Search Results - "Niere, Marc"

The phosphate makes a difference: cellular functions of NADP by Agledal, Line, Niere, Marc, Ziegler, Mathias

“…Recent research has unraveled a number of unexpected functions of the pyridine nucleotides. In this review, we will highlight the variety of known…”
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Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells by Kulikova, Veronika, Shabalin, Konstantin, Nerinovski, Kirill, Dölle, Christian, Niere, Marc, Yakimov, Alexander, Redpath, Philip, Khodorkovskiy, Mikhail, Migaud, Marie E., Ziegler, Mathias, Nikiforov, Andrey

“…NAD is essential for cellular metabolism and has a key role in various signaling pathways in human cells. To ensure proper control of vital reactions, NAD must…”
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Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells by VanLinden, Magali R., Dölle, Christian, Pettersen, Ina K.N., Kulikova, Veronika A., Niere, Marc, Agrimi, Gennaro, Dyrstad, Sissel E., Palmieri, Ferdinando, Nikiforov, Andrey A., Tronstad, Karl Johan, Ziegler, Mathias

“…The mitochondrial NAD pool is particularly important for the maintenance of vital cellular functions. Although at least in some fungi and plants, mitochondrial…”
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An Organellar Nα-Acetyltransferase, Naa60, Acetylates Cytosolic N Termini of Transmembrane Proteins and Maintains Golgi Integrity by Aksnes, Henriette, Van Damme, Petra, Goris, Marianne, Starheim, Kristian K., Marie, Michaël, Støve, Svein Isungset, Hoel, Camilla, Kalvik, Thomas Vikestad, Hole, Kristine, Glomnes, Nina, Furnes, Clemens, Ljostveit, Sonja, Ziegler, Mathias, Niere, Marc, Gevaert, Kris, Arnesen, Thomas

“…N-terminal acetylation is a major and vital protein modification catalyzed by N-terminal acetyltransferases (NATs). NatF, or Nα-acetyltransferase 60 (Naa60),…”
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Functional Localization of Two Poly(ADP-Ribose)-Degrading Enzymes to the Mitochondrial Matrix by Niere, Marc, Kernstock, Stefan, Koch-Nolte, Friedrich, Ziegler, Mathias

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms by Love, Nick R., Pollak, Nadine, Dölle, Christian, Niere, Marc, Chen, Yaoyao, Oliveri, Paola, Amaya, Enrique, Patel, Sandip, Ziegler, Mathias

“…Nicotinamide adenine dinucleotide phosphate (NADP) is a critical cofactor during metabolism, calcium signaling, and oxidative defense, yet how animals regulate…”
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NAD Kinase Levels Control the NADPH Concentration in Human Cells by Pollak, Nadine, Niere, Marc, Ziegler, Mathias

“…NAD kinases (NADKs) are vital, as they generate the cellular NADP pool. As opposed to three compartment-specific isoforms in plants and yeast, only a single…”
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Isoform-specific Targeting and Interaction Domains in Human Nicotinamide Mononucleotide Adenylyltransferases by Lau, Corinna, Dölle, Christian, Gossmann, Toni I., Agledal, Line, Niere, Marc, Ziegler, Mathias

“…Several important signaling pathways require NAD as substrate, thereby leading to significant consumption of the molecule. Because NAD is also an essential…”
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Structural and Functional Characterization of Human NAD Kinase by Lerner, Felicitas, Niere, Marc, Ludwig, Antje, Ziegler, Mathias

“…NADP is essential for biosynthetic pathways, energy, and signal transduction. Its synthesis is catalyzed by NAD kinase. Very little is known about the…”
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Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells by Nikiforov, Andrey, Dölle, Christian, Niere, Marc, Ziegler, Mathias

“…NAD is a vital redox carrier, and its degradation is a key element of important regulatory pathways. NAD-mediated functions are compartmentalized and have to…”
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Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis by Schweiger, Manfred, Hennig, Klaus, Lerner, Felicitas, Niere, Marc, Hirsch-Kauffmann, Monica, Specht, Thomas, Weise, Christoph, Oei, Shiao Li, Ziegler, Mathias

“…Nicotinamide mononucleotide adenylyl transferase (NMNAT) is an essential enzyme in all organisms, because it catalyzes a key step of NAD synthesis. However,…”
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Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation by Nikiforov, Andrey, Dölle, Christian, Niere, Marc, Ziegler, Mathias

“…NAD is a vital redox carrier, and its degradation is a key element of important regulatory pathways. NAD-mediated functions are compartmentalized and have to…”
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A regulated switch of chick neurofascin isoforms modulates ligand recognition and neurite extension by Pruss, Thomas, Kranz, Eva Ursula, Niere, Marc, Volkmer, Hansjürgen

“…Neural cell adhesion molecule neurofascin regulates the induction of neurite outgrowth, the establishment of synaptic connectivity and myelination. Neurofascin…”
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Insect immune activation by recombinant Galleria mellonella apolipophorin III by Niere, Marc, Meißlitzer, Claudia, Dettloff, Matthias, Weise, Christoph, Ziegler, Mathias, Wiesner, Andreas

“…Apolipophorin III (apoLp-III) is an exchangeable insect apolipoprotein. Its function, as currently understood, lies in the stabilization of low-density…”
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SLC25A51 is a mammalian mitochondrial NAD+ transporter by Luongo, Timothy S., Eller, Jared M., Lu, Mu-Jie, Niere, Marc, Raith, Fabio, Perry, Caroline, Bornstein, Marc R., Oliphint, Paul, Wang, Lin, McReynolds, Melanie R., Migaud, Marie E., Rabinowitz, Joshua D., Johnson, F. Brad, Johnsson, Kai, Ziegler, Mathias, Cambronne, Xiaolu A., Baur, Joseph A.

“…Mitochondria require nicotinamide adenine dinucleotide (NAD + ) to carry out the fundamental processes that fuel respiration and mediate cellular energy…”
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Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity by Houry, Dorothée, Raasakka, Arne, Ferrario, Eugenio, Niere, Marc, Bifulco, Ersilia, Kursula, Petri, Ziegler, Mathias

“…[Display omitted] •NAMPT is vital in mammals to synthesize NAD from nicotinamide.•Phosphorylation of His247 mediates optimal alignment of substrates…”
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Identification of evolutionary and kinetic drivers of NAD-dependent signaling by Bockwoldt, Mathias, Houry, Dorothée, Niere, Marc, Gossmann, Toni I., Reinartz, Ines, Schug, Alexander, Ziegler, Mathias, Heiland, Ines

“…Nicotinamide adenine dinucleotide (NAD) provides an important link between metabolism and signal transduction and has emerged as central hub between…”
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ADP-ribosylhydrolase 3 (ARH3), Not Poly(ADP-ribose) Glycohydrolase (PARG) Isoforms, Is Responsible for Degradation of Mitochondrial Matrix-associated Poly(ADP-ribose) by Niere, Marc, Mashimo, Masato, Agledal, Line, Dölle, Christian, Kasamatsu, Atsushi, Kato, Jiro, Moss, Joel, Ziegler, Mathias

“…Important cellular processes are regulated by poly(ADP-ribosyl)ation. This protein modification is catalyzed mainly by nuclear poly(ADP-ribose) polymerase…”
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Visualization of subcellular NAD pools and intra-organellar protein localization by poly-ADP-ribose formation by Dölle, Christian, Niere, Marc, Lohndal, Emilia, Ziegler, Mathias

“…Poly-ADP-ribose polymerases (PARPs) use NAD + as substrate to generate polymers of ADP-ribose. We targeted the catalytic domain of human PARP1 as molecular NAD…”
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Dynamics of SLC25A51 reveal preference for oxidized NAD + and substrate led transport by Goyal, Shivansh, Paspureddi, Akhilesh, Lu, Mu-Jie, Chan, Hsin-Ru, Lyons, Scott N, Wilson, Crystal N, Niere, Marc, Ziegler, Mathias, Cambronne, Xiaolu A

“…SLC25A51 is a member of the mitochondrial carrier family (MCF) but lacks key residues that contribute to the mechanism of other nucleotide MCF transporters…”
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