Search Results - "Niesen, Michiel J.M."

A Link between Integral Membrane Protein Expression and Simulated Integration Efficiency by Marshall, Stephen S., Niesen, Michiel J.M., Müller, Axel, Tiemann, Katrin, Saladi, Shyam M., Galimidi, Rachel P., Zhang, Bin, Clemons, William M., Miller, Thomas F.

“…Integral membrane proteins (IMPs) control the flow of information and nutrients across cell membranes, yet IMP mechanistic studies are hindered by difficulties…”
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FDA-authorized mRNA COVID-19 vaccines are effective per real-world evidence synthesized across a multi-state health system by Pawlowski, Colin, Lenehan, Patrick, Puranik, Arjun, Agarwal, Vineet, Venkatakrishnan, A J, Niesen, Michiel J M, O'Horo, John C, Virk, Abinash, Swift, Melanie D, Badley, Andrew D, Halamka, John, Soundararajan, Venky

“…Two US Food and Drug Administration (FDA)-authorized coronavirus disease 2019 (COVID-19) mRNA vaccines, BNT162b2 (Pfizer/BioNTech) and mRNA-1273 (Moderna),…”
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Force transduction creates long-ranged coupling in ribosomes stalled by arrest peptides by Zimmer, Matthew H., Niesen, Michiel J.M., Miller, Thomas F.

“…Force-sensitive arrest peptides regulate protein biosynthesis by stalling the ribosome as they are translated. Synthesis can be resumed when the nascent arrest…”
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Comparative effectiveness of mRNA-1273 and BNT162b2 against symptomatic SARS-CoV-2 infection by Puranik, Arjun, Lenehan, Patrick J, Silvert, Eli, Niesen, Michiel J M, Corchado-Garcia, Juan, O'Horo, John C, Virk, Abinash, Swift, Melanie D, Gordon, Joel E, Speicher, Leigh Lewis, Geyer, Holly L, Kremers, Walter, Halamka, John, Badley, Andrew D, Venkatakrishnan, A J, Soundararajan, Venky

“…mRNA coronavirus disease 2019 (COVID-19) vaccines are safe and effective, but increasing reports of breakthrough infections highlight the need to vigilantly…”
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Third dose vaccination with mRNA-1273 or BNT162b2 vaccines improves protection against SARS-CoV-2 infection by Niesen, Michiel J M, Matson, Robert, Puranik, Arjun, O'Horo, John C, Pawlowski, Colin, Vachon, Celine, Challener, Douglas, Virk, Abinash, Swift, Melanie, Speicher, Leigh, Gordon, Joel, Geyer, Holly, Lenehan, Patrick J, Venkatakrishnan, A J, Soundararajan, Venky, Badley, Andrew

“…As of 2021 November 29, booster vaccination against SARS-CoV-2 infection has been recommended for all individuals aged 18 years and older in the United States…”
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Case-control study on post-COVID-19 conditions reveals severe acute infection and chronic pulmonary disease as potential risk factors by Ghosh, Pritha, Niesen, Michiel J.M., Pawlowski, Colin, Bandi, Hari, Yoo, Unice, Lenehan, Patrick J., Kumar-M, Praveen, Nadig, Mihika, Ross, Jason, Ardhanari, Sankar, O’Horo, John C., Venkatakrishnan, A.J., Rosen, Clifford J., Telenti, Amalio, Hurt, Ryan T., Soundararajan, Venky

“…Post-COVID-19 conditions (long COVID) has impacted many individuals, yet risk factors for this condition are poorly understood. This retrospective analysis of…”
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Durability analysis of the highly effective BNT162b2 vaccine against COVID-19 by Puranik, Arjun, Lenehan, Patrick J, O'Horo, John C, Pawlowski, Colin, Niesen, Michiel J M, Virk, Abinash, Swift, Melanie D, Kremers, Walter, Venkatakrishnan, A J, Gordon, Joel E, Geyer, Holly L, Speicher, Leigh Lewis, Soundararajan, Venky, Badley, Andrew D

“…COVID-19 vaccines are effective, but breakthrough infections have been increasingly reported. We conducted a test-negative case-control study to assess the…”
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Continuous genomic diversification of long polynucleotide fragments drives the emergence of new SARS-CoV-2 variants of concern by Murugadoss, Karthik, Niesen, Michiel J M, Raghunathan, Bharathwaj, Lenehan, Patrick J, Ghosh, Pritha, Feener, Tyler, Anand, Praveen, Simsek, Safak, Suratekar, Rohit, Hughes, Travis K, Soundararajan, Venky

“…Highly transmissible or immuno-evasive SARS-CoV-2 variants have intermittently emerged, resulting in repeated COVID-19 surges. With over 6 million SARS-CoV-2…”
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Quantifying the immunological distinctiveness of emerging SARS-CoV-2 variants in the context of prior regional herd exposure by Niesen, Michiel J M, Murugadoss, Karthik, Lenehan, Patrick J, Marchler-Bauer, Aron, Wang, Jiyao, Connor, Ryan, Brister, J Rodney, Venkatakrishnan, A J, Soundararajan, Venky

“…The COVID-19 pandemic has seen the persistent emergence of immune-evasive SARS-CoV-2 variants under the selection pressure of natural and vaccination-acquired…”
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Coarse-Grained Modeling of Minute-Timescale Co-Translational Membrane Protein Integration via the Sec-Translocon by Niesen, Michiel J.M., Miller, Thomas F.

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Forces on Nascent Polypeptides during Membrane Insertion and Translocation via the Sec Translocon by Niesen, Michiel J.M., Müller-Lucks, Annika, Hedman, Rickard, von Heijne, Gunnar, Miller, Thomas F.

“…During ribosomal translation, nascent polypeptide chains (NCs) undergo a variety of physical processes that determine their fate in the cell. This study…”
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Coarse-Grained Modeling of Membrane Protein Integration via the Sec Translocon by Niesen, Michiel J.M., Wang, Connie Y., Miller, Thomas F.

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High diversity in Delta variant across countries revealed by genome‐wide analysis of SARS‐CoV‐2 beyond the Spike protein by Suratekar, Rohit, Ghosh, Pritha, Niesen, Michiel J M, Donadio, Gregory, Anand, Praveen, Soundararajan, Venky, Venkatakrishnan, A J

“…The highly contagious Delta variant of SARS‐CoV‐2 has become a prevalent strain globally and poses a public health challenge around the world. While there has…”
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Dynamics of Co-translational Membrane Protein Integration and Translocation via the Sec Translocon by Niesen, Michiel J. M, Zimmer, Matthew H

“…An important aspect of cellular function is the correct targeting and delivery of newly synthesized proteins. Central to this task is the machinery of the Sec…”
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The Role of Conformational Ensembles in Ligand Recognition in G-Protein Coupled Receptors by Niesen, Michiel J. M, Bhattacharya, Supriyo, Vaidehi, Nagarajan

“…G-protein coupled receptors (GPCRs) are allosteric membrane proteins mediating cellular signaling. GPCRs exhibit multiple inactive and active conformations,…”
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Improving membrane protein expression by optimizing integration efficiency by Niesen, Michiel J.M., Marshall, Stephen S., Miller, Thomas F., Clemons, William M.

“…The heterologous overexpression of integral membrane proteins in Escherichia coli often yields insufficient quantities of purifiable protein for applications…”
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Conformational Selection and Allosteric Regulation upon Ligand Binding in G-Protein Coupled Receptors by Niesen, Michiel J.M., Bhattacharya, Supriyo, Vaidehi, Nagarajan

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Structurally detailed coarse-grained model for Sec-facilitated co-translational protein translocation and membrane integration by Niesen, Michiel J M, Wang, Connie Y, Van Lehn, Reid C, Miller, 3rd, Thomas F

“…We present a coarse-grained simulation model that is capable of simulating the minute-timescale dynamics of protein translocation and membrane integration via…”
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On the Origins of Omicron's Unique Spike Gene Insertion by Venkatakrishnan, A J, Anand, Praveen, Lenehan, Patrick J, Suratekar, Rohit, Raghunathan, Bharathwaj, Niesen, Michiel J M, Soundararajan, Venky

“…The emergence of a heavily mutated SARS-CoV-2 variant (Omicron; Pango lineage B.1.1.529 and BA sublineages) and its rapid spread to over 75 countries raised a…”
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Surveillance of Safety of 3 Doses of COVID-19 mRNA Vaccination Using Electronic Health Records by Niesen, Michiel J M, Pawlowski, Colin, O'Horo, John C, Challener, Doug W, Silvert, Eli, Donadio, Greg, Lenehan, Patrick J, Virk, Abinash, Swift, Melanie D, Speicher, Leigh L, Gordon, Joel E, Geyer, Holly L, Halamka, John D, Venkatakrishnan, A J, Soundararajan, Venky, Badley, Andrew D

“…Recent reports on waning of COVID-19 vaccine-induced immunity have led to the approval and rollout of additional doses and booster vaccinations. Individuals at…”
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