Search Results - "Nieto, Lur Agirrezabala"
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Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
Published in Molecular psychiatry (01-08-2022)“…Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer’s disease (AD) risk and AD biomarker levels…”
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Effects of a liver APOEε4‐genotype on synaptic integrity, gliosis and insulin signaling in the brain
Published in Alzheimer's & dementia (01-12-2020)“…Background APOEε4 is the strongest genetic risk factor for AD[1]. Although plasma apoE does not cross the blood‐brain‐barrier[2], altered plasma apoE levels…”
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