Search Results - "Niese, Kathryn A."

TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis by Scheraga, Rachel G, Abraham, Susamma, Niese, Kathryn A, Southern, Brian D, Grove, Lisa M, Hite, R Duncan, McDonald, Christine, Hamilton, Thomas A, Olman, Mitchell A

“…Macrophage phagocytosis of particles and pathogens is an essential aspect of innate host defense. Phagocytic function requires cytoskeletal rearrangements that…”
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Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner by Kottyan, Leah C., Collier, Ann R., Cao, Khanh H., Niese, Kathryn A., Hedgebeth, Megan, Radu, Caius G., Witte, Owen N., Khurana Hershey, Gurjit K., Rothenberg, Marc E., Zimmermann, Nives

“…The microenvironment of the lung in asthma is acidic, yet the effect of acidity on inflammatory cells has not been well established. We now demonstrate that…”
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The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis by Niese, Kathryn A, Chiaramonte, Monica G, Ellies, Lesley G, Rothenberg, Marc E, Zimmermann, Nives

“…Arginine is an amino acid that serves as a substrate for the enzymes nitric oxide synthase (NOS) and arginase, leading to synthesis of NO and ornithine,…”
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TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice by Rahaman, Shaik O, Grove, Lisa M, Paruchuri, Sailaja, Southern, Brian D, Abraham, Susamma, Niese, Kathryn A, Scheraga, Rachel G, Ghosh, Sudakshina, Thodeti, Charles K, Zhang, David X, Moran, Magdalene M, Schilling, William P, Tschumperlin, Daniel J, Olman, Mitchell A

“…Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disorder with no effective medical treatments available. The generation of myofibroblasts, which…”
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Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype by Southern, Brian D., Grove, Lisa M., Rahaman, Shaik O., Abraham, Susamma, Scheraga, Rachel G., Niese, Kathryn A., Sun, Huanxing, Herzog, Erica L., Liu, Fei, Tschumperlin, Daniel J., Egelhoff, Thomas T., Rosenfeld, Steven S., Olman, Mitchell A.

“…Pro-fibrotic mesenchymal cells are known to be the key effector cells of fibroproliferative disease, but the specific matrix signals and the induced cellular…”
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Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice by Niese, Kathryn A, Collier, Ann R, Hajek, Amanda R, Cederbaum, Stephen D, O'Brien, William E, Wills-Karp, Marsha, Rothenberg, Marc E, Zimmermann, Nives

“…Arginase is significantly upregulated in the lungs in murine models of asthma, as well as in human asthma, but its role in allergic airway inflammation has not…”
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Role of Cation Channel TRPV4 in Mechanosensing, Myofibroblast Differentiation, and Pulmonary Fibrosis by Rahaman, Shaik O., Grove, Lisa M., Southern, Brian D., Scheraga, Rachel G., Abraham, Susamma, Niese, Kathryn A., Ghosh, Sudakshina, Tschumperlin, Daniel J., Olman, Mitchell A.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disorder with marginally effective medical treatment. Myofibroblasts are critical to the…”
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TRPV4 Mechanosensitive Ion Channel Regulates LPS-Stimulated Macrophage Phagocytosis by Scheraga, Rachel G., Abraham, Susamma, Niese, Kathryn A., Southern, Brian D., Grove, Lisa M., Hite, R. Duncan, McDonald, Christine, Hamilton, Thomas A., Olman, Mitchell A.

“…Macrophage phagocytosis of particles and pathogens is an essential aspect of innate host defense. Phagocytic function requires cytoskeletal rearrangements that…”
Get full text