Search Results - "Niessen, W.M.A."

Matrix effects in quantitative pesticide analysis using liquid chromatography-mass spectrometry by Niessen, W.M.A., Manini, P., Andreoli, R.

“…Combined liquid chromatography–mass spectrometry using electrospray or atmospheric‐pressure chemical ionization has become an important tool in the…”
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Fragmentation of toxicologically relevant drugs in positive-ion liquid chromatography-tandem mass spectrometry by Niessen, W.M.A.

“…The identification of drugs and related compounds by LC–MS–MS is an important analytical challenge in several application areas, including clinical and…”
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Fragmentation of toxicologically relevant drugs in negative-ion liquid chromatography-tandem mass spectrometry by Niessen, W.M.A.

“…Negative‐ion LC–MS analysis of drugs is applied far less frequently than positive‐ion LC–MS. Data on the interpretation of negative‐ion MS–MS spectra are even…”
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Analysis of biologically-active, endogenous carboxylic acids based on chromatography-mass spectrometry by Kloos, D., Lingeman, H., Mayboroda, O.A., Deelder, A.M., Niessen, W.M.A., Giera, M.

“…•Analysis of fatty acids, eicosanoids, small carboxylic acids and bile acids.•We explain the pitfalls and the advantages of LC-MS and GC-MS platforms.•Overview…”
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Group-specific fragmentation of pesticides and related compounds in liquid chromatography–tandem mass spectrometry by Niessen, W.M.A.

“…Current strategies in the LC–MS analysis of pesticides and related compounds in environmental samples, fruits and vegetables, and biological samples mostly…”
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Progress in liquid chromatography–mass spectrometry instrumentation and its impact on high-throughput screening by Niessen, W.M.A.

“…In the past 10 years, liquid chromatography–mass spectrometry (LC–MS) has rapidly matured to become a very powerful and useful analytical tool that is widely…”
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Protein digestion optimization for characterization of drug–protein adducts using response surface modeling by Switzar, L., Giera, M., Lingeman, H., Irth, H., Niessen, W.M.A.

“…The formation of drug–protein adducts in vivo may have important clinical and toxicological implications. Consequently, there is a great interest in the…”
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State-of-the-art in liquid chromatography–mass spectrometry by Niessen, W.M.A

“…Impressive progress has been made in the technology and application of combined liquid chromatography–mass spectrometry (LC–MS) in the past decennium. From a…”
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Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction-liquid chromatography–mass spectrometry with positive-ion electrospray ionization by Kloos, D., Derks, R.J.E., Wijtmans, M., Lingeman, H., Mayboroda, O.A., Deelder, A.M., Niessen, W.M.A., Giera, M.

“…The analysis of cellular metabolic processes is of fundamental biological interest. Cellular metabolites, such as the intermediates of the tricarboxylic acid…”
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P.1.g.013 Identification of novel bioactives on the alpha-7-nAChR using an at-line cellular bioassay after nanofractionation by Otvos, R.A, Mladic, M, Alpizar, G. Arias, Niessen, W.M.A, Somsen, G.W, Smit, A.B, Kool, J

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Advances in instrumentation in liquid chromatography–mass spectrometry and related liquid-introduction techniques by Niessen, W.M.A

“…In the past few years, the instrumental developments in the field of combined liquid chromatography–mass spectrometry (LC–MS) and related liquid-introduction…”
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Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI–MS(/MS) applied for the analysis of prostanoids and NSAID in urine by Kretschmer, A., Giera, M., Wijtmans, M., de Vries, L., Lingeman, H., Irth, H., Niessen, W.M.A.

“…In order to develop a generic positive ionization ESI LC–MS method for a variety of interesting substance classes, a new derivatization strategy for carboxylic…”
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Analysis of antibiotics by liquid chromatography–mass spectrometry by Niessen, W.M.A

“…The current status of the application of LC–MS in the analysis of antibiotic and antibacterial compounds is reviewed. The main application area of LC–MS in…”
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Identification and quantification of drug–albumin adducts in serum samples from a drug exposure study in mice by Switzar, L., Kwast, L.M., Lingeman, H., Giera, M., Pieters, R.H.H., Niessen, W.M.A.

“…► A generic strategy was developed for the analysis of drug–albumin adducts in serum. ► Identification and localization of low-abundant NAPQI-albumin adducts…”
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High-resolution metabolic profiling towards G protein-coupled receptors: Rapid and comprehensive screening of histamine H4 receptor ligands by Kool, J., Rudebeck, A.F., Fleurbaaij, F., Nijmeijer, S., Falck, D., Smits, R.A., Vischer, H.F., Leurs, R., Niessen, W.M.A.

“…► High-resolution metabolic profiling of drugs and lead compounds for the histamine H4 receptor. ► Mass spectrometry was used to correlate metabolite…”
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Tandem mass spectrometry of organic nitro and halogen compounds: Competition between losses of molecules and of radicals by Niessen, W.M.A.

“…Fragmentation of protonated and/or deprotonated small-molecule compounds in tandem mass spectrometry after electrospray ionization involves complex processes…”
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Tandem mass spectrometry of small-molecule antiviral drugs: 2. hepatitis-related antivirals by Niessen, W.M.A.

“…Antiviral drugs are a class of compounds developed specifically for the treatment of viral infections. Quantitative analysis of antiviral drugs in biological…”
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Interpretation of tandem mass spectra of antiepileptic drugs using accurate-m/z data and m/z-shifts with stable-isotope labeled analogues by Niessen, W.M.A.

“…Anticonvulsant or antiepileptic drugs (AEDs) show a great structural diversity. Often, therapeutic drug monitoring (TDM) based on liquid…”
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Tandem mass spectrometry of small-molecule antiviral drugs: 3. antiviral agents against herpes, influenza and other viral infections by Niessen, W.M.A.

“…For the treatment of various viral infections, antiviral drugs may be used. Liquid chromatography–mass spectrometry (LC–MS) with tandem mass spectrometry…”
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Tandem mass spectrometry of small-molecule antiviral drugs: 1. HIV-related antivirals by Niessen, W.M.A.

“…Antiviral drugs are a class of compounds developed specifically for the treatment of viral infections. In the development and subsequent application of…”
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