Search Results - "Niessen, M."

Tight Junctions/Adherens Junctions: Basic Structure and Function by Niessen, Carien M.

“…Adherens and tight junctions are intercellular junctions crucial for epithelial adhesion and barrier function in a wide variety of tissues and organisms. In…”
Get full text

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage by Nava, Michele M., Miroshnikova, Yekaterina A., Biggs, Leah C., Whitefield, Daniel B., Metge, Franziska, Boucas, Jorge, Vihinen, Helena, Jokitalo, Eija, Li, Xinping, García Arcos, Juan Manuel, Hoffmann, Bernd, Merkel, Rudolf, Niessen, Carien M., Dahl, Kris Noel, Wickström, Sara A.

“…Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei,…”
Get full text

Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization by Wickström, Sara A, Niessen, Carien M

“…Biological patterns emerge through specialization of genetically identical cells to take up distinct fates according to their position within the organism. How…”
Get full text

Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation by Niessen, Carien M, Leckband, Deborah, Yap, Alpha S

“…This review addresses the cellular and molecular mechanisms of cadherin-based tissue morphogenesis. Tissue physiology is profoundly influenced by the…”
Get full text

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment by Le, Huy Quang, Ghatak, Sushmita, Yeung, Ching-Yan Chloé, Tellkamp, Frederik, Günschmann, Christian, Dieterich, Christoph, Yeroslaviz, Assa, Habermann, Bianca, Pombo, Ana, Niessen, Carien M., Wickström, Sara A.

“…Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to control stem cell fate and self-organization remains unclear. We show that a…”
Get full text

Calling long distance: Cell cycle-dependent Ca2+ flows connect stem cells across regeneration tissues by Goranci-Buzhala, Gladiola, Niessen, Carien M

“…How adult stem cells signal in vivo over time to coordinate their fate and behavior across self-renewing tissues remains a challenging question. In this issue,…”
Get full text

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species by Baglio, Serena Rubina, Rooijers, Koos, Koppers-Lalic, Danijela, Verweij, Frederik J, Pérez Lanzón, M, Zini, Nicoletta, Naaijkens, Benno, Perut, Francesca, Niessen, Hans W M, Baldini, Nicola, Pegtel, D Michiel

“…Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders…”
Get full text

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective by Rübsam, Matthias, Broussard, Joshua A, Wickström, Sara A, Nekrasova, Oxana, Green, Kathleen J, Niessen, Carien M

“…Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple intercellular adhesion to the actin or intermediate filament cytoskeletons,…”
Get full text

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch by Kong, Xiangjun, Kuilman, Thomas, Shahrabi, Aida, Boshuizen, Julia, Kemper, Kristel, Song, Ji-Ying, Niessen, Hans W. M., Rozeman, Elisa A., Geukes Foppen, Marnix H., Blank, Christian U., Peeper, Daniel S.

“…The identification of an ERK2–JUNB–FRA1 signalling pathway that drives addiction to therapeutic drugs in cancer cells, and an ERK2-dependent phenotype switch…”
Get full text

Simulation of melt film dynamics in laser fusion cutting using a boundary layer approximation by Halm, U., Nießen, M., Schulz, W.

“…•3D Simulation of melt film dynamics in laser fusion cutting.•Calculation of cut surface profiles including striation amplitude and wavelength.•Evaluate effect…”
Get full text

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning by Rübsam, Matthias, Mertz, Aaron F., Kubo, Akiharu, Marg, Susanna, Jüngst, Christian, Goranci-Buzhala, Gladiola, Schauss, Astrid C., Horsley, Valerie, Dufresne, Eric R., Moser, Markus, Ziegler, Wolfgang, Amagai, Masayuki, Wickström, Sara A., Niessen, Carien M.

“…Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal…”
Get full text

Tracing the Evolutionary Origin of Desmosomes by Green, Kathleen J., Roth-Carter, Quinn, Niessen, Carien M., Nichols, Scott A.

“…Cadherin-based cell–cell junctions help metazoans form polarized sheets of cells, which are necessary for the development of organs and the…”
Get full text

Recent Advancements in the LC- and GC-Based Analysis of Malondialdehyde (MDA): A Brief Overview by Giera, Martin, Lingeman, Henk, Niessen, Wilfried M. A.

“…Malondialdehyde (MDA) is an end-product of lipid peroxidation and a side product of thromboxane A 2 synthesis. Moreover, it is not only a frequently measured…”
Get full text

Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate by Vorhagen, Susanne, Niessen, Carien M.

“…Oriented cell division is a key regulator of tissue architecture and crucial for morphogenesis and homeostasis. Balanced regulation of proliferation and…”
Get full text

Methodological Issues in Soccer Talent Identification Research by Bergkamp, Tom L. G., Niessen, A. Susan M., den Hartigh, Ruud. J. R., Frencken, Wouter G. P., Meijer, Rob R.

“…Talent identification research in soccer comprises the prediction of elite soccer performance. While many studies in this field have aimed to empirically…”
Get full text

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes by Brouwers, Olaf, Niessen, Petra M. G., Miyata, Toshio, Østergaard, Jakob A., Flyvbjerg, Allan, Peutz-Kootstra, Carine J., Sieber, Jonas, Mundel, Peter H., Brownlee, Michael, Janssen, Ben J. A., De Mey, Jo G. R., Stehouwer, Coen D. A., Schalkwijk, Casper G.

“…Aims/hypothesis In diabetes, advanced glycation end-products (AGEs) and the AGE precursor methylglyoxal (MGO) are associated with endothelial dysfunction and…”
Get full text

Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir by van der Laan, Anja M, Ter Horst, Ellis N, Delewi, Ronak, Begieneman, Mark P V, Krijnen, Paul A J, Hirsch, Alexander, Lavaei, Mehrdad, Nahrendorf, Matthias, Horrevoets, Anton J, Niessen, Hans W M, Piek, Jan J

“…Monocytes are critical mediators of healing following acute myocardial infarction (AMI), making them an interesting target to improve myocardial repair. The…”
Get full text

Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment by Niessen, Natalie M., Gibson, Peter G., Baines, Katherine J., Barker, Daniel, Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Simpson, Jodie L., Fricker, Michael

“…Background The AMAZES randomized controlled trial demonstrated that long‐term low‐dose azithromycin treatment reduces exacerbations of poorly controlled…”
Get full text

Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces by Mertz, Aaron F., Che, Yonglu, Banerjee, Shiladitya, Goldstein, Jill M., Rosowski, Kathryn A., Revilla, Stephen F., Niessen, Carien M., Marchetti, M. Cristina, Dufresne, Eric R., Horsley, Valerie

“…Cell–cell and cell–matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between these…”
Get full text

Admission testing for higher education: A multi-cohort study on the validity of high-fidelity curriculum-sampling tests by Niessen, A Susan M, Meijer, Rob R, Tendeiro, Jorge N

“…We investigated the validity of curriculum-sampling tests for admission to higher education in two studies. Curriculum-sampling tests mimic representative…”
Get full text