Search Results - "Niethammer, A. G."

DNA vaccines designed to inhibit tumor growth by suppression of angiogenesis by Reisfeld, Ralph A, Niethammer, A G, Luo, Y, Xiang, R

“…The development of new blood vessels, i.e. angiogenesis, is a rate-limiting step in the development of tumors since tumor growth is generally limited to 1-2…”
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MIG (CXCL9) chemokine gene therapy combines with antibody-cytokine fusion protein to suppress growth and dissemination of murine colon carcinoma by RUEHLMANN, J. Michael, RONG XIANG, NIETHAMMER, Andreas G, YI BA, PERTL, Ursula, DOLMAN, Carrie S, GILLIES, Stephen D, REISFELD, Ralph A

“…The induction of a CTL response capable of eradicating disseminated tumor metastases and the establishment of a persistent tumor-protective immunity remain…”
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Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma by NIETHAMMER, Andreas G, RONG XIANG, RUEHLMANN, J. Michael, LODE, Holger N, DOLMAN, Carrie S, GILLIES, Stephen D, REISFELD, Ralph A

“…We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective…”
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A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth by Niethammer, A G, Xiang, R, Becker, J C, Wodrich, H, Pertl, U, Karsten, G, Eliceiri, B P, Reisfeld, R A

“…Tumor cells are elusive targets for immunotherapy due to their heterogeneity and genetic instability. Here we describe a novel, oral DNA vaccine that targets…”
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Potential target antigens for immunotherapy in human pancreatic cancer by Schmitz-Winnenthal, F.H, Galindo-Escobedo, L.V, Rimoldi, D, Geng, W, Romero, P, Koch, M, Weitz, J, Krempien, R, Niethammer, A.G, Beckhove, P, Buchler, M.W, Z’graggen, K

“…Abstract Background To be effective and selective, immunotherapy ideally targets specifically tumor cells and spares normal tissues. Identification of tumor…”
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Use of the platelet histogram maximum in evaluating thrombocytopenia by Niethammer, Andreas G., Forman, Edwin N.

“…The purpose of this study was to compare the mean platelet volume (MPV) and the highest peak of the platelet volume distribution curve (maximum of the platelet…”
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A Dual-Function DNA Vaccine Encoding Carcinoembryonic Antigen and CD40 Ligand Trimer Induces T Cell-Mediated Protective Immunity Against Colon Cancer in Carcinoembryonic Antigen-Transgenic Mice by Xiang, Rong, Primus, F. James, Ruehlmann, J. Michael, Niethammer, Andreas G, Silletti, Steve, Lode, Holger N, Dolman, Carrie S, Gillies, Stephen D, Reisfeld, Ralph A

“…A carcinoembryonic Ag (CEA)-based DNA vaccine encoding both CEA and CD40 ligand trimer achieved effective tumor-protective immunity against murine colon…”
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Multidrug resistance-1 (MDR-1): a new target for T cell-based immunotherapy by Niethammer, Andreas G, Wodrich, Harald, Loeffler, Markus, Lode, Holger N, Emmerich, Kathrin, Abdollahi, Amir, Krempien, Robert, Debus, Juergen, Huber, Peter E, Reisfeld, Ralph A

“…ABSTRACT Acquired multidrug resistance (MDR) remains a major challenge in the treatment of cancer with chemotherapeutic drugs. It can be mediated by the…”
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An oral DNA vaccine against human carcinoembryonic antigen (CEA) prevents growth and dissemination of Lewis lung carcinoma in CEA transgenic mice by Niethammer, Andreas G, Primus, F.James, Xiang, Rong, Dolman, Carrie S, Ruehlmann, J.Michael, Ba, Yi, Gillies, Stephen D, Reisfeld, Ralph A

“…A DNA vaccine encoding human carcinoembryonic antigen (CEA) broke peripheral T-cell tolerance toward this tumor self-antigen expressed by Lewis lung carcinoma…”
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Protective Immunity against Human Carcinoembryonic Antigen (CEA) Induced by an Oral DNA Vaccine in CEA-transgenic Mice by RONG XIANG, SILLETTI, Steve, LODE, Holger N, DOLMAN, Carrie S, RUEHLMANN, J. Michael, NIETHAMMER, Andreas G, PERTL, Ursula, GILLIES, Stephen D, PRIMUS, F. James, REISFELD, Ralph A

“…Peripheral T-cell tolerance toward human carcinoembryonic self-antigen (CEA) was broken in CEA-transgenic C57BL/6J mice by an oral CEA-based DNA vaccine. This…”
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Vaccination Against VEGFR2 Attenuates Initiation and Progression of Atherosclerosis by Hauer, Arnaud D, van Puijvelde, Gijs H.M, Peterse, Niels, de Vos, Paula, van Weel, Vincent, van Wanrooij, Eva J.A, Biessen, Erik A.L, Quax, Paul H.A, Niethammer, Andreas G, Reisfeld, Ralph A, van Berkel, Theo J.C, Kuiper, Johan

“…OBJECTIVE—Vascular endothelial growth factor receptor 2 (VEGFR2)–overexpressing cells may form an interesting target for the treatment of atherosclerosis…”
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SELECTIVE EXPRESSION OF TUMOR ASSOCIATED ANTIGENS BY SAMPLES DERIVED FROM HUMAN PANCREATIC CANCER by Schmitz-Winnenthal, F. H., Galindo-Escobedo, L. V., Rimoldi, D., Geng, W., Romero, P., Koch, M., Weitz, J., Krempien, R., Niethammer, A. G., Beckhove, P., Buchler, M. W., Z'graggen, K.

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Intraoperative electron boost radiation followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma by Oertel, Susanne, Treiber, Martina, Zahlten-Hinguranage, Angelika, Eichin, Steffen, Roeder, Falk, Funk, Angela, Hensley, Frank W, Timke, Carmen, Niethammer, Andreas G, Huber, Peter E, Weitz, Juergen, Eble, Micheal J, Buchler, Markus W, Bernd, Ludger, Debus, Jürgen, Krempien, Robert C

“…To analyze long-term prognosis and morbidity after limb-sparing treatment of patients with extremity soft-tissue sarcoma, with intraoperative electron boost…”
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DNA vaccines suppress tumor growth and metastases by the induction of anti-angiogenesis by Reisfeld, Ralph A., Niethammer, Andreas G., Luo, Yunping, Xiang, Rong

“…Four novel oral DNA vaccines provide long‐lived protection against melanoma, colon, breast, and non‐small cell lung carcinoma in mouse model systems. The…”
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Combination of external-beam radiotherapy with intraoperative electron-beam therapy is effective in incompletely resected pediatric malignancies by Oertel, Susanne, Niethammer, Andreas G, Krempien, Robert, Roeder, Falk, Eble, Michael J, Baer, Claudia, Huber, Peter E, Kulozik, Andreas, Waag, Karl-Ludwig, Treiber, Martina, Debus, Juergen

“…Intraoperative electron-beam radiotherapy (IOERT) has been applied for local dose escalation in over 1,400 patients in Heidelberg since 1991. Among these were…”
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Bisphosphonates and bone metastases: current status and future directions by Krempien, Robert, Niethammer, Andreas, Harms, Wolfgang, Debus, Jürgen

“…Since bone metastases in advanced cancer are common and frequently lead to skeletal-related morbid complications, their treatment remains a major challenge in…”
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