Search Results - "Nies, Vera J M"
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Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease
Published in Proceedings of the National Academy of Sciences - PNAS (23-02-2016)“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder and is strongly associated with obesity and type 2 diabetes. Currently,…”
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Regulatory considerations for developing remote measurement technologies for Alzheimer’s disease research
Published in NPJ digital medicine (04-09-2024)“…The Remote Assessment of Disease and Relapse – Alzheimer’s Disease (RADAR-AD) consortium evaluated remote measurement technologies (RMTs) for assessing…”
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Fibroblast Growth Factor Signaling in Metabolic Regulation
Published in Frontiers in endocrinology (Lausanne) (19-01-2016)“…The prevalence of obesity is a growing health problem. Obesity is strongly associated with several comorbidities, such as non-alcoholic fatty liver disease,…”
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Digital endpoints in clinical trials of Alzheimer's disease and other neurodegenerative diseases: challenges and opportunities
Published in Frontiers in neurology (2023)“…Alzheimer's disease (AD) and other neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's disease (HD) are associated with progressive…”
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Autocrine FGF1 signaling promotes glucose uptake in adipocytes
Published in Proceedings of the National Academy of Sciences - PNAS (04-10-2022)“…Fibroblast growth factor 1 (FGF1) is an autocrine growth factor released from adipose tissue during over-nutrition or fasting to feeding transition. While…”
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Remote monitoring technologies in Alzheimer's disease: design of the RADAR-AD study
Published in Alzheimer's research & therapy (23-04-2021)“…Functional decline in Alzheimer's disease (AD) is typically measured using single-time point subjective rating scales, which rely on direct observation or…”
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Hyperglycemia Induces Bioenergetic Changes in Adipose-Derived Stromal Cells While Their Pericytic Function Is Retained
Published in Stem cells and development (01-10-2016)“…Diabetic retinopathy (DR) is a hyperglycemia (HG)-mediated microvascular complication. In DR, the loss of pericytes and subsequently endothelial cells leads to…”
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IMI European Lead Factory — democratizing access to high-throughput screening
Published in Nature reviews. Drug discovery (01-04-2022)“…The European Lead Factory combines assets and experience from major pharma with innovation and agility of academia and SMEs in a collaborative platform to…”
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