ion Channel Mediates Stretch-Induced Nppb Expression in Adult Rat Cardiac Fibroblasts by Ploeg, Meike C., Munts, Chantal, Prinzen, Frits W., Turner, Neil A., van Bilsen, Marc, van Nieuwenhoven, Frans A.

“…In response to stretch, cardiac tissue produces natriuretic peptides, which have been suggested to have beneficial effects in heart failure patients. In the…”
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Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay by D'Alessandro, Elisa, Scaf, Billy, van Oerle, René, van Nieuwenhoven, Frans A., van Hunnik, Arne, Verheule, Sander, Schotten, Ulrich, ten Cate, Hugo, Spronk, Henri M.H.

“…The goat model of atrial fibrillation (AF) allows investigation of the effect of AF on coagulation. However, assays for goat plasma are not available from…”
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Hypertension is a conditional factor for the development of cardiac hypertrophy in type 2 diabetic mice by van Bilsen, Marc, Daniels, Anneleen, Brouwers, Olaf, Janssen, Ben J A, Derks, Wouter J A, Brouns, Agnieszka E, Munts, Chantal, Schalkwijk, Casper G, van der Vusse, Ger J, van Nieuwenhoven, Frans A

“…Type 2 diabetes is frequently associated with co-morbidities, including hypertension. Here we investigated if hypertension is a critical factor in myocardial…”
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Local microRNA‐133a downregulation is associated with hypertrophy in the dyssynchronous heart by Middendorp, Lars B., Kuiper, Marion, Munts, Chantal, Wouters, Philippe, Maessen, Jos G., Nieuwenhoven, Frans A., Prinzen, Frits W.

“…Aims Left bundle branch block (LBBB) creates considerable regional differences in mechanical load within the left ventricle (LV). We investigated expression of…”
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Plasma Connective Tissue Growth Factor Is an Independent Predictor of End-Stage Renal Disease and Mortality in Type 1 Diabetic Nephropathy by NGUYEN, Tri Q, TARNOW, Lise, JORSAL, Anders, OLIVER, Noelynn, ROESTENBERG, Peggy, ITO, Yasuhiko, PARVING, Hans-Henrik, ROSSING, Peter, VAN NIEUWENHOVEN, Frans A, GOLDSCHMEDING, Roel

“…Plasma Connective Tissue Growth Factor Is an Independent Predictor of End-Stage Renal Disease and Mortality in Type 1 Diabetic Nephropathy Tri Q. Nguyen , MD 1…”
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CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress by Hall-Glenn, Faith, Aivazi, Armen, Akopyan, Lusi, Ong, Jessica R., Baxter, Ruth R., Benya, Paul D., Goldschmeding, Roel, van Nieuwenhoven, Frans A., Hunziker, Ernst B., Lyons, Karen M.

“…CCN2 (connective tissue growth factor (CTGF/CCN2)) is a matricellular protein that utilizes integrins to regulate cell proliferation, migration and survival…”
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Heat Shock Proteins and Cardiovascular Pathophysiology by Snoeckx, Luc H. E. H, Cornelussen, Richard N, Van Nieuwenhoven, Frans A, Reneman, Robert S, Van der Vusse, Ger J

“…Department of Physiology, Faculty of Medicine, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands Snoeckx, Luc…”
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Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1 by D'Alessandro, Elisa, Scaf, Billy, Munts, Chantal, van Hunnik, Arne, Trevelyan, Christopher J, Verheule, Sander, Spronk, Henri M H, Turner, Neil A, Ten Cate, Hugo, Schotten, Ulrich, van Nieuwenhoven, Frans A

“…Coagulation factor (F) Xa induces proinflammatory responses through activation of protease-activated receptors (PARs). However, the effect of FXa on cardiac…”
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Urinary Connective Tissue Growth Factor Excretion Correlates With Clinical Markers of Renal Disease in a Large Population of Type 1 Diabetic Patients With Diabetic Nephropathy by Nguyen, Tri Q, Tarnow, Lise, Andersen, Steen, Hovind, Peter, Parving, Hans-Henrik, Goldschmeding, Roel, van Nieuwenhoven, Frans A

“…OBJECTIVE:--Levels of connective tissue growth factor (CTGF; CCN-2) in plasma are increased in various fibrotic disorders, including diabetic nephropathy…”
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