Search Results - "Nieto, Pedro"

STD-NMR: application to transient interactions between biomolecules—a quantitative approach by Angulo, Jesus, Nieto, Pedro M.

“…Saturation transfer difference NMR (STD NMR) spectroscopy is one of the most powerful NMR techniques for detection and characterization of transient (fast)…”
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Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates by Angulo, Jesús, Enríquez-Navas, Pedro M., Nieto, Pedro M.

“…The direct evaluation of dissociation constants (KD) from the variation of saturation transfer difference (STD) NMR spectroscopy values with the…”
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Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition by Porkolab, Vanessa, Chabrol, Eric, Varga, Norbert, Ordanini, Stefania, Sutkevičiu̅tė, Ieva, Thépaut, Michel, García-Jiménez, Maria José, Girard, Eric, Nieto, Pedro M, Bernardi, Anna, Fieschi, Franck

“…At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of carbohydrate-based PAMPS or DAMPS (pathogen- or danger-associated…”
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Fluorous-Tag-Assisted Synthesis of GAG-Like Oligosaccharides by de Paz, José L, Nieto, Pedro M

“…The classic, solution-phase synthesis of glycosaminoglycan (GAG) oligosaccharides is hampered by the numerous, time-consuming chromatographic purifications…”
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GAG Multivalent Systems to Interact with Langerin by Rojo, Javier, Nieto, Pedro M, de Paz, José L

“…Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a pivotal role protecting organisms against pathogen infections. To…”
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Synthesis of (1→3) Thiodisaccharides of GlcNAc and the Serendipitous Formation of 2,3-Dideoxy-(1→2)-thiodisaccharides through a Vinyl Azide Intermediate by Cristófalo, Alejandro Ezequiel, Nieto, Pedro M, Uhrig, María Laura

“…The syntheses of β-S-GlcA­(1→3)­GlcNAc and β-S-Gal­(1→3)­GlcNAc thiodisaccharides, which can be considered mimetics of the repeating units of hyaluronan and…”
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Second-Generation Dendrimers with Chondroitin Sulfate Type‑E Disaccharides as Multivalent Ligands for Langerin by Domínguez-Rodríguez, Pedro, Vivès, Corinne, Thepaut, Michel, Fieschi, Franck, Nieto, Pedro M, de Paz, José L, Rojo, Javier

“…Chondroitin sulfate type-E (CS-E) is a sulfated polysaccharide that shows several interesting biological activities, such as modulation of the neuronal growth…”
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Synthesis, structure and midkine binding of chondroitin sulfate oligosaccharide analogues by Torres-Rico, Myriam, Maza, Susana, de Paz, José L, Nieto, Pedro M

“…The preparation of chondroitin sulfate (CS) oligosaccharide mimetics, more easily synthesized than natural sequences, is a highly interesting task because…”
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High‐Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC‐SIGN and Langerin by Herrera‐González, Irene, González‐Cuesta, Manuel, Thépaut, Michel, Laigre, Eugénie, Goyard, David, Rojo, Javier, García Fernández, José M., Fieschi, Franck, Renaudet, Olivier, Nieto, Pedro M., Ortiz Mellet, Carmen

“…The “carbohydrate chemical mimicry” exhibited by sp2‐iminosugars has been utilized to develop practical syntheses for analogs of the branched high‐mannose‐type…”
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Fluorous-tag assisted synthesis of a glycosaminoglycan mimetic tetrasaccharide as a high-affinity FGF-2 and midkine ligand by Maza, Susana, Gandia-Aguado, Noel, de Paz, José L., Nieto, Pedro M.

“…[Display omitted] Here, we present the preparation of a sulfated, fully protected tetrasaccharide derivative following the glycosaminoglycan (GAG)-related…”
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Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments by Muñoz-García, Juan C, Chabrol, Eric, Vivès, Romain R, Thomas, Aline, de Paz, José L, Rojo, Javier, Imberty, Anne, Fieschi, Franck, Nieto, Pedro M, Angulo, Jesús

“…Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent…”
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The Use of NMR to Study Transient Carbohydrate-Protein Interactions by Nieto, Pedro M

“…Carbohydrates are biologically ubiquitous and are essential to the existence of all known living organisms. Although they are better known for their role as…”
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The Interaction between Chondroitin Sulfate and Dermatan Sulfate Tetrasaccharides and Pleiotrophin by García-Jiménez, María Jose, Torres-Rico, Myriam, de Paz, José L, Nieto, Pedro M

“…Pleiotrophin (PTN) is a neurotrophic factor that participates in the development of the embryonic central nervous system (CNS) and neural stem cell regulation…”
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Glycodendrimers as Chondroitin Sulfate Mimetics: Synthesis and Binding to Growth Factor Midkine by Domínguez‐Rodríguez, Pedro, Reina, José J., Gil‐Caballero, Sergio, Nieto, Pedro M., de Paz, José L., Rojo, Javier

“…Chondroitin sulfate (CS) is a member of the glycosaminoglycan (GAG) family, a class of polysaccharides implicated in relevant biological functions. The…”
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Structure of a Glycomimetic Ligand in the Carbohydrate Recognition Domain of C‑type Lectin DC-SIGN. Structural Requirements for Selectivity and Ligand Design by Thépaut, Michel, Guzzi, Cinzia, Sutkeviciute, Ieva, Sattin, Sara, Ribeiro-Viana, Renato, Varga, Norbert, Chabrol, Eric, Rojo, Javier, Bernardi, Anna, Angulo, Jesus, Nieto, Pedro M, Fieschi, Franck

“…In genital mucosa, different fates are described for HIV according to the subtype of dendritic cells (DCs) involved in its recognition. This notably depends on…”
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Glycosaminoglycans: What Remains To Be Deciphered? by Perez, Serge, Makshakova, Olga, Angulo, Jesus, Bedini, Emiliano, Bisio, Antonella, de Paz, Jose Luis, Fadda, Elisa, Guerrini, Marco, Hricovini, Michal, Hricovini, Milos, Lisacek, Frederique, Nieto, Pedro M., Pagel, Kevin, Paiardi, Giulia, Richter, Ralf, Samsonov, Sergey A., Vivès, Romain R., Nikitovic, Dragana, Ricard Blum, Sylvie

“…Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural diversity and fulfilling various functions mediated by thousands of…”
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Synthesis of a Fluorous-Tagged Hexasaccharide and Interaction with Growth Factors Using Sugar-Coated Microplates by Maza, Susana, de Paz, José L, Nieto, Pedro M

“…Here, we report the synthesis of a sulfated, fully protected hexasaccharide as a glycosaminoglycan mimetic and the study of its interactions with different…”
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Synthesis and interaction with growth factors of sulfated oligosaccharides containing an anomeric fluorinated tail by de Paz, José L., García-Jiménez, María José, Jafari, Vahid, García-Domínguez, Mario, Nieto, Pedro M.

“…[Display omitted] •Sulfated oligosaccharides were synthesized as glycosaminoglycan (GAG) mimetics.•The synthesis was facilitated by the presence of a…”
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Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine by Solera, Cristina, Macchione, Giuseppe, Maza, Susana, Kayser, M. Mar, Corzana, Francisco, de Paz, José L., Nieto, Pedro M.

“…The biological activity of midkine, a cytokine implicated in neuro‐ and tumourigenesis, is regulated by its binding to glycosaminoglycans (GAGs), such as…”
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Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics by Miles, Jonathan R, Wang, Xu, de Paz, Jose L, Nieto, Pedro M

“…Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution…”
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