Search Results - "Nieto, Steven"

Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder by Burnette, Elizabeth M., Nieto, Steven J., Grodin, Erica N., Meredith, Lindsay R., Hurley, Brian, Miotto, Karen, Gillis, Artha J., Ray, Lara A.

“…Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with only three widely-approved pharmacotherapies. Given that AUD is a…”
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Applying the Addictions Neuroclinical Assessment to derive neurofunctional domains in individuals who use methamphetamine by Nieto, Steven J., Ray, Lara A.

“…The Addictions Neuroclinical Assessment (ANA) was proposed as a neuroscience-informed clinical framework to understand heterogeneity in addiction encompassing…”
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Neural correlates of the addictions neuroclinical assessment (ANA) incentive salience factor among individuals with alcohol use disorder by Nieto, Steven J., Grodin, Erica N., Ray, Lara A.

“…The Addictions Neuroclinical Assessment (ANA) is a recently-developed framework offering a more holistic understanding of three neurofunctional and behavioral…”
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Cannabis use and subjective response to alcohol in the human laboratory by Nieto, Steven J., Venegas, Alexandra, Hudson, Jazzlyne, Ray, Lara A.

“…Cannabis is often used in combination with alcohol; yet, whether cannabis use impacts risk factors for alcohol use disorder (AUD) remains unknown. Subjective…”
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Translational models of addiction phenotypes to advance addiction pharmacotherapy by Ray, Lara A., Nieto, Steven J., Grodin, Erica N.

“…Alcohol and substance use disorders are heterogeneous conditions with limited effective treatment options. While there have been prior attempts to classify…”
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Leveraging meta-regression to test if medication effects on cue-induced craving are associated with clinical efficacy by Nieto, Steven J., Du, Han, Meredith, Lindsay R., Donato, Suzanna, Magill, Molly, Ray, Lara A.

“…Rationale The alcohol cue exposure paradigm is a common method for evaluating new treatments for alcohol use disorder (AUD); however, it is unclear if…”
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Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder by Kirsch, Dylan E, Grodin, Erica N, Nieto, Steven J, Kady, Annabel, Ray, Lara A

“…Early life stress (ELS) increases risk for psychiatric illness, including alcohol use disorder (AUD). Researchers have hypothesized that individuals with and…”
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Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study by Ray, Lara A., Nieto, Steven J., Meredith, Lindsay R., Burnette, Elizabeth, Donato, Suzanna, Magill, Molly, Du, Han

“…   Rationale Alcohol administration and cue-reactivity paradigms are frequently used to screen for the initial efficacy of medications for alcohol use disorder…”
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Evaluation of the Addictions Neuroclinical Assessment (ANA) framework through deep phenotyping of problem drinkers by Nieto, Steven J., Grodin, Erica N., Green, ReJoyce, Ray, Lara A.

“…•Independent evaluations of the Addictions Neuroclinical Assessment (ANA) are needed.•Latent factors were derived from a large sample of deeply phenotyped…”
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Who’s your daddy? Behavioral and epigenetic consequences of paternal drug exposure by Nieto, Steven J., Kosten, Therese A.

“…•Epigenetic studies involving paternal drug exposures are in their infancy.•Paternal drug exposure has long-lasting consequences in offspring.•Epigenetic…”
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Translational opportunities in animal and human models to study alcohol use disorder by Nieto, Steven J., Grodin, Erica N., Aguirre, Claudia G., Izquierdo, Alicia, Ray, Lara A.

“…Animal and human laboratory paradigms offer invaluable approaches to study the complex etiologies and mechanisms of alcohol use disorder (AUD). We contend that…”
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Paternal alcohol exposure has task‐ and sex‐dependent behavioral effect in offspring by Nieto, Steven J., Harding, Mark J., Nielsen, David A., Kosten, Therese A.

“…Background Endophenotypes for alcohol use disorder are well known and may reflect paternal exposure effects passed down to offspring via epigenetic mechanisms…”
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Combination treatment with varenicline and naltrexone reduces World Health Organization risk drinking levels by Nieto, Steven J., Enders, Craig K., Witkiewitz, Katie, O'Malley, Stephanie S., Ray, Lara A.

“…Background The U.S. Food and Drug Administration identifies abstinence and the absence of heavy drinking days as outcomes for pharmacotherapy trials for…”
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Reward, Relief and Habit Drinking: Initial Validation of a Brief Assessment Tool by Grodin, Erica N, Bujarski, Spencer, Venegas, Alexandra, Baskerville, Wave-Ananda, Nieto, Steven J, Jentsch, J David, Ray, Lara A

“…Abstract Aims Alcohol use disorder is highly heterogeneous. One approach to understanding this heterogeneity is the identification of drinker subtypes. A…”
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Female Sprague-Dawley rats display greater appetitive and consummatory responses to alcohol by Nieto, Steven J., Kosten, Therese A.

“…•Female rats show greater appetitive and consummatory behaviors than males.•Sex effect for appetitive alcohol behaviors is stronger than for sucrose.•Sex…”
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Lifetime heavy drinking years predict alcohol use disorder severity over and above current alcohol use by Nieto, Steven J., Baskerville, Wave, Donato, Suzanna, Bujarski, Spencer, Ray, Lara

“…Background: Preclinical studies demonstrate that chronic and heavy alcohol use facilitates neuroadaptations that perpetuate addiction-like behaviors. In…”
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A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial by Ray, Lara A., Baskerville, Wave-Ananda, Nieto, Steven J., Grodin, Erica, Enders, Craig, Kady, Annabel, Meredith, Lindsay, Gillis, Artha, Leventhal, Adam, Ho, Diana, Miotto, Karen

“…Rationale Screening novel medications for alcohol use disorder (AUD) requires models that are both efficient and ecologically-valid. Ideally, such models would…”
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Additive roles of tobacco and cannabis co-use in relation to delay discounting in a sample of heavy drinkers by Nieto, Steven J., Venegas, Alexandra, Burnette, Elizabeth M., MacKillop, James, Ray, Lara A.

“…Rationale Alcohol use disorder (AUD) is associated with steeper delay discounting rates; however, it is unknown whether substance co-use, particularly cannabis…”
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Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice by Iñiguez, Sergio D, Riggs, Lace M, Nieto, Steven J, Dayrit, Genesis, Zamora, Norma N, Shawhan, Kristi L, Cruz, Bryan, Warren, Brandon L

“…Abstract Exposure to stress is highly correlated with the emergence of mood-related illnesses. Because major depressive disorder often emerges in adolescence,…”
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Persistence of Operant Responding for Food After Prior Cocaine Exposure in Fischer 344 But Not Lewis Rats by Forouzan, Shadab, Nieto, Steven J., Kosten, Therese A.

“…Background and Objectives Chronic cocaine exposure has differential neural effects in Fischer 344 (F344) vs Lewis inbred rats that may explain strain‐dependent…”
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