Search Results - "Nieoullon, A."

Dopamine and the regulation of cognition and attention by Nieoullon, André

“…Dopamine (DA) acts as a key neurotransmitter in the brain. Numerous studies have shown its regulatory role for motor and limbic functions. However, in the…”
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Dopamine: a key regulator to adapt action, emotion, motivation and cognition by Nieoullon, André, Coquerel, Antoine

“…Dopamine is expressed in restricted brain areas involved in numerous integrative functions contributing to automated behaviours that are highly adaptive…”
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Differential regulation by protein kinases of activity and cell surface expression of glutamate transporters in neuron-enriched cultures by Guillet, B.A., Velly, L.J., Canolle, B., Masmejean, F.M., Nieoullon, A.L., Pisano, P.

“…This study described the involvement of short-term PKA, PKC or PI3K phosphorylation-mediated processes in the regulation of activity and trafficking of the…”
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The nucleus accumbens 5-HTR4-CART pathway ties anorexia to hyperactivity by Jean, A, Laurent, L, Bockaert, J, Charnay, Y, Dusticier, N, Nieoullon, A, Barrot, M, Neve, R, Compan, V

“…In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between…”
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Dopaminergic contribution to the regulation of emotional perception by Salgado-Pineda, Pilar, Delaveau, Pauline, Blin, Olivier, Nieoullon, André

“…Dopamine (DA) acts as a key neurotransmitter in the brain. Numerous studies have shown its regulatory role in motor and cognitive function. However, the…”
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Excitotoxic lesions of the prelimbic-infralimbic areas of the rodent prefrontal cortex disrupt motor preparatory processes by Risterucci, Céline, Terramorsi, Denise, Nieoullon, André, Amalric, Marianne

“…The medial prefrontal cortex (mPFC) is involved in a variety of cognitive and emotional processes; in rodents its implication in motor planning is less known,…”
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Plasma membrane expression of the neuronal glutamate transporter EAAC1 is regulated by glial factors: Evidence for different regulatory pathways associated with neuronal maturation by Lortet, S., Canolle, B., Masmejean, F., Nieoullon, A.

“…At the glutamatergic synapse the neurotransmitter is removed from the synaptic cleft by high affinity amino acid transporters located on neurons (EAAC1) and…”
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In a rat model of parkinsonism, lesions of the subthalamic nucleus reverse increases of reaction time but induce a dramatic premature responding deficit by Baunez, C, Nieoullon, A, Amalric, M

“…Lesions of the subthalamic nucleus (STN) have been found to reduce the severe akinetic motor symptom produced in animal models of Parkinson's disease, such as…”
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Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: Role of glutamate uptake and FK506 binding protein 12 kDa by Labrande, C., Velly, L., Canolle, B., Guillet, B., Masmejean, F., Nieoullon, A., Pisano, Pascale

“…Background: The mechanisms underlying the neuroprotective effects of the immunosuppressant tacrolimus, observed in vivo, remain unclear. Here we quantify these…”
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Glial soluble factors regulate the activity and expression of the neuronal glutamate transporter EAAC1: implication of cholesterol by Canolle, B., Masmejean, F., Melon, C., Nieoullon, A., Pisano, P., Lortet, S.

“…A co‐ordinated regulation between neurons and astrocytes is essential for the control of extracellular glutamate concentration. Here, we have investigated the…”
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The metabotropic glutamate receptor subtype 5 antagonist MPEP and the Na+ channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions by Risterucci, C., Coccurello, R., Banasr, M., Stutzmann, J.M., Amalric, M., Nieoullon, A.

“…Overactivation of excitatory amino acid receptors has been involved in several neurodegenerative diseases. The present study aims at investigating the…”
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ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain by Broccardo, Cyril, Nieoullon, Vincent, Amin, Rada, Masmejean, Frédérique, Carta, Sonia, Tassi, Sara, Pophillat, Matthieu, Rubartelli, Anna, Pierres, Michel, Rougon, Geneviève, Nieoullon, André, Chazal, Genèvieve, Chimini, Giovanna

“…The notion that the ATP‐binding cassette transporter‐A2 (ABCA2) may be involved in brain sterol homeostasis and is associated with early onset Alzheimer's…”
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Regional distribution and ontogeny of 5-HT4 binding sites in rodent brain by Waeber, C, Sebben, M, Nieoullon, A, Bockaert, J, Dumuis, A

“…We have investigated the regional distribution of 5-hydroxytryptamine4 (5-HT4) receptor binding sites in the adult guinea pig, rat and mouse brain using the…”
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Effects of dopamine D1 and D2 receptor blockade on MK-801-induced hyperlocomotion in rats by OUAGAZZAL, A, NIEOULLON, A, AMALRIC, M

“…Blocking glutamatergic transmission at the N-methyl-D-aspartate (NMDA) receptor complex with MK-801 (0.15-0.5 mg/kg, IP) was found to induce a robust,…”
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Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat by Amalric, M, Moukhles, H, Nieoullon, A, Daszuta, A

“…The present study examined the ability of rats subjected to bilateral 6-hydroxydopamine lesions of the terminal area of the nigrostriatal dopamine system to…”
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Developmental expression and activity of high affinity glutamate transporters in rat cortical primary cultures by Guillet, B, Lortet, S, Masmejean, F, Samuel, D, Nieoullon, A, Pisano, P

“…The expression and activity of glutamate transporters (EAAC1, GLAST and GLT1) were examined during the development of cortical neuron-enriched cultures…”
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Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: Role of glutamate and its transporters by VELLY, Lionel J, GUILLET, Benjamin A, MASMEJEAN, Frederique M, NIEOULLON, André L, BRUDER, Nicolas J, GOUIN, Francois M, PISANO, Pascale M

“…During cerebral ischemia, excess of glutamate release and dysfunction of its high affinity transport induce an accumulation of extracellular glutamate, which…”
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Nigrostriatal denervation does not affect glutamate transporter mRNA expression but subsequent levodopa treatment selectively increases GLT1 mRNA and protein expression in the rat striatum by Liévens, J.‐C., Salin, P., Nieoullon, A., Kerkerian‐Le Goff, L.

“…There is growing evidence that the loss of the nigrostriatal dopaminergic neurones induces an overactivity of the corticostriatal glutamatergic pathway which…”
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Dopamine and complex sensorimotor integration: Further studies in a conditioned motor task in the rat by Baunez, C., Nieoullon, A., Amalric, M.

“…Rats were trained to depress a lever and wait for the onset of a light stimulus, occurring after four equiprobable and variable intervals. At the stimulus…”
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Importance of astrocytic inactivation of synaptically released glutamate for cell survival in the central nervous system—are astrocytes vulnerable to low intracellular glutamate concentrations? by Had-Aissouni, Laurence, Ré, Diane-Bérangère, Nieoullon, André, Kerkerian-Le Goff, Lydia

“…Multiple levels of neuron-astrocyte interactions do exist at glutamatergic synapses, glial glutamate transporters being involved in most of them. Inactivation…”
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