Search Results - "Nieto, Pedro M"

STD-NMR: application to transient interactions between biomolecules—a quantitative approach by Angulo, Jesus, Nieto, Pedro M.

“…Saturation transfer difference NMR (STD NMR) spectroscopy is one of the most powerful NMR techniques for detection and characterization of transient (fast)…”
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Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates by Angulo, Jesús, Enríquez-Navas, Pedro M., Nieto, Pedro M.

“…The direct evaluation of dissociation constants (KD) from the variation of saturation transfer difference (STD) NMR spectroscopy values with the…”
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GAG Multivalent Systems to Interact with Langerin by Rojo, Javier, Nieto, Pedro M, de Paz, José L

“…Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a pivotal role protecting organisms against pathogen infections. To…”
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Synthesis of (1→3) Thiodisaccharides of GlcNAc and the Serendipitous Formation of 2,3-Dideoxy-(1→2)-thiodisaccharides through a Vinyl Azide Intermediate by Cristófalo, Alejandro Ezequiel, Nieto, Pedro M, Uhrig, María Laura

“…The syntheses of β-S-GlcA­(1→3)­GlcNAc and β-S-Gal­(1→3)­GlcNAc thiodisaccharides, which can be considered mimetics of the repeating units of hyaluronan and…”
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Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition by Porkolab, Vanessa, Chabrol, Eric, Varga, Norbert, Ordanini, Stefania, Sutkevičiu̅tė, Ieva, Thépaut, Michel, García-Jiménez, Maria José, Girard, Eric, Nieto, Pedro M, Bernardi, Anna, Fieschi, Franck

“…At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of carbohydrate-based PAMPS or DAMPS (pathogen- or danger-associated…”
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Fluorous-tag assisted synthesis of a glycosaminoglycan mimetic tetrasaccharide as a high-affinity FGF-2 and midkine ligand by Maza, Susana, Gandia-Aguado, Noel, de Paz, José L., Nieto, Pedro M.

“…[Display omitted] Here, we present the preparation of a sulfated, fully protected tetrasaccharide derivative following the glycosaminoglycan (GAG)-related…”
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Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments by Muñoz-García, Juan C, Chabrol, Eric, Vivès, Romain R, Thomas, Aline, de Paz, José L, Rojo, Javier, Imberty, Anne, Fieschi, Franck, Nieto, Pedro M, Angulo, Jesús

“…Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent…”
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The Use of NMR to Study Transient Carbohydrate-Protein Interactions by Nieto, Pedro M

“…Carbohydrates are biologically ubiquitous and are essential to the existence of all known living organisms. Although they are better known for their role as…”
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The Interaction between Chondroitin Sulfate and Dermatan Sulfate Tetrasaccharides and Pleiotrophin by García-Jiménez, María Jose, Torres-Rico, Myriam, de Paz, José L, Nieto, Pedro M

“…Pleiotrophin (PTN) is a neurotrophic factor that participates in the development of the embryonic central nervous system (CNS) and neural stem cell regulation…”
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Glycodendrimers as Chondroitin Sulfate Mimetics: Synthesis and Binding to Growth Factor Midkine by Domínguez‐Rodríguez, Pedro, Reina, José J., Gil‐Caballero, Sergio, Nieto, Pedro M., de Paz, José L., Rojo, Javier

“…Chondroitin sulfate (CS) is a member of the glycosaminoglycan (GAG) family, a class of polysaccharides implicated in relevant biological functions. The…”
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Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C‑type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design by Thépaut, Michel, Guzzi, Cinzia, Sutkeviciute, Ieva, Sattin, Sara, Ribeiro-Viana, Renato, Varga, Norbert, Chabrol, Eric, Rojo, Javier, Bernardi, Anna, Angulo, Jesus, Nieto, Pedro M, Fieschi, Franck

“…In genital mucosa, different fates are described for HIV according to the subtype of dendritic cells (DCs) involved in its recognition. This notably depends on…”
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Synthesis of a Fluorous-Tagged Hexasaccharide and Interaction with Growth Factors Using Sugar-Coated Microplates by Maza, Susana, de Paz, José L, Nieto, Pedro M

“…Here, we report the synthesis of a sulfated, fully protected hexasaccharide as a glycosaminoglycan mimetic and the study of its interactions with different…”
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Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics by Miles, Jonathan R, Wang, Xu, de Paz, Jose L, Nieto, Pedro M

“…Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution…”
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Synthesis of Chondroitin Sulfate Oligosaccharides Using N-(Tetrachlorophthaloyl)- and N-(Trifluoroacetyl)galactosamine Building Blocks by Macchione, Giuseppe, Maza, Susana, Mar Kayser, M., de Paz, José L., Nieto, Pedro M.

“…We have explored synthetic routes for the preparation of chondroitin sulfate (CS) oligosaccharides based on the use of N‐tetrachlorophthaloyl‐ (N‐TCP) and…”
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Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach by Macchione, Giuseppe, de Paz, José L., Nieto, Pedro M.

“…•We describe the synthesis of hyaluronic acid oligosaccharides.•Glucuronic acid units were employed in the glycosylation reactions.•A three-step deprotection…”
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Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides by Mena-Barragán, Teresa, de Paz, José L, Nieto, Pedro M

“…Here, we present an exploratory study on the fluorous-assisted synthesis of chondroitin sulfate (CS) oligosaccharides. Following this approach, a CS…”
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Effect of the Substituents of the Neighboring Ring in the Conformational Equilibrium of Iduronate in Heparin-like Trisaccharides by Muñoz-García, Juan Carlos, López-Prados, Javier, Angulo, Jesús, Díaz-Contreras, Irene, Reichardt, Niels, de Paz, José L., Martín-Lomas, Manuel, Nieto, Pedro M.

“…Based on the structure of the regular heparin, we have prepared a smart library of heparin‐like trisaccharides by incorporating some sulfate groups in the…”
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Experimental Measurement of Carbohydrate-Aromatic Stacking in Water by Using a Dangling-Ended DNA Model System by Morales, Juan C., Reina, José J., Díaz, Irene, Aviñó, Anna, Nieto, Pedro M., Eritja, Ramón

“…Protein–carbohydrate recognition is of fundamental importance for a large number of biological processes; carbohydrate–aromatic stacking is a widespread, but…”
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Saturation Transfer Difference (STD) NMR Spectroscopy Characterization of Dual Binding Mode of a Mannose Disaccharide to DC-SIGN by Angulo, Jesús, Díaz, Irene, Reina, José J, Tabarani, Georges, Fieschi, Franck, Rojo, Javier, Nieto, Pedro M

“…Concurrent multiple binding modes of a single ligand can be detected and quantified by saturation transfer difference (STD) NMR spectroscopy. Analysis of…”
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1,2-Mannobioside Mimic: Synthesis, DC-SIGN Interaction by NMR and Docking, and Antiviral Activity by Reina, José J., Sattin, Sara, Invernizzi, Donatella, Mari, Silvia, Martínez-Prats, Lorena, Tabarani, Georges, Fieschi, Franck, Delgado, Rafael, Nieto, Pedro M., Rojo, Javier, Bernardi, Anna

“…The design and preparation of carbohydrate ligands for DC‐SIGN is a topic of high interest because of the role played by this C‐type lectin in immunity and…”
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