Search Results - "Niessing, Dierk"

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation by Hofweber, Mario, Hutten, Saskia, Bourgeois, Benjamin, Spreitzer, Emil, Niedner-Boblenz, Annika, Schifferer, Martina, Ruepp, Marc-David, Simons, Mikael, Niessing, Dierk, Madl, Tobias, Dormann, Dorothee

“…Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key…”
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Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3 by Schneider, Tim, Hung, Lee-Hsueh, Aziz, Masood, Wilmen, Anna, Thaum, Stephanie, Wagner, Jacqueline, Janowski, Robert, Müller, Simon, Schreiner, Silke, Friedhoff, Peter, Hüttelmaier, Stefan, Niessing, Dierk, Sattler, Michael, Schlundt, Andreas, Bindereif, Albrecht

“…How multidomain RNA-binding proteins recognize their specific target sequences, based on a combinatorial code, represents a fundamental unsolved question and…”
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Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging by Mishra, Kanuj, Fuenzalida-Werner, Juan Pablo, Pennacchietti, Francesca, Janowski, Robert, Chmyrov, Andriy, Huang, Yuanhui, Zakian, Christian, Klemm, Uwe, Testa, Ilaria, Niessing, Dierk, Ntziachristos, Vasilis, Stiel, Andre C.

“…Reversibly photo-switchable proteins are essential for many super-resolution fluorescence microscopic and optoacoustic imaging methods. However, they have yet…”
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The Molecular Function of PURA and Its Implications in Neurological Diseases by Molitor, Lena, Bacher, Sabrina, Burczyk, Sandra, Niessing, Dierk

“…In recent years, genome-wide analyses of patients have resulted in the identification of a number of neurodevelopmental disorders. Several of them are caused…”
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Structural features of Argonaute–GW182 protein interactions by Pfaff, Janina, Hennig, Janosch, Herzog, Franz, Aebersold, Ruedi, Sattler, Michael, Niessing, Dierk, Meister, Gunter

“…MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to target mRNAs, leading to gene silencing. However, Ago proteins are not the actual mediators of gene…”
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Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains by Heber, Simone, Gáspár, Imre, Tants, Jan-Niklas, Günther, Johannes, Moya, Sandra M. Fernandez, Janowski, Robert, Ephrussi, Anne, Sattler, Michael, Niessing, Dierk

“…Throughout metazoans, Staufen (Stau) proteins are core factors of mRNA localization particles. They consist of three to four double-stranded RNA binding…”
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Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses by Behrens, Gesine, Edelmann, Stephanie L., Raj, Timsse, Kronbeck, Nina, Monecke, Thomas, Davydova, Elena, Wong, Elaine H., Kifinger, Lisa, Giesert, Florian, Kirmaier, Martin E., Hohn, Christine, de Jonge, Laura S., Pisfil, Mariano Gonzalez, Fu, Mingui, Theurich, Sebastian, Feske, Stefan, Kawakami, Naoto, Wurst, Wolfgang, Niessing, Dierk, Heissmeyer, Vigo

“…Roquin and Regnase-1 proteins bind and post-transcriptionally regulate proinflammatory target messenger RNAs to maintain immune homeostasis. Either the…”
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Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation by Schlundt, Andreas, Heinz, Gitta A, Janowski, Robert, Geerlof, Arie, Stehle, Ralf, Heissmeyer, Vigo, Niessing, Dierk, Sattler, Michael

“…Roquin controls T-cell activity through interactions with mRNAs of stimulatory receptors. Structural and functional elucidation of its RNA-binding domain…”
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Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c by Velvarska, Hana, Niessing, Dierk

“…Vertebrate type V myosins (MyoV) Myo5a, Myo5b, and Myo5c mediate transport of several different cargoes. All MyoV paralogs bind to cargo complexes mainly by…”
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Presence and function of Hbl B', the fourth protein component encoded by the hbl operon in Bacillus cereus by Jessberger, Nadja, Dietrich, Richard, Janowski, Robert, Niessing, Dierk, Märtlbauer, Erwin

“…The genes hblC, hblD and hblA encode the components Hbl L2, L1 and B of the pore forming enterotoxin haemolysin BL of Bacillus cereus. Two variants of the…”
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X-ray structure of Pur-α reveals a Whirly-like fold and an unusual nucleic-acid binding surface by Graebsch, Almut, Roche, Stéphane, Niessing, Dierk

“…The PUR protein family is a distinct and highly conserved class that is characterized by its sequence-specific RNA- and DNA-binding. Its best-studied family…”
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mRNA transport in fungal top models by Niessing, Dierk, Jansen, Ralf‐Peter, Pohlmann, Thomas, Feldbrügge, Michael

“…Eukaryotic cells rely on the precise determination of when and where proteins are synthesized. Spatiotemporal expression is supported by localization of mRNAs…”
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PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association by Proske, Marcel, Janowski, Robert, Bacher, Sabrina, Kang, Hyun-Seo, Monecke, Thomas, Koehler, Tony, Hutten, Saskia, Tretter, Jana, Crois, Anna, Molitor, Lena, Varela-Rial, Alejandro, Fino, Roberto, Donati, Elisa, De Fabritiis, Gianni, Dormann, Dorothee, Sattler, Michael, Niessing, Dierk

“…Mutations in the human gene cause the neurodevelopmental PURA syndrome. In contrast to several other monogenetic disorders, almost all reported mutations in…”
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Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40 by Janowski, Robert, Heinz, Gitta A., Schlundt, Andreas, Wommelsdorf, Nina, Brenner, Sven, Gruber, Andreas R., Blank, Michael, Buch, Thorsten, Buhmann, Raymund, Zavolan, Mihaela, Niessing, Dierk, Heissmeyer, Vigo, Sattler, Michael

“…The RNA-binding protein Roquin is required to prevent autoimmunity. Roquin controls T-helper cell activation and differentiation by limiting the induced…”
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RNA recognition by Roquin in posttranscriptional gene regulation by Schlundt, Andreas, Niessing, Dierk, Heissmeyer, Vigo, Sattler, Michael

“…Posttranscriptional regulation of gene expression plays a central role in the initiation of innate and adaptive immune responses. This is exemplified by the…”
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Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation by Walcher, Tessa, Xie, Qing, Sun, Jian, Irmler, Martin, Beckers, Johannes, Öztürk, Timucin, Niessing, Dierk, Stoykova, Anastassia, Cvekl, Ales, Ninkovic, Jovica, Götz, Magdalena

“…To achieve adequate organ development and size, cell proliferation and differentiation have to be tightly regulated and coordinated. The transcription factor…”
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Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator by Schlundt, Andreas, Buchner, Sophie, Janowski, Robert, Heydenreich, Thomas, Heermann, Ralf, Lassak, Jürgen, Geerlof, Arie, Stehle, Ralf, Niessing, Dierk, Jung, Kirsten, Sattler, Michael

“…The transmembrane DNA-binding protein CadC of E. coli , a representative of the ToxR-like receptor family, combines input and effector domains for signal…”
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Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS by Zinngrebe, Julia, Moepps, Barbara, Monecke, Thomas, Gierschik, Peter, Schlichtig, Ferdinand, Barth, Thomas F E, Strauß, Gudrun, Boldrin, Elena, Posovszky, Carsten, Schulz, Ansgar, Beringer, Ortraud, Rieser, Eva, Jacobsen, Eva‐Maria, Lorenz, Myriam Ricarda, Schwarz, Klaus, Pannicke, Ulrich, Walczak, Henning, Niessing, Dierk, Schuetz, Catharina, Fischer‐Posovszky, Pamela, Debatin, Klaus‐Michael

“…Autoinflammatory diseases are a heterogenous group of disorders defined by fever and systemic inflammation suggesting involvement of genes regulating innate…”
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Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4 by Janowski, Robert, Scanu, Sandra, Niessing, Dierk, Madl, Tobias

“…The mammalian glutathione peroxidase (GPx) family is a key component of the cellular antioxidative defence system. Within this family, GPx4 has unique features…”
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Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA by Rehage, Nina, Davydova, Elena, Conrad, Christine, Behrens, Gesine, Maiser, Andreas, Stehklein, Jenny E., Brenner, Sven, Klein, Juliane, Jeridi, Aicha, Hoffmann, Anne, Lee, Eunhae, Dianzani, Umberto, Willemsen, Rob, Feederle, Regina, Reiche, Kristin, Hackermüller, Jörg, Leonhardt, Heinrich, Sharma, Sonia, Niessing, Dierk, Heissmeyer, Vigo

“…The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin…”
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