Search Results - "Nierman, William C"

SMURF: Genomic mapping of fungal secondary metabolite clusters by Khaldi, Nora, Seifuddin, Fayaz T., Turner, Geoff, Haft, Daniel, Nierman, William C., Wolfe, Kenneth H., Fedorova, Natalie D.

“…Fungi produce an impressive array of secondary metabolites (SMs) including mycotoxins, antibiotics and pharmaceuticals. The genes responsible for their…”
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The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis by Bertuzzi, Margherita, Schrettl, Markus, Alcazar-Fuoli, Laura, Cairns, Timothy C, Muñoz, Alberto, Walker, Louise A, Herbst, Susanne, Safari, Maryam, Cheverton, Angela M, Chen, Dan, Liu, Hong, Saijo, Shinobu, Fedorova, Natalie D, Armstrong-James, Darius, Munro, Carol A, Read, Nick D, Filler, Scott G, Espeso, Eduardo A, Nierman, William C, Haas, Hubertus, Bignell, Elaine M

“…Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely…”
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Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach by Espinoza, Josh L, Dupont, Chris L, O'Rourke, Aubrie, Beyhan, Sinem, Morales, Pavel, Spoering, Amy, Meyer, Kirsten J, Chan, Agnes P, Choi, Yongwook, Nierman, William C, Lewis, Kim, Nelson, Karen E

“…To better combat the expansion of antibiotic resistance in pathogens, new compounds, particularly those with novel mechanisms-of-action [MOA], represent a…”
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Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system by Gravelat, Fabrice N, Beauvais, Anne, Liu, Hong, Lee, Mark J, Snarr, Brendan D, Chen, Dan, Xu, Wenjie, Kravtsov, Ilia, Hoareau, Christopher M Q, Vanier, Ghyslaine, Urb, Mirjam, Campoli, Paolo, Al Abdallah, Qusai, Lehoux, Melanie, Chabot, Josée C, Ouimet, Marie-Claude, Baptista, Stefanie D, Fritz, Jörg H, Nierman, William C, Latgé, Jean Paul, Mitchell, Aaron P, Filler, Scott G, Fontaine, Thierry, Sheppard, Donald C

“…Aspergillus fumigatus is the most common cause of invasive mold disease in humans. The mechanisms underlying the adherence of this mold to host cells and…”
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Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station by O'Rourke, Aubrie, Lee, Michael D, Nierman, William C, Everroad, R Craig, Dupont, Chris L

“…The opportunistic pathogens Burkholderia cepacia and Burkholderia contaminans, both genomovars of the Burkholderia cepacia complex (BCC), are frequently…”
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Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability by Joardar, Vinita, Abrams, Natalie F, Hostetler, Jessica, Paukstelis, Paul J, Pakala, Suchitra, Pakala, Suman B, Zafar, Nikhat, Abolude, Olukemi O, Payne, Gary, Andrianopoulos, Alex, Denning, David W, Nierman, William C

“…The genera Aspergillus and Penicillium include some of the most beneficial as well as the most harmful fungal species such as the penicillin-producer…”
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SreA-mediated iron regulation in Aspergillus fumigatus by Schrettl, Markus, Kim, H. Stanley, Eisendle, Martin, Kragl, Claudia, Nierman, William C, Heinekamp, Thorsten, Werner, Ernst R, Jacobsen, Ilse, Illmer, Paul, Yi, Hyojeong, Brakhage, Axel A, Haas, Hubertus

“…Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two high-affinity iron uptake systems: iron uptake mediated by the…”
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Type VI secretion is a major virulence determinant in Burkholderia mallei by Schell, Mark A, Ulrich, Ricky L, Ribot, Wilson J, Brueggemann, Ernst E, Hines, Harry B, Chen, Dan, Lipscomb, Lyla, Kim, H. Stanley, Mrázek, Jan, Nierman, William C, DeShazer, David

“…Burkholderia mallei is a host-adapted pathogen and a category B biothreat agent. Although the B. mallei VirAG two-component regulatory system is required for…”
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Tight control of mycotoxin biosynthesis gene expression in Aspergillus flavus by temperature as revealed by RNA-Seq by Yu, Jiujiang, Fedorova, Natalie D., Montalbano, Beverly G., Bhatnagar, Deepak, Cleveland, Thomas E., Bennett, Joan W., Nierman, William C.

“…Abstract To better understand the effect of temperature on mycotoxin biosynthesis, RNA-Seq technology was used to profile the Aspergillus flavus transcriptome…”
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Whole genome comparison of Aspergillus flavus L-morphotype strain NRRL 3357 (type) and S-morphotype strain AF70 by Gilbert, Matthew K, Mack, Brian M, Moore, Geromy G, Downey, Darlene L, Lebar, Matthew D, Joardar, Vinita, Losada, Liliana, Yu, JiuJiang, Nierman, William C, Bhatnagar, Deepak

“…Aspergillus flavus is a saprophytic fungus that infects corn, peanuts, tree nuts and other agriculturally important crops. Once the crop is infected the fungus…”
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Transcript amplification from single bacterium for transcriptome analysis by Kang, Yun, Norris, Michael H, Zarzycki-Siek, Jan, Nierman, William C, Donachie, Stuart P, Hoang, Tung T

“…Total transcript amplification (TTA) from single eukaryotic cells for transcriptome analysis is established, but TTA from a single prokaryotic cell presents…”
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Longitudinal changes in the nasopharyngeal resistome of South African infants using shotgun metagenomic sequencing by Manenzhe, Rendani I, Dube, Felix S, Wright, Meredith, Lennard, Katie, Zar, Heather J, Mounaud, Stephanie, Nierman, William C, Nicol, Mark P, Moodley, Clinton

“…Nasopharyngeal (NP) colonization with antimicrobial-resistant bacteria is a global public health concern. Antimicrobial-resistance (AMR) genes carried by the…”
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Sub-telomere directed gene expression during initiation of invasive aspergillosis by McDonagh, Andrew, Fedorova, Natalie D, Crabtree, Jonathan, Yu, Yan, Kim, Stanley, Chen, Dan, Loss, Omar, Cairns, Timothy, Goldman, Gustavo, Armstrong-James, Darius, Haynes, Ken, Haas, Hubertus, Schrettl, Markus, May, Gregory, Nierman, William C, Bignell, Elaine

“…Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora. Immune dysfunction permits developmental growth of inhaled…”
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Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus by Fedorova, Natalie D, Khaldi, Nora, Joardar, Vinita S, Maiti, Rama, Amedeo, Paolo, Anderson, Michael J, Crabtree, Jonathan, Silva, Joana C, Badger, Jonathan H, Albarraq, Ahmed, Angiuoli, Sam, Bussey, Howard, Bowyer, Paul, Cotty, Peter J, Dyer, Paul S, Egan, Amy, Galens, Kevin, Fraser-Liggett, Claire M, Haas, Brian J, Inman, Jason M, Kent, Richard, Lemieux, Sebastien, Malavazi, Iran, Orvis, Joshua, Roemer, Terry, Ronning, Catherine M, Sundaram, Jaideep P, Sutton, Granger, Turner, Geoff, Venter, J Craig, White, Owen R, Whitty, Brett R, Youngman, Phil, Wolfe, Kenneth H, Goldman, Gustavo H, Wortman, Jennifer R, Jiang, Bo, Denning, David W, Nierman, William C

“…We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely…”
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Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA by Perrin, Robyn M, Fedorova, Natalie D, Bok, Jin Woo, Cramer, Robert A, Wortman, Jennifer R, Kim, H Stanley, Nierman, William C, Keller, Nancy P

“…Secondary metabolites, including toxins and melanins, have been implicated as virulence attributes in invasive aspergillosis. Although not definitively proved,…”
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Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in Virulence by Losada, Liliana, Sugui, Janyce A, Eckhaus, Michael A, Chang, Yun C, Mounaud, Stephanie, Figat, Abigail, Joardar, Vinita, Pakala, Suman B, Pakala, Suchitra, Venepally, Pratap, Fedorova, Natalie, Nierman, William C, Kwon-Chung, Kyung J

“…Invasive aspergillosis (IA) due to Aspergillus fumigatus is a major cause of mortality in immunocompromised patients. The discovery of highly fertile strains…”
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Succession and determinants of the early life nasopharyngeal microbiota in a South African birth cohort by Claassen-Weitz, Shantelle, Gardner-Lubbe, Sugnet, Xia, Yao, Mwaikono, Kilaza S, Mounaud, Stephanie Harris, Nierman, William C, Workman, Lesley, Zar, Heather J, Nicol, Mark P

“…Bacteria colonizing the nasopharynx play a key role as gatekeepers of respiratory health. Yet, dynamics of early life nasopharyngeal (NP) bacterial profiles…”
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Transcriptional Profiling Identifies a Role for BrlA in the Response to Nitrogen Depletion and for StuA in the Regulation of Secondary Metabolite Clusters in Aspergillus fumigatus by Twumasi-Boateng, Kwame, Yu, Yan, Chen, Dan, Gravelat, Fabrice N, Nierman, William C, Sheppard, Donald C

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The early stage of bacterial genome-reductive evolution in the host by Song, Han, Hwang, Junghyun, Yi, Hyojeong, Ulrich, Ricky L, Yu, Yan, Nierman, William C, Kim, Heenam Stanley

“…The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from…”
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HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus by Feng, Xizhi, Krishnan, Karthik, Richie, Daryl L, Aimanianda, Vishukumar, Hartl, Lukas, Grahl, Nora, Powers-Fletcher, Margaret V, Zhang, Minlu, Fuller, Kevin K, Nierman, William C, Lu, Long Jason, Latgé, Jean-Paul, Woollett, Laura, Newman, Simon L, Cramer, Jr, Robert A, Rhodes, Judith C, Askew, David S

“…Endoplasmic reticulum (ER) stress is a condition in which the protein folding capacity of the ER becomes overwhelmed by an increased demand for secretion or by…”
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