Search Results - "Niers, Johanna M"

Human Glioma Growth Is Controlled by MicroRNA-10b by GABRIELY, Galina, MING YI, TANNOUS, Bakhos A, KRICHEVSKY, Anna M, NARAYAN, Ravi S, NIERS, Johanna M, WURDINGER, Thomas, IMITOLA, Jaime, LIGON, Keith L, KESARI, Santosh, ESAU, Christine, STEPHENS, Robert M

“…MicroRNA (miRNA) expression profiling studies revealed a number of miRNAs dysregulated in the malignant brain tumor glioblastoma. Molecular functions of these…”
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Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2 by Smits, Michiel, Mir, Shahryar E, Nilsson, R Jonas A, van der Stoop, Petra M, Niers, Johanna M, Marquez, Victor E, Cloos, Jacqueline, Breakefield, Xandra O, Krichevsky, Anna M, Noske, David P, Tannous, Bakhos A, Würdinger, Thomas

“…Angiogenesis is a balanced process controlled by pro- and anti-angiogenic molecules of which the regulation is not fully understood. Besides classical gene…”
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miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis by Smits, Michiel, Nilsson, Jonas, Mir, Shahryar E, van der Stoop, Petra M, Hulleman, Esther, Niers, Johanna M, de Witt Hamer, Phillip C, Marquez, Victor E, Cloos, Jacqueline, Krichevsky, Anna M, Noske, David P, Tannous, Bakhos A, Würdinger, Thomas

“…Glioblastoma (GBM) is a malignant brain tumor with dismal prognosis. GBM patients have a median survival of less than 2 years. GBM is characterized by fast…”
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Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs by TANNOUS, Bakhos A, KERAMI, Mariam, LAGERWEIJ, Tonny, WEDEKIND, Laurine, NIERS, Johanna M, BARAZAS, Marco, NILSSON, R. Jonas A, GEERTS, Dirk, DE WITT HAMER, Philip C, HAGEMANN, Carsten, VANDERTOP, W. Peter, VAN TELLINGEN, Olaf, VAN DER STOOP, Petra M, NOSKE, David P, GRAY, Nathanael S, WÜRDINGER, Thomas, KWIATKOWSKI, Nicholas, JINHUA WANG, WENJUN ZHOU, KESSLER, Almuth F, LEWANDROWSKI, Grant, HIDDINGH, Lotte, SOL, Nik

“…Glioblastomas exhibit a high level of chemotherapeutic resistance, including to the antimitotic agents vincristine and taxol. During the mitotic agent-induced…”
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Gaussia Luciferase Variant for High-Throughput Functional Screening Applications by Maguire, Casey A, Deliolanis, Nikolaos C, Pike, Lisa, Niers, Johanna M, Tjon-Kon-Fat, Lee-Ann, Sena-Esteves, Miguel, Tannous, Bakhos A

“…Gaussia luciferase (Gluc) is a sensitive reporter for studying different biological processes such as gene expression, promoter activity, protein−protein…”
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Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway by Badr, Christian E., Wurdinger, Thomas, Nilsson, Jonas, Niers, Johanna M., Whalen, Michael, Degterev, Alexei, Tannous, Bakhos A.

“…Human glioblastoma (GBM) cells are notorious for their resistance to apoptosis-inducing therapeutics. We have identified lanatoside C as a sensitizer of GBM…”
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Triple Bioluminescence Imaging for In Vivo Monitoring of Cellular Processes by Maguire, Casey A, Bovenberg, M Sarah, Crommentuijn, Matheus HW, Niers, Johanna M, Kerami, Mariam, Teng, Jian, Sena-Esteves, Miguel, Badr, Christian E, Tannous, Bakhos A

“…Bioluminescence imaging (BLI) has shown to be crucial for monitoring in vivo biological processes. So far, only dual bioluminescence imaging using firefly…”
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In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma by Mir, Shahryar E., De Witt Hamer, Philip C., Krawczyk, Przemek M., Balaj, Leonora, Claes, An, Niers, Johanna M., Van Tilborg, Angela A.G., Zwinderman, Aeilko H., Geerts, Dirk, Kaspers, Gertjan J.L., Peter Vandertop, W., Cloos, Jacqueline, Tannous, Bakhos A., Wesseling, Pieter, Aten, Jacob A., Noske, David P., Van Noorden, Cornelis J.F., Würdinger, Thomas

“…Kinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment. Here we analyze the kinase gene…”
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Baseline factors relating to depressive symptoms at one year postoperative in patients with diffuse glioma by Belgers, Vera, Tolver, Anders, Klein, Martin, Douw, Linda, Niers, Johanna M, Piil, Karin, de Witt Hamer, Philip C

“…Abstract Background Depressive symptoms are common in patients with diffuse glioma, potentially reducing their quality of life. Understanding baseline factors…”
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Multimodal In Vivo Imaging and Blood Monitoring of Intrinsic and Extrinsic Apoptosis by Niers, Johanna M, Kerami, Mariam, Pike, Lisa, Lewandrowski, Grant, Tannous, Bakhos A

“…Noninvasive detection and in vivo imaging of apoptosis plays a critical role in the development of therapeutics in many different fields including cancer. We…”
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Single Reporter for Targeted Multimodal in Vivo Imaging by Niers, Johanna M, Chen, John W, Lewandrowski, Grant, Kerami, Mariam, Garanger, Elisabeth, Wojtkiewicz, Greg, Waterman, Peter, Keliher, Edmund, Weissleder, Ralph, Tannous, Bakhos A

“…We have developed a multifaceted, highly specific reporter for multimodal in vivo imaging and applied it for detection of brain tumors. A metabolically…”
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Tumor location is associated with mood dysfunction in patients with diffuse glioma by van Genderen, Maisa N. G., Belgers, Vera, Niers, Johanna M., Douw, Linda, Röttgering, Jantine G., Gorter, Maxine, Blom, Marieke E. C., Barkhof, Frederik, Klein, Martin, Eijgelaar, Roelant S., De Witt Hamer, Philip C.

“…Abstract Gliomas are primary brain tumors that can cause neuropsychiatric symptoms, including severe depressive symptoms (SDS; in 14%) and an absence of…”
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Enhanced in Vivo Imaging of Metabolically Biotinylated Cell Surface Reporters by Niers, Johanna M, Chen, John W, Weissleder, Ralph, Tannous, Bakhos A

“…Metabolic biotinylation of intracellular and secreted proteins as well as surface receptors in mammalian cells provides a versatile way to monitor gene…”
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Cannabinoids to Improve Health-Related Quality of Life in Patients with Neurological or Oncological Disease: A Meta-Analysis by Belgers, Vera, Röttgering, Jantine G, Douw, Linda, Klein, Martin, Ket, Johannes C F, van de Ven, Peter M, Würdinger, Thomas, van Linde, Myra E, Niers, Johanna M, Weber, Markus, Olde Rikkert, Marcel G, Lopez-Sendon, Jose, Arrieta, Oscar, Svendsen, Kristina B, Chagas, Marcos H N, de Almeida, Carlos M O, Kouwenhoven, Mathilde C M, de Witt Hamer, Philip C

“…Cannabinoids have been suggested to alleviate frequently experienced symptoms of reduced mental well-being such as anxiety and depression. Mental well-being is…”
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Longitudinal characteristics of T2-FLAIR mismatch in IDH-mutant astrocytomas: Relation to grade, histopathology, and overall survival in the GLASS-NL cohort by van Garderen, Karin A, Vallentgoed, Wies R, Lavrova, Anna, Niers, Johanna M, de Leng, Wendy W J, Hoogstrate, Youri, de Heer, Iris, Ylstra, Bauke, van Dijk, Erik, Klein, Stefan, Draaisma, Kaspar, Robe, Pierre A J T, Verhaak, Roel G W, Westerman, Bart A, French, Pim J, van den Bent, Martin J, Kouwenhoven, Mathilde C M, Kros, Johan M, Wesseling, Pieter, Smits, Marion

“…Abstract Background The T2-FLAIR mismatch sign is defined by signal loss of the T2-weighted hyperintense area with Fluid-Attenuated Inversion Recovery (FLAIR)…”
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Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma by Crommentuijn, Matheus H.W., Maguire, Casey A., Niers, Johanna M., Vandertop, W. Peter, Badr, Christian E., Würdinger, Thomas, Tannous, Bakhos A.

“…Glioblastoma (GBM) is the most common malignant brain tumor in adults. We designed an adeno-associated virus (AAV) vector for intracranial delivery of…”
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Real-Time Monitoring of Nuclear Factor κB Activity in Cultured Cells and in Animal Models by Badr, Christian E., Niers, Johanna M., Tjon-Kon-Fat, Lee-Ann, Noske, David P., Wurdinger, Thomas, Tannous, Bakhos A.

“…Nuclear factor κB (NF-κB) is a transcription factor that plays a major role in many human disorders, including immune diseases and cancer. We designed a…”
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Gaussia Luciferase Variant for High-Throughput Functional Screening Applications by Maguire, Casey A, Deliolanis, Nikolaos C, Pike, Lisa, Niers, Johanna M, Tjon-Kon-Fat, Lee-Ann, Sena-Esteves, Miguel, Tannous, Bakhos A

“…Gaussia luciferase (Gluc) is a sensitive reporter for studying different biological processes such as gene expression, promoter activity, protein-protein…”
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Real-time monitoring of NF-kappaB activity in cultured cells and in animal models by Badr, Christian, Niers, Johanna M., Tjon-Kon-Fat, Lee-Ann, Noske, David P., Wurdinger, Thomas, Tannous, Bakhos A.

“…Nuclear factor kappa B (NFkB) is a transcription factor that plays a major role in many human disorders, including immune diseases and cancer. Monitoring of…”
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Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal models by Badr, Christian E, Niers, Johanna M, Tjon-Kon-Fat, Lee-Ann, Noske, David P, Wurdinger, Thomas, Tannous, Bakhos A

“…Nuclear factor kappaB (NF-kappaB) is a transcription factor that plays a major role in many human disorders, including immune diseases and cancer. We designed…”
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