Search Results - "Nieslanik, Brenda S."

The Catalytic Tyr-9 of Glutathione S-Transferase A1-1 Controls the Dynamics of the C terminus by Nieslanik, Brenda S., Atkins, William M.

“…The glutathione S-transferase enzymes (GSTs) have a tyrosine or serine residue at their active site that hydrogen bonds to and stabilizes the thiolate anion of…”
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The C-Terminus of Glutathione S-Transferase A1-1 Is Required for Entropically-Driven Ligand Binding by Nieslanik, Brenda S, Ibarra, Catherine, Atkins, William M

“…Binding of a hydrophobic glutathione product conjugate to rGST A1-1 proceeds via a two-step mechanism, including rapid ligand docking, followed by a slow…”
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Stopped-Flow Kinetic Analysis of the Ligand-Induced Coil−Helix Transition in Glutathione S-Transferase A1-1:  Evidence for a Persistent Denatured State by Nieslanik, Brenda S, Dabrowski, Michael J, Lyon, Robert P, Atkins, William M

“…Structural studies have suggested that the glutathione S-transferase (GST) A1-1 isozyme contains a dynamic C-terminus which undergoes a ligand-dependent…”
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Contribution of Linear Free Energy Relationships to Isozyme- and pH-Dependent Substrate Selectivity of Glutathione S-Transferases:  Comparison of Model Studies and Enzymatic Reactions by Nieslanik, Brenda S, Atkins, William M

“…A novel application of linear free energy relationships is described in which the substrate selectivities and pH dependencies of glutathione S-transferases…”
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Thiol Ester Hydrolysis Catalyzed by Glutathione S-Transferase A1-1 by Dietze, Eric C, Grillo, Mark P, Kalhorn, Thomas, Nieslanik, Brenda S, Jochheim, Claudia M, Atkins, William M

“…rGSTA1-1 has been shown to catalyze the hydrolysis of the thiol ester glutathionyl ethacrynate (E-SG). In contrast, neither the retro-Michael addition with the…”
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Contribution of Aromatic−Aromatic Interactions to the Anomalous pKa of Tyrosine-9 and the C-Terminal Dynamics of Glutathione S-Transferase A1-1 by IBARRA, Catherine, NIESLANIK, Brenda S., ATKINS, William M.

“…Most cytosolic glutathione S -transferases (GSTs) exploit a hydrogen bond between an active site Tyr and the bound glutathione (GSH) cofactor to lower the p K…”
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Contribution of Aromatic−Aromatic Interactions to the Anomalous pK a of Tyrosine-9 and the C-Terminal Dynamics of Glutathione S-Transferase A1-1 by Ibarra, Catherine, Nieslanik, Brenda S, Atkins, William M

“…Most cytosolic glutathione S-transferases (GSTs) exploit a hydrogen bond between an active site Tyr and the bound glutathione (GSH) cofactor to lower the pK a…”
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Contribution of Aromatic−Aromatic Interactions to the Anomalous p K a of Tyrosine-9 and the C-Terminal Dynamics of Glutathione S -Transferase A1-1 by Ibarra, Catherine, Nieslanik, Brenda S., Atkins, William M.

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Localization of the C-terminus of rat glutathione S-transferase A1-1: Crystal structure of mutants W21F and W21F/F220Y by Adman, Elinor T., Le Trong, Isolde, Stenkamp, Ronald E., Nieslanik, Brenda S., Dietze, Eric C., Tai, Guoying, Ibarra, Catherine, Atkins, William M.

“…Twelve C‐terminal residues of human glutathione S‐transferase A1‐1 form a helix in the presence of glutathione‐conjugate, or substrate alone, and partly cover…”
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